'OK, third time's the charm!' TNT's beloved sideline reporter Craig Sager braves another bone marrow transplant as he the colorful broadcaster continues to fight his leukemia

TNT's most beloved basketball broadcaster received a rare third bone marrow transplant as an aggressive form of leukemia continues to take its toll. 

The 65-year-old Sager has battled acute myeloid leukemia since 2014, and announced in March that he was no longer in remission. 

These pictures chronicle the hours-long process at MD Anderson Cancer Center in Houston, where Sager received the treatment on Wednesday. 

They show how chemotherapy has diminished Craig Sager's once lustrous chestnut hair to a few unruly strands - and on this day of hope, a simple green T-shirt and blue shorts adorn the man known by millions for his ostentatious wardrobe and easy rapport with the NBA's elite.

He is seen methodically extended a long, skinny arm to an IV pole holding the stem cells he is counting on to save his life. 

There was silence as he cradled the tube, watching the crimson liquid drip, drip, drip in a perfect cadence into the cannula feeding it into his cancer-stricken body. 

Sager knows the odds are against him. Yet, he is unfazed. 

'OK, third time's the charm,' the 65-year-old said moments after the procedure began on Wednesday. 

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Beloved NBA sideline reporter Craig Sager lifts his shirt after starting a bone marrow transplant procedure on Wednesday

Sager holds up his shirt as his wife Stacy takes a picture after starting his transplant procedure

'I like to gamble,' he told The Associated Press. 'I like to bet on horses, I like to bet on dogs, I like to bet on a lot of things. I've bet on a lot of things with a lot higher odds than this.'

Two other times Sager has received a bone marrow transplant with stem cells, and in both instances it put him into remission for several months. 

His son, Craig Sager II, was the donor then. This time, the anonymous 20-year-old donor was considered a perfect match.

Sager has been hospitalized for a month and has another month-long stay ahead. He hasn't thought a lot about the random man whose bone marrow could change everything for him. But when he learned of his age he expressed a possibly only half-serious concern.

'My only thing was I was afraid that when he signed up to be the donor he may have been in some drunk fraternity house, trying to impress his date,' Sager said with a smile. 'And they call him up the next day and say: 'Want to come down to the hospital?' and he's like: 'What?''

Beloved NBA sideline reporter Craig Sager (pictured) has received a rare third bone marrow transplant as he continues his battle against cancer 

NBA Hall of Fame member and TNT colleague Charles Barkley left, bumps fists with sportscaster Craig Sager after visiting Sager on Tuesday

Sager holds a pair of boots that once belonged to Lacey Holsworth while telling a story about their friendship

His fears turned out to be unfounded.

'He came through,' Sager said.

It is the latest of close to 100 procedures Sager has endured in his well-publicized fight.

Sager began the transplant at about 11.30am Central time and it wasn't complete until more than 10 hours later.

Dr. Muzaffar Qazilbash, Sager's stem cell transplantation physician, researched thousands of such transplants at MD Anderson over the last 15 years to illustrate just how uncommon Sager's current procedure is.

'It's less than 1 percent of the total number of transplants,' Qazilbash told the Associated Press. 'It's very rare to have three transplants.'

Sager was in good spirits on Wednesday morning as the process began. 

The 65-year-old speaks about his fight against cancer on Tuesday at MD Anderson Cancer Center in Houston

Sager kisses his wife, Stacy, while undergoing a treatment in Houston on Tuesday

He playfully rolled his eyes at his wife, Stacy, when she chided him for not smiling for a photo where he lifted his shirt to show where the fluid was entering his body in a tube above his left pectoral muscle.

'I'm supposed to be smiling for this?' he asked with a laugh. 'Oh yay!'

Sager, who has long been known for his wacky wardrobe and great relationships with NBA players and coaches, has been very public in his battle with cancer. 

Though he's had to take some time off because of the disease, he's managed to work often since his diagnosis, including April's Final Four in Houston and the NBA Finals in June. 

He was not able to take part in Olympics coverage in Rio, which would have marked his fifth time at the Games.

Sager, who has worked for TNT for more than three decades, calls himself coachable and said he's open to trying anything doctors believe might help.

Senior Clinical Cell Therapy Specialist Megan Raggio prepares stem cells from bone marrow before they are transplanted into Sager

Sager, center, watches as nurse Diana Castillo, left, and Dr. Richard Champlin, right, start the transplant procedure

Sager watches the flow of stem cells after starting his transplant procedure at MD Anderson Cancer Center in Houston

'I've had every chemo in the alphabet, most of them more than once,' he said. 'Some of them that aren't even in the alphabet, they're just numbers — clinical trials. But I bet if you added all those up it would have to be like 60- or 70-something. I've had 23 bone marrow aspirations. Having one isn't fun and I've had 23. So that's been tough.'

