'Fight like a girl!' Shannen Doherty shares sweet note thanking Chelsea Handler for her support during cancer battle

She's been open about her battle with breast cancer, sharing struggles, triumphant moments, and glimpses at her treatment.

And on Sunday Shannen Doherty took a moment to shout out to her support system, this time focusing on friend Chelsea Handler, 41.

The 45-year-old shared a sweet selfie alongside her friend, as well as a heartfelt message, gushing: 'This one just wants to make a difference.'

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Supportive: Shannen Doherty shared a heartfelt post on Sunday about friend Chelsea Handler, who has been there for her during cancer battle

The stars both showed off their natural beauty in the snap, sporting little to no make-up, while Shannen donned a patterned, blue head scarf.

Chelsea wore her blonde locks in a center part, and styled in soft waves, and showed off a big smile for the snap with her pal.

Alongside the sweet image, Shannen praised her supportive friend, posting: 'And then there is this lady.... @chelseahandler We met many many years ago. Have run into each other and always exchanged numbers, talked of plans etc.'

In good company: Earlier this week another famous friend, Sarah Michelle Gellar, posted her own photo and sweet message, praising Shannen as well as her doctor, Dr. Piro

By her side: Shannen's mother, Rosa, has also been part of Shannen's support system during her difficult battle

'Chelsea reached out and has since, made a point to have date nights with me on a weekly basis. Yeah she's funny but also wicked smart with a huge heart,' Shannen continued.

She concluded: 'Sometimes the right people come into your life at the right time. #girlpower #fightlikeagirl.'

But Chelsea isn't the only famous friend who has Shannen's back, as longtime pal Sarah Michelle Gellar has continued to make her support known.

Her other half: And Shannen just traveled to Mexico to celebrate her five-year wedding anniversary with husband Kurt Iswarienko, who is always by her side

She often posts about the Charmed star, gushing about how brave and strong she is throughout her difficult battle.

Earlier this week she shared a smiling photo with Shannen, calling her 'my friend who is kicking cancer in the you know what.'

'But more than that, she is sharing her battle, so people fighting this horrible disease know they are not alone. I am inspired by her on the daily,' SMG added.

Painfully honest: Shannen has been documenting her treatments, struggles, and triumphant moments to help others as she battles the disease

She also urged her followers to get checked or even remind a friend to do the same, as with 'early detection and incredible doctors like Dr Piro [Shannen's doctor], breast cancer can be fought and won.'

And of course, among Shannen's biggest sources of strength are her mom Rosa, and her husband Kurt Iswarienko, with whom she celebrated her five year anniversary last week in Mexico.

The star continues to document her battle on social media, having done so since sharing the devastating news that the breast cancer she discovered in March 2015 had spread beyond her lymphatic system.

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