Paralysed patients are able to walk again using virtual reality and brain training in 'suprising' breakthrough

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A woman paralysed for 13 years can now walk again thanks to 'brain training' programmes that restored feeling in her legs.

The 32-year old woman is one of eight people with spinal cord injuries who have improved their condition from full paralysis to partial paralysis thanks to the software.

The 'surprising' clinical results from the Walk Again Project in Sao Paulo, Brazil, show patients have some sensations and muscle control in their legs. 

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 Scientists, led by neuroscientist Dr Miguel Nicolelis, of Duke University in North Carolina, used a virtual reality system which worked with the patients' own brain activity. They patients were taught how to operate their own avatar, to play a game of football in VR

Researchers believe it could offer hope to people who have suffered spinal cord injuries, strokes and other conditions where they will need to regain strength, mobility and independence. 

Scientists, led by neuroscientist Dr Miguel Nicolelis, of Duke University in North Carolina, used a virtual reality system which worked with the patients' own brain activity.

The eight patients spent at least two hours a week using devices controlled through their brain signals.

They were all taught how to operate their own avatar or digital likeness, to play a game of football in a virtual reality environment.

They wore fitted caps lined with 11 non-invasive electrodes to record their brain activity. The patients were asked to imagine walking in the virtual world and it appears that 'the training reinserted the representation of lower limbs into the patients' brains', according to Nicolelis.

He said the therapy forced the patients to create mental imagery of movement - and the more they moved, the more their bodies used surviving nerves that had become dormant from disuse.

The first hopeful signs were spotted in some patients after seven months but the sensations and muscle control reported by four patients were so strong after a year that their doctors upgraded their diagnoses from complete to partial paralysis.

Among those who took part in the rehabilitation training, five people had been paralysed for at least five years while two had been paralysed for more than a decade.

The 32-year-old woman, who has not been named, underwent the most dramatic changes. 

Pictured is a patient using a brain-controlled robotic exoskeleton as part of a trial involving eight people who have been paralysed for years from spinal cord injuries. Researchers report patients regaining some feeling in their legs after training with VR robots

After the initial training, more challenging physical equipment was later introduced to further test patients' control over their posture, balance and ability to use upper limbs. These included walking devices and overhead harnesses

Her condition improved from being unable to stand to being able to walk using a walker, braces and her therapist's help.

At 13 months the patient was able to move her legs voluntarily while her body weight was supported in a harness.

Mr Nicolelis said: 'One previous study has shown that a large percentage of patients who are diagnosed as having complete paraplegia may still have some spinal nerves left intact.

'These nerves may go quiet for many years because there is no signal from the cortex to the muscles.

'Over time, training with the brain-machine interface could have rekindled these nerves.

'It may be a small number of fibres that remain, but this may be enough to convey signals from the motor cortical area of the brain to the spinal cord.'

A computer monitor in the lab of Dr Miguel Nicolelis, shows the brain activity of a monkey using a brain-machine interface. The system simulated control of the patients' legs during the long-term training programme

The therapy forced the patients to create mental imagery of movement - and the more they moved, the more their bodies used surviving nerves that had become dormant from disuse

One of the biggest gains was an improvement on bladder and bowel control for all of the patients.

Speaking as the findings were published in Scientific Reports, he said: 'We couldn't have predicted this surprising clinical outcome when we began the project.

'What we're showing in this paper is that patients who used a brain-machine interface for a long period of time experienced improvements in motor behaviour, tactile sensations and visceral functions below the level of the spinal cord injury.

'Until now, nobody has seen recovery of these functions in a patient so many years after being diagnosed with complete paralysis.'

After the initial training, more challenging physical equipment was later introduced to further test patients' control over their posture, balance and ability to use upper limbs. 

These included walking devices and overhead harnesses.

Previous success from The Walk Again Project include Julian Pinto, a young paraplegic man, being able to kick a football during the 2014 World Cup opening ceremony by using a brain-controlled robotic exoskeleton.

The patients worked with different training systems, including the exoskeleton Mr Pinto wore at the 2014 World Cup.

Mr Nicolelis is an expert in his field having worked for nearly 20 years to build and hone systems that record hundreds of simultaneous signals from neurons in the brain, to extract motor commands and translate them into movement.

Encouraged by the results so far, the research team now hopes that weekly training as part of rehabilitation could help patients re-engage spinal cord nerves that survived the impact of car crashes, falls and other paralysing trauma of the lower limbs.

The progress of the patients, who have now had training for more than two years, will continue to be tracked by the researchers.

The progress of the patients, who have now had training for more than two years, will continue to be tracked by the researchers

 Encouraged by the results so far, the research team now hopes that weekly training as part of rehabilitation could help patients re-engage spinal cord nerves that survived the impact of car crashes, falls and other paralysing trauma of the lower limbs