The Science of Cellular Health

Worldwide Studies and Research

The following is a list of important Clinical Studies that document the paramount importance of micronutrients and nutrition in maintaining optimum health.

Together with our Cellular Health and WHO Documents pages, it will be hard for you to find a more comprehensive "library" on the health benefits of vitamins, micronutrients and nutrition in the battle against today's most common diseases of the industrialized and the developing world.

In documenting these studies and reports we have taken great care to include studies from the earliest years possible. We did this to document that an abundance of knowledge and scientific data on natural health has been available for 50, 60, 70 even 80 years.

It is no coincidence that this knowledge was ignored, hidden and even obstructed. All this happened in the interest and on behalf of a growing influence of the pharmaceutical investment "business with disease". This influence reached out to the medical schools, media and politicians worldwide.

Imagine, if this natural health information had not have been suppressed by the "business with disease" for decades. How many lives could have been saved?

Don't you think it is time for change? We encourage you to use the following health information whether you are a patient, health professional or politician, whether you are living in an industrialized country or in a developing country.

Scientific Publications by Dr. Rath

Most importantly, his groundbreaking discoveries in the field of medicine will improve the health and life of all people for generations to come.

A Specific Combination Of Ascorbic Acid, Lysine, Proline And Epigallocatechin Gallate Inhibits Proliferation And Extracellular Matrix Invasion Of Various Human Cancer Cell Lines
Shrirang P Netke, M Waheed Roomi, Vadim Ivanov, Aleksandra Niedzwiecki* and Matthias Rath
Matthias Rath, Inc., Research and Development, Santa Clara, CA 95054

Detection and Quantification of Lipoprotein (a) in the Arterial Wall of 107 Coronary Bypass Patients
Matthias Rath, M.D., Axel Niendorf, Tjark Reblin, Manfred Dietel, Hans Joachim Krebber, and Ulrike Beisiegel
ARTERIOSCLEROSIS Vol 9 No 5, SEPTEMBER/OCTOBER 1989

Morphological detection and quantification of lipoprotein(a) deposition in atheromatous lesions of human aorta and coronary arteries
Axel Niendorf, Matthias Rath, Katrin Wolf, Susanne Peters, Hartmut Arps, Ulrike Beisiegel, and Manfred Dietel
Virchows Archives of Pathological Anatomy, 1990, Number 417, Pages 105-111

Lipoprotein (a) in the arterial wall
U. Beisiegel, A. Niendorf, K. Wolf, T. Reblin and M. Rath
EUROPEAN HEART JOURNAL (1990) 11 (SUPPL. E), 174-183

Antiatherosclerotic effect of probucol in WHHL rabbits: are there plasma parameters to evaluate this effect?
B. Finckh¹, A. Niendorf², M. Rath¹, and U. Beisiegel¹
EUR J CLIN PHARMACOL (1991) 40 [SUPPL 1]: S 77 - S 80

Lipoprotein (a) is a surrogate for ascorbate
Matthias Rath M.D. and Linus Pauling Ph.D.
PROCCEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA 1990, 87, 6204-6207

Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig
Matthias Rath M.D. and Linus Pauling Ph.D.

Solution to the Puzzle of Human Cardiovascular Disease: Its Primary Cause is Ascorbate defiency, leading to the deposition of lipoprotein(a) and fibrinogen / fibrin in the vascular wall
Matthias Rath M.D. and Linus Pauling Ph.D.

Apoprotein (a) is an Adhesive Protein
Matthias Rath M.D. and Linus Pauling Ph.D.

Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of this Disease as a Cause for Human Mortality
Matthias Rath M.D. and Linus Pauling Ph.D.

Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs
Matthias Rath M.D. and Linus Pauling Ph.D.

Solution to the Puzzle of Human Evolution
Matthias Rath, M.D.
Journal of Orthomolecular Medicine, August 1992

Lipoprotein(a) Reduction by Ascorbate
Matthias Rath M.D. and Linus Pauling Ph.D.
Journal of Orthomolecular Medicine, August 1992

Reducing the Risk for Cardiovascular Disease with Nutritional Supplements
Matthias Rath, M.D.

A New Era in Medicine
Matthias Rath, M.D.