Despite the rigors of treatment and how they can ravage his body, he's never thought about giving up. In fact, he gets angry when he meets other patients who say they're grown weary of fighting.

'Man, life is too beautiful, too wonderful, there's just too many things,' he said. 'It's not just you. It's your family and kids and all. Fight. Fight until the end. Fight as hard as you can.'

With his radiant smile and TV-perfect persona it takes time to peel back the layers of positivity and catch a glimpse of how hard that fight can be.

'His attitude is (that) nobody wants to hear it,' said Stacy Sager, his wife, full-time caregiver and No. 1 fan. 

'And so it makes you reflect on yourself and the things that you say when you're complaining about little things in life and trivial things and it just puts things in perspective.'

But there are times, often as night creeps into early morning, where it all becomes too much. No medication can help.

Sager underwent his third bone marrow transplant as he continues to battle leukemia

Sager watches the flow of stem cells after starting his transplant procedure which lasted more than 10 hours

'I've never had any of those days where I've actually said why me, or I can't do it,' he said. 'But I'll have some dark nights where I'll be here by myself and maybe getting some medicine that's making me jump around like a rabbit. 

'And I'm in pain and I've got chills and I've got fever and I've got everything mixed into one and I'm throwing up and have diarrhea ... and I'll just say: 'Stacy, I need you. I need you.'

'And she'll come to me and just hold me and it just makes it better,' he said.

A few days before his transplant, Stacy came down with a bad cold and doctors sent her home, fearful she'd transmit her illness to her husband. Hall of Famer and TNT colleague Charles Barkley heard she couldn't be there for a couple of days and hopped on a plane from Phoenix.

The problem was that Sir Charles had hip replacement surgery less than a month ago and wasn't cleared to travel. He said his doctor was livid when he learned Barkley had defied orders and flown halfway across the country. Barkley informed the doctor that it was an emergency — though it was hard to know who was there for whom.

He doesn't expect to have recovered from Wednesday's transplant in time for the season-opener on October 25

Sager has found inspiration in a little girl who lost her fight with cancer before her ninth birthday. Above, he holds the girl's boots as he talks about their friendship

'Craig Sager is one of the most interesting people I've ever met,' Barkley said. 'We go to see Sager to cheer him up and by the time you leave you're like, 'Is anything wrong with him?' He has the most positive attitude ... when you go to try and cheer him up his attitude is so upbeat he cheers you up.'

Sager has found inspiration in a little girl who lost her fight with cancer before her ninth birthday. He befriended Lacey Holsworthand her family while working on a story about her illness and remained friends with her parents after she died in April 2014. Holsworth had cheered on the Michigan State basketball team and had a close friendship with star Adreian Payne.

Last weekend, her parents visited Sager in his Houston hospital room. They left him with a more tangible reminder of her bravery.

'They brought me little Lacey's boots that she used to always wear to games and a picture of her wearing them,' Sager said, clutching the high-top cheetah footwear accessorized with laces made from silk ribbons. 

'That little girl was so amazing. Fought for all of those years, was always positive, always cheerful, always brought other people's spirits up. So if I'm laying here feeling bad, I just think about Lacey and it puts everything in perspective.'

Sager is also bolstered by his drive to be back on the sideline for the NBA season. 

He doesn't expect to have recovered from Wednesday's transplant in time for the season-opener on October 25, but aims to return by early November for more of the gentle sparring with the likes of Spurs coach Gregg Popovich .

Sager poses with the Jimmy V Perseverance Award at the 2016 ESPYS in July (right) and with his son Craig Sager II (left)

Sager interviews LeBron James after the Cleveland Cavaliers won the NBA Championship game in June this year 

Sager is pictured left, interviewing Kobe Bryant, and right, Tyreke Evans, in 2010, four years before his cancer diagnosis

It would be a victory not just for him, but for all the people his fight has inspired.

'It means that you're surviving and you're winning,' he said. 'That you're knocking down obstacles and clearing hurdles that are put in front of you and you're doing them with flying colors.'

On Wednesday, five colorful balloons were tied to one side of his hospital bed. Several had birthday greetings and two said: 'Happy birthday, it's your big day.'

Festive, yes. But Sager was born in June.

'When you get stem cells they say it's your new birthday,' Stacy explained. 'So this is his fourth birthday.'

Sager tried to downplay the pageantry surrounding the event, saying it wasn't 'a big deal.'

That earned a sweet, yet stern, admonishment from his beloved wife.

'It is a big deal,' she said. 'It's giving you life.'