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Eric Dane in Twitter spat with Grey's Anatomy showrunner Shonda Rhimes over response to Donald Trump's lewd comments

Published: 16:06 EST, 8 October 2016 | Updated: 22:40 EST, 8 October 2016

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They haven't worked together since he quit Grey's Anatomy in 2012.

But on Saturday Eric Dane and showrunner Shonda Rhimes got into a spat on Twitter over reaction to Donald Trump's leaked lewd comments about women.

'Men, stop with ‘we have wives, daughters’ as reason not to condone his actions. You don’t condone his acts becuz you know right from wrong,' Rhimes, 46, tweeted.

Not seeing eye to eye: Grey's Anatomy showrunner Shonda Rhimes and the show's former star Eric Dane got into a Twitter spat Saturday over Donald Trumps lewd comments about women

Dane, 43, seemed to take umbrage with his former boss' opinion.

He tweeted back: 'How bout this – f*** @realDonaldTrump and I could give no fux about @shondarhimes opinion. My wife and 2 girls. He needs to b b***h slapped.'

That prompted a one word response from Rhimes: 'um?'

The tweet that started it: Rhimes tweeted her opinion that men should stop saying they were anti Trump because of the women in their lives, but because it was simply the right thing to do

Hit back: Dane responded via Twitter saying he didn't care about her opinion, prompting a one word response from his former boss

After several hours during which fans peppered him with tweets asking why he was feuding with Rhimes over Trump, given they both think the Republican presidential nominee's remarks were 'disgusting,' the actor returned to Twitter.

'Settle down people I luv @shondarhimes,' he tweeted. 'But @realDonaldTrump? Cmon folks, are you crazy? Are you really supporting this ass? Wake the f*** up!'

Dane, the star of TNT's The Last Ship, has been married to actress Rebecca Gayheart since 2004.

They have two daughters, Billie, six, and Georgia, four.

Settle down people: After a few hours, during which he was peppered with tweets about his attitude, the actor clarified his stance saying he wasn't feuding with Rhimes

Family man: Dane has been married to actress Rebecca Gayheart since 2004 and they have two daughters, Billie, six, and Georgia, four. The family is pictured in April in Hollywood