Puzzle of Human Evolution Solved
Matthias Rath, M.D.
PRESS RELEASE, Journal of Orthomolecular Medicine (November 1992)

Cytotxic Effect of Lipophlic Substitution at 2-, 6-, and 2,6-Positions in Ascorbic Acid and Expression of Matrix Metalloproteinases in Hep G2 Cells, Melanoma Cells and Norman Human Dermal Fibroblast.
M.W. Roomi, S. Netke, V. Ivanov, A. Niedzwiecki and M. Rath
J. Am. Coll. Nutr. 20: 43, 2001

Inhibitory effects of ascorbic acid, proline and lysine supplementation on Matrigel invasion by human breast cancer cells, MDA-MB231.
S Netke, Ph.D., V Ivanov , MD. Ph.D., W. Roomi, Ph. D., A Niedzwiecki, Ph. D., Matthias Rath, M.D.
Presented at: 19th Annual Miami Breast Cancer Conference, Miami Beach, Florida, February 27 – March 3, 2002. Published in: Conference Proceedings

Cellular Medicine Research Breakthroughs in the Control of Diseases: Report on Scientific Research
S Netke, Ph.D., V Ivanov , MD. Ph.D., W. Roomi, Ph. D., A Niedzwiecki, Ph. D., Matthias Rath, M.D.
Presented at: 21st Century Medical Advances in the Treatment of Cancer and Aging, Miami , Fl, March 22-24, 2003; Published in: Conference Proceedings

Nutritional supplement program halts progression of early coronary atherosclerosis.
M. Rath, M.D.
Controversies in Cardiovascular Nutrition, Stanford University Medical Center, Stanford, CA, May 4, 2002

Metastatic and Cytotoxic Effects of Ascorbigen and iso-Ascorbigen in Human Cancer Cell Lines.
M.W. Roomi, A. Bogale, V. Ivanov, S. Netke, A. Niedzwiecki and M. Rath,
J. Am. Coll. Nut. 21: 54, 2002

Matrix Metalloproteinase-2 Inhibition and Invasion Potential in Human Chondrocytes by a natural anti-cancer formula - a Specific Mixture of Nutrients Containing Lysine, Proline, Ascorbic Acid and Epigallocatechin Gallate.
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath and A. Niedzwiecki
Presented at: American Association of Cancer Research Special Conference in Cancer Research: Proteases, Extracellular Matrix and Cancer, Hilton Head Island, South Carolina, Oct 9-13, 2002.

A Natural Anti-Cancer Formula - A Specific Formulation of Nutrients Containing Lysine,Proline, Ascorbic Acid, and Epigallocatechin Gallate Inhibits Matrix Metalloproteinases Activity and Invasion Potential of Human Cancer Cell Lines.
M.W. Roomi, S.P. Netke, V. Ivanov, M. Rath and A. Niedzwiecki
Presented at: European Organization for Research and Treatment of Cancer (EORTC), AACR and NCI Symposium on Molecular Targets and Cancer Therapeutics, Frankfurt, Germany, Nov 19-22, 2002; Published in: European Cancer Journal, 38, Suppl.7/Abs.280, 2002

Antitumorigenic Activity of a Natural Anti-Cancer Formula in Human Breast Cancer Lines MDA-MB-231 and MCF-7.
Roomi, M.W., Ivanov, V., Rath, M. and Niedzwiecki, A.
Presented at: The 8th Annual Multidisciplinary Symposium on Breast Disease, Amelia Island, FL, February 13-16, 2003; Published in: Conference Proceedings

A randomized, double-blind placebo-controlled clinical study documents the benefits of a vitamin program as an adjunct therapy in patients with paraxysmal atrial arrhytmia.
Matthias Rath M.D. and Aleksandra Niedzwiecki Ph.D.
14th Madrid Arrhytmia Meeting, Madrid, Spain, February 27-28, 2003

A novel in vitro bioassay for screening matrix metalloproteinases activity in human cancer cell lines
M Waheed Roomi, Shirang P Netke, Vadim Ivanov, Matthias Rath and Aleksandra Niedzwiecki
Proceedings of the American Association for Cancer Research 44:4559(2003)

Inhibitory Effect of a Natural Anti-Cancer Formula - A Specific Formulation of Nutrients Containing Lysine, Proline, Ascorbic Acid and Epigallocatechin Gallate on the Matrix Metalloproteinases Activities and Invasion of Human Fibrosarcoma HT-1080 Cells
MW Roomi, V Ivanov, SP Netke, M Rath and A Niedzwiecki
FASEB Journal (2003) 8452

Letter to Editor: Antioxidant supplements and simvastatin-niacin therapy.
Netke S, Ivanov V, Roomi W, Niedzwiecki A, Rath M.
Arterioscler Thromb Vasc Biol. (2001) 21, 2099-2100.

Aids / HIV

• December 2015: Micronutrients in HIV: A Bayesian Meta-Analysis
• Effect of micronutrient supplementation on disease progression in asymptomatic, antiretroviral-naive, HIV-infected adults in Botswana: a randomized clinical trial
• Micronutrients: current issues for HIV care providers
• A Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality
• Maternal vitamin A deficiency and mother-to-child transmission of HIV-1.
• Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing agents in chronically HIV-infected cells.
• Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells.
• Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine.
• Results of an open study for evaluating the effectiveness and tolerance of adjuvant administration of the ISF nutrient program in HIV positive patients.
• Micronutrients and HIV-1 disease progression.
• Status of selected nutrients and progression of human immunodeficiency virus type 1 infection.
• Increased uptake and accumulation of vitamin C in human immunodeficiency virus 1-infected hematopoietic cell lines.
• Ascorbate effect on cytokine stimulation of HIV production.
• Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing agents in chronically HIV-infected cells.
• Virological and immunological effects of antioxidant treatment in patients with HIV infection.
• Vitamin supplements may delay AIDS.
• Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study
• Micronutrients and the patogenesis of human immunodeficiency virus infection
• Vitamin A deficiency and the acute phase response among HIV-1-infected and -uninfected women in Kenya.
• L-arginine: a therapeutic option for AIDS/HIV infection?
• Effects of micronutrient intake on survival in human immunodeficiency virus type 1 infection.
• Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects.
• Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial.
• The effect of antenatal vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women.
• The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women.
• Increased glutathione cycling and vitamin E of P. falciparum infected erythrocytes fail to prevent spontaneous haemolysis.
• Impact of massive dose of vitamin A given to preschool children with acute diarrhoea on subsequent respiratory and diarrhoeal morbidity.
• Vitamin/mineral supplementation, the aging immune response, and risk of infection.
• Protective effects of the glutathione redox cycle and vitamin E on cultured fibroblasts infected by Mycoplasma pneumoniae.
• An Association Between Helicobacter pylori Infection and Serum Vitamin B12 Levels in Healthy Adults [In Process Citation]
• Relation among micronutrient intakes with CD4 count in HIV infected patients
• Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women.
• Vitamins and immunomodulation in AIDS.
• Infant mortality and maternal vitamin A deficiency during human immunodeficiency virus infection.
• Increased mortality associated with vitamin A deficiency during human immunodeficiency virus type 1 infection.
• Antioxidant vitamins and immunodeficiency.
• Vitamin B-12 abnormalities in HIV-infected patients.
• Micronutrients and tropical viral infections: one aspect of pathogenic complexity in tropical medicine
• Supplementation with antioxidant vitamins prevents oxidative modification of DNA in lymphocytes of HIV-infected patients
• Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into cellular DNA.
• Serum vitamin A and beta-carotene levels in pregnant women infected with human immunodeficiency virus-1.
• Relation of vitamin A and carotenoid status to growth failure and mortality among Ugandan infants with human immunodeficiency virus.
• A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania.
• The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women.
• Vitamin B12 malabsorption in patients with acquired immunodeficiency syndrome.
• Clinical correlates of subnormal vitamin B12 levels in patients infected with the human immunodeficiency virus.
• Reversal of apparent AIDS dementia complex following treatment with vitamin B12.
• Abnormal vitamin B12 metabolism in human immunodeficiency virus infection. Association with neurological dysfunction.
• Vitamins in HIV disease progression and vertical transmission.
• Abnormal T-cell subset proportions in vitamin-A-deficient children.

Top

Alzheimer's Disease

• Alzheimer's and Vitamin E
• Ascorbic Acid in Cerebrospinal Fluid – A Possible Protection Against Free Radicals in the Brain
• Plasma Concentrations of Vitamins A and E and Carotenoids in Alzheimer's Disease
• Thiamine and Alzheimer's Disease: A Pilot Study
• Inositol Treatment of Alzheimer's Disease: A Double-Blind, Cross-Over Placebo Controlled Trial

Top

Anaemia

• An inter-relationship between ascorbic acid and cyanocobalamin (1958)
• Folic acid and cyanocobalamin in pernicious anemia (1958)
• Anemia in pregnancy
• Comparison of effects of folic acid and folinic acid
  in experimental megaloblastic anemia
• Megaloblastic anemia of pregnancy and the puerperium (1961)
• Megaloblastic anemia during pregnancy and the puerperium (1962)
• Megaloblastic Anemia in Pregnancy (1951)
• Potentiation of Pteroylglutamic acid by ascorbic acid in anemia of scurvy (1953)
• Scorbutic megaloblastic anaemia responding to ascorbic acid alone (1967)
• Experimental megaloblastic anemia and scurvy in the monkey
• Experimental production of megaloblastic anemia; an interrelationship between ascorbic acid and pteroylglumatic acid
• Vitamin E and Anaemia
• The relation of vitamin C deficiency to nutritional anemia
• The anaemia of scurvy
• The anaemia of scurvy (Alexander Brown)
• The anaemia of adult scurvy
• Megaloblastic Anaemai associated with adult scurvy: Report of a case which responded to Synthetic ascorbic acid alone
• Scurvy and Anaemia
• Nutritional factors in the pathogenesis of iron-deficiency anemia
• Relationship of anemia and scurvy
• Agriculture-related anaemias
• Ascorbic acid effect on intestinal iron absorption in different types of anaemias.
• Anaemia among the inhabitants of a rural area in northern Natal.

Top

Asthma

• Magnesium Sulfate Is Effective for Severe Acute Asthma Treated in the Emergency Department
• Vitamin C Helps Reduce Asthma After Exercise
• Selenium Status is Decreased in Patients With Intrinsic Asthma
• Reduced Selenium in Asthmatic Subjects in New Zealand

Top

Bones

• Effect of vitamin c on osteogenesis imperfecta
• The effect of graded doses of vitamin C upon the regeneration of bone in guinea-pigs on a scorbutic diet
• Some experiments on the possible relationship between vitamin C and calcification
• German: Experimentelle Untersuchungen über Beeinflussung der Knochenregeneration durch Vitamin C
• Further studies on the effect of diet upon the teeth and bones
• Ascorbic acid therapy for the relief of bone pain in paget's disease
• Effect of ascorbic acid deprivation in guinea pigs on skeletal metabolism
• Further evidence of skeletal response to exogenous ascorbic acid

Top

Cancer

• Megadose vitamins in bladder cancer: a double-blind clinical trial.
• Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
• Antitumor effect of nutrient synergy on human osteosarcoma cells U-2OS, MNNG-HOS and Ewing's sarcoma SK-ES.1
• The orthomolecular treatment of cancer. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer
• Nutrition and its relationship to cancer
• Enhancement of Random Migration and Chemotactic Response of Human Leukocytes by Ascorbic Acid (1974)
• Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs
• The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii.
• Chemoprevention of bladder cancer.
• Selenium and cancer: some nutritional aspects.
• Vitamin supplements and cancer risk: the epidemiologic evidence.
• Innovation vs. quality control: an 'unpublishable' clinical trial of supplemental ascorbate in incurable cancer.
• Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study.
• Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1.
• Chemoprevention of oral cancer by green tea.
• Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallate.
• Green tea and cancer chemoprevention.
• Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
• [Cancer prevention with green tea: reality and wishful thinking]
• Mechanistic findings of green tea as cancer preventive for humans.
• Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States).
• Diet and pharyngeal cancer.
• Vitamin and mineral supplement use is associated with reduced risk of prostate cancer.
• Vitamin supplement use and reduced risk of oral and pharyngeal cancer.
• Vitamin supplement use and risk for oral and esophageal cancer.
• A short-term dietary supplementation of high doses of vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer.
• Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population
• Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer

More studies on cancer can be found here...

Top

Cardiovascular Diseases

• The effect of chronic hypovitaminosis C on the metabolism of cholesterol and atherogenesis in guinea pigs
• Studies on the role of ascorbic acid on atherosclerosis
• An experimental study of the intimal ground substance in atheroclerosis
• Marginal vitamin C deficiency, lipid metabolism and atherogenesis
• Ascorbate Cholestorol lecithin interactions: factors of potential importance in the pathogenesis of atherosclerosis
• Ascorbic acid and atherosclerosis
• Research in Russia on vitamins and atherosclerosis
• Aging, atherosclerosis and ascorbic acid metabolism
• The role of ascorbic acid in the regulation of cholesterol metabolism and in the pathogenesis of atherosclerosis
• The reversibility of atherosclerosis
• The effect of ascorbic acid on experimental atherosclerosis
• Reassessment of changes in leucocyte and serum ascorbic acid
  after acute myocardial infarction (1978)
• Endothelial changes produced by ascorbic acid deficiency in guinea pigs
• Plasma vitamin A and E in the study of lipid and lipoprotein metabolism in coronary heart disease
• Ischaemic-Heart-Disease mortality and dietary intake of calciam
• Commodity consumption and ischemic heart disease mortality, with special reference to dietary practices
• Site of origin of venous thrombi
• Seasonal variation in the incidence of deep vein thrombosis
• Vitamin C and P in cardiovascular and cerebrovascular disease
• Municipal drinking water and cardiovascular death rates
• Effect of insulin on ascorbic acid uptake by heart endothelial cells: Possible relationship to retinal atherogenesis
• Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis.
• Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease.
• Coronary endothelial function in hyperhomocysteinemia: improvement after treatment with folic acid and cobalamin in patients with coronary artery disease.
• Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease.
• Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate.
• Inverse relation between the concentration of low-density-lipoprotein vitamin E and severity of coronary artery disease.
• Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group.
• Cost-effectiveness of vitamin E therapy in the treatment of patients with angiographically proven coronary narrowing (CHAOS trial). Cambridge Heart Antioxidant Study.
• Plasma levels of antioxidant vitamins and oxidative stress in patients with acute myocardial infarction.
• Vitamin E analogues reduce the incidence of ventricular fibrillations and scavenge free radicals.
• Effects of dietary supplementation with alpha-tocopherol on myocardial infarct size and ventricular arrhythmias
• Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women.
• Usefulness of antioxidant vitamins in suspected acute myocardial infarction.
• Status of myocardial antioxidants in ischemia-reperfusion injury.
• Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction.
• Effect of homocysteine-lowering therapy with folic acid, vitamin B(12), and vitamin B(6) on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial.

Top

Cholelithiasis

• German: Zur Pathogenese, Prohylaxe und Regression der Cholelithiasis

Top

Cholera

• Impaired mucosal antibody response to cholera toxin in vitamin A-deficient rats immunized with oral cholera vaccine.

Top

Common Cold

• Vitamin C and the common cold: a double-blind trial
• The effects of ascorbic acid and flavonoids on the occurence of symptoms normally asscociated with the common cold
• Ascorbic acid and the common cold
• Vitamin C and the common cold
• Blood ascorbic level in bioflavonoid and ascorbic acid therapy of common cold
• Usefulness of bioflavonoids and ascorbic acid in treatment of common cold
• Blood ascorbic acid level in bioflavonoid and ascorbic acid therapy of common cold

Top

Dental

• Vitamins as an adjunct in the treatment of of periodontal disease
• The effect of ascorbic acid supplementation on tooth mobility
• The relation of ascorbic acid intake to gingivitis
• Relation of diet to general health and particularly to inflammation on the oral tissues and dental caries
• Effect of increased ascorbic acid blood levels on the ascorbic acid level in treated and non-treated Gingiva
• Local and systemic influences in periodontal disease
• Dental treatment in the Third World
• Effect of prophylaxis and vitamin supplementation upon periodontal index in children
  Dentist need more vitamin C?
• Therapeutic effect of water-soluble bioflavonoids in gigival inflammatory conditions
• Relationship of blood plasma vitamin C level to gingival and periodontal disease
• The effect of ascorbic acid deficiency on enamel formation in the teeth of guinea pigs
• The therapeutic application of vitamin C in peridental disease
• Relationship of blood plasma vitamin C level
  to gingival and periodontal disease (1942)

Top

Diabetes

• Observations on the effect of rutin and hesperidin in diabetic retinitis
• The diabetogenic effect of dehydroascorbic and dehydroisoascorbic acids
• The effect of ascorbic acid on the corbohydrate metabolism
• Ascorbic acid metabolism in diabetes mellitus (Roger E. Pecoraro)
• Ascorbic acid metabolism in diabetes mellitus (S.Som)
• Carbohydrate metabolism in ascorbic acid deficiency
• Carbohydrate metabolism in the ascorbic acid-deficient guinea pig under normal and anoxic conditions
• Decreased platelet vitamin C in diabetes mellitus: Possible role in hyperaggregation
• Diabetes and Periodental Disease: Possible role of vitamin C deficiency: An Hypothesis
• Vitamin C supplements and diabetic cutaneous capillary fragility
• The hypoglycemic effect of ascorbic acid in a juvenile-onset diabetic
• Hypocholesterolemic effect of ascorbic acid in maturity-onset diabetes mellitus
• Hypothesis: The role of vitamin C in diabetic angiopathy
• Vitamin C in the treatment of diabetes
• Neuretic manifestations in diabetes mellitus
• Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus.
• Effect of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride levels and red cell indices in type I diabetic patients.
• Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
• A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy.
• Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men.
• High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes.
• Diabetes mellitus is controlled by vitamin C treatment.
• Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation
• A deficiency of vitamin B6 is a plausible molecular basis of the retinopathy of patients with diabetes mellitus.
• Vitamin E reduction of protein glycosylation in diabetes. New prospect for prevention of diabetic complications?
• Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus.
• Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in Type 2 diabetic patients.
• Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes.
• Effects of long-term supplementation with moderate pharmacologic doses of vitamin E are saturable and reversible in patients with type 1 diabetes.
• Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
• Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children.
• German: C-Vitamin und Diabetes
• German: Ist der Diabetes durch die Vitamine B und C beeinflußbar?
• German: Studien über den Einfluss von Vitamin B1 und C auf den Blutzucker de Diabetikers
• German: Über den Einfluß von l-Askorbinsäure (Vitamin C) auf Diabetes mellitus
• German: Diabetes und Vitamin C
• German: Vitamin C und Blutzucker

Top

Drugs

• Modification of drug biotransformation by vitamin C in man
• Metabolic interactions between l-ascorbic acid and drugs

Top

Endocrinology

• The pathogenesis of deficiency disease
• Ascorbic acid deficiency and pituitary adrenocortical activity in the guinea-pig

Top

Eye Diseases

• The importance of keratomalacia as a cause of blindness in India
• Aqueous humor ascorbate concentration and open-angle glaucoma
• Ascorbic acid and the eye with special reference to the lens
• Experimental contribution to the study of the relation between night blindness and malnutrition
• The pressure lowering effect of ascorbic acid in ocular hypertension
• Vitamin C and its relation to cataract
• Vitamin C and the aging eye
• Nutritional diseases and the eye, the role of vitamin B
• Optic neuritis and vitamin B
• Malnutrition as an etiological factor in senile cataract (1952)

Top

Gynaecology

• The management of abnormal vaginal bleeding (1942)
• Treatment for excessive uterine bleeding (1961)
• Capillary strength of women with menorrhagia (1962)
• Ascorbic acid metabolism in preeclampsia
• Relationships of ascorbic acid to pregnancy, and oral contraceptive steroids
• A treatment for excessive uteringe bleeding
• Capillary strength and the menstrual cycle
• Comparison of blood levels of vitamin A, ß-Carotene and vitamin E in abruptio placentae with normal pregnancy
• Dietary requirements for fertility and lactation

Top

Heart Failure

• L-carnitine treatment for congestive heart failure--experimental and clinical study.
• A randomised, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction.
• Controlled study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure.
• Acute and chronic effects of propionyl-L-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure.
• A randomised, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction.
• Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure (interim analysis). The CoQ10 Drug Surveillance Investigators.
• Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.
• Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone).
• Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials.
• Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: effects of short-term coenzyme Q10 treatment.
• The clinical and hemodynamic effects of coenzyme Q10 in congestive cardiomyopathy.
• Usefulness of coenzyme Q10 in clinical cardiology: a long-term study.
• Randomized, double-blind, placebo-controlled study of ascorbate on the preventive effect of nitrate tolerance in patients with congestive heart failure.
• Role of oxidative stress in transition of hypertrophy to heart failure.
• Neutrophil superoxide anion--generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy.
• Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure.
• Dietