Manchester and Tyne-Wear derbies, Rugby World Cup semi-finals, the US Grand Prix... and even some NFL at Wembley! Your guide to the ultimate weekend of sport

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Hong Kong Open continues with Justin Rose and Ian Poulter in contention
Manchester United host Manchester City in the Premier League
Sunderland take on rivals Newcastle United at the Stadium of Light
Lewis Hamilton aiming for third world title with US Grand Prix victory
Pakistan-England Test series continues in Dubai
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In the Rugby World Cup semi-finals, favourites New Zealand face South Africa on Saturday while Australia take on Argentina on Sunday

By Richard Amofa For Mailonline and Matt Morlidge for MailOnline

Published: 05:54 EST, 23 October 2015 | Updated: 10:51 EST, 23 October 2015

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Ahead of an epic weekend of sport, we bring you the ultimate guide to all the action.

There are derbies to look forward to in the Premier League as well as the small matter of two crunch Rugby World Cup semi-finals, while the Pakistan-England Test series continues and Lewis Hamilton aims for third Formula One world title. And there's more.

Read on for all the details, and remember to keep track of the latest news with Sportsmail.

Saturday, October 24

Hong Kong Open - Third round

Sky Sports 4, 6am

Fancy an early start? How about Justin Rose vs Ian Poulter? The two English hopefuls are sitting pretty at the top of the leaderboard in Hong Kong and we could have a tasty battle on our hands this weekend. Rose, leading on nine-under, admits he is wary of Ryder Cup team-mate Poulter, who also hit a 66 in the second round. Lucas Bjerregaard and Lu Wei-Chih are also in the mix.

Justin Rose is leading the way at the Hong Kong Open and will hope to secure a victory this weekend

Pakistan vs England - Day 3, second Test

Sky Sports 2, on air 6.30am

Morning session starts 7am

Another morning treat as England aim to turn up the heat in Dubai after the first Test ended in a draw. Alastair Cook is hoping to lead his side to another series win after the Ashes triumph, and his bowlers have impressed so far in this second Test despite the slow pitch.

The England bowlers toiled in the heat in Dubai but impressed in the first innings against Pakistan

Blackburn vs Burnley - Sky Bet Championship

Sky Sports 1, on air 12pm

Kick-off 12.30pm

Blackburn may be a bit chillier than Dubai at this time of year, but this is still a Lancashire hot pot. Burnley are fifth in the Championship and are hoping to bounce back up to the Premier League; they're making the 11-mile trip to Ewood Park on Saturday lunchtime. This 'Battle of the Burns' has a long history, and the hosts will be determined to put their own struggles behind them and deny their high-flying rivals. No early Premier League kick-off? No problem.

The East Lancashire derby returns to the Championship on Saturday, will we see a chicken on the pitch again?

South Africa v New Zealand – Rugby World Cup semi-final

ITV 1, on air 3pm

Kick-off 4pm

New Zealand take on South Africa in the first Rugby World Cup semi-final at Twickenham. The All Blacks were rampant in the last round, destroying France with the performance of the tournament, while South Africa scraped past Wales. The Springboks will be boosted by the fitness of influential lock, Lood de Jager, but they will they have their work cut out to stop this breathtaking New Zealand side.

New Zealand produced the performance of the Rugby World Cup so far to defeat France in the semi-final

Arsenal vs Everton – Barclays Premier League

Sky Sports 1, on air 5pm

Kick-off 5.30pm

The Gunners host Everton at the Emirates Stadium knowing that a win will take them to the top of the Premier League. Arsenal will be buoyed by recent victories against Manchester United and Bayern Munich ,and will be looking to maintain that momentum against an Everton side currently sitting in ninth. A good omen for the Londoners is that they have beaten the Toffees on more occasions than any team has beaten another in the history of English league football, winning 91 of their 189 previous meetings.

Arsenal will be on a high ahead of the visit of Everton after beating Bayern Munich 2-0 at the Emirates Stadium

United States Grand Prix - Practice 3 and Qualifying

Sky Sports F1

Practice 3 on air 3.45pm. Session starts 4pm

Qualifying on air 6pm. Session starts 7pm

Lewis Hamilton is closing in on a third world title and he can claim it with three races to spare in Austin. The Briton's chances of doing just that have improved, with closest rival Sebastian Vettel being handed a 10-place grid penalty, but can he qualify fastest ahead of Mercedes team-mate Nico Rosberg?

Lewis Hamilton can secure his third world title this weekend with a victory at the US Grand Prix

Chris Eubank Jnr vs Tony Jeter – WBA Interim Middleweight Championship

Sky Sports 1, 8pm

Interim WBA middleweight champion Chris Eubank Jnr takes on American Tony Jeter at the Sheffield Arena on Saturday. The Brit comes into the fight as favourite, but will have to be on top of his game to defeat the experienced American who has won three of his last four fights by knockout. Gavin McDonnell is also on the card as he defends his EBU super-bantamweight title against Jeremy Parodi.

Chris Eubank Jnr is defending his WBA Interim Middleweight Championship against Tony Jeter on Saturday

Sunday, October 25

Hong Kong Open - Fourth round

Sky Sports 4, 4am

Depending on how much you enjoy Saturday you may fancy getting up even earlier for the final round in Hong Kong. Poulter made a frantic dash to Hong Kong from Orlando - via New York - to start here and he will be determined to break back into the world's top 50.

Ian Poulter had to race over to Hong Kong from Orlando - via New York - but is in contention

Pakistan vs England - Day 4, second Test

Sky Sports 2, air time 6am

Morning session starts 7am

In the fourth day of the second Test against Pakistan, England will be looking to go one better here. But with Pakistan captain, Misbah-ul-Haq looking in great form, England’s bowlers will have to be at the top of their game if they are going to be victorious in Dubai.

Misbah-ul-Haq has been in fine form for Pakistan and England will hope to dismiss him early in the next innings

Sunderland vs Newcastle United – Barclays Premier League

Sky Sports 1, air time 11.30am

Kick-off 12pm

Sam Allardyce hosts his former club in his first Wear-Tyne derby as Sunderland manager. Sunday’s fixture also sees a derby debut for Steve McClaren who takes his Newcastle side to the Stadium of Light looking to prevent a sixth successive Sunderland win over the Magpies. Newcastle come into the game in good form having put six past Norwich last week, whilst the Mackems tasted defeat away at West Brom.

Jermain Defoe nets a screamer for Sunderland in the Tyne-Wear derby against Newcastle last season

Buffalo Bills @ Jacksonville Jaguars - NFL

Sky Sports 3, air time 12.30pm. BBC 2 air time 1pm

Kick-off 1.30pm

In another installment of English-based NFL action, the Buffalo Bills face the Jacksonville Jaguars at Wembley. Despite being injury hit, the Bills come into the game as huge favourites, and a win here will certainly kickstart their play-off push. On the other hand, the Jaguars will want to win to erase the memory of last season’s Wembley defeat by the Dallas Cowboys.

Buffalo Bills train ahead of their NFL match at Wembley against the Jacksonville Jaguars on Sunday

Manchester United v Manchester City – Barclays Premier League

Sky Sports 1, air time 2pm

Kick-off 2.05pm

The Red Devils take on their 'noisy neighbours' in the first Manchester derby of the season. Both clubs spent big in the summer in order to topple last season’s Champions, Chelsea, and have displayed decent form coming into the game. Of course, the title will not be decided on Sunday, but defeat for either side will be a bitter blow, especially against their local rivals. New signings Anthony Martial, in red, and Kevin De Bruyne, in blue, are both in top form.

Manchester United defender Chris Smalling celebrates scoring against Manchester City last season

Argentina v Australia – Rugby World Cup semi-final

ITV 1, air time 3pm

Kick-off 4pm

Can Argentina really reach their first World Cup final? They obliterated Ireland in the quarter-final and will be full of confidence going into this match at Twickenham with Australia. The Wallabies are lucky to be here, following their narrow victory against Scotland, but everyone (especially England fans) knows how much quality they possess on their day.

Australia were lucky to defeat Scotland in the Rugby World Cup quarter-finals after a late penalty

Juan Imhoff celebrates as he runs to the try line during Argentina's demolition of Ireland at Cardiff

Liverpool vs Southampton - Barclays Premier League

Sky Sports 1, air time 4pm

Kick-off 4.15pm

Jurgen Klopp manages his first league game at Anfield as his Liverpool side host Southampton. The German’s Anfield bow didn't go quite to plan, with a 1-1 draw against Rubin Kazan, but he will be hoping his squad can produce the goods against a Saints side that have already won away at Chelsea this season.

Jurgen Klopp didn't have it his own way on his Anfield bow - but he'll hope for more against Southampton

Barcelona vs Eibar - La Liga

Sky Sports 5, air time 5pm

Kick-off 5.15pm

Liverpool game not doing much for you at half-time? Switch over to Sky Sports 5 for some Spanish action. Barcelona and Neymar smashed Rayo Vallecano for five last week but Luis Enrique insists his side still haven't hit top form. They're third in La Liga and face Eibar at the Nou Camp on Sunday, with the visitors impressing this season in seventh.

Neymar scored four goals against Rayo Vallecano last week and Eibar are Barcelona's next opponents

United States Grand Prix - Race

Sky Sports F1, air time 5.30pm

Race start 7pm

Hamilton will enter the Austin track on Sunday knowing that a victory can see him win his third drivers’ championship. He needs to outscore Ferrari's Vettel by nine points, and Mercedes team-mate Rosberg by two. History beckons for the Briton, who can equal the likes of Sir Jackie Stewart and Ayrton Senna with a third world title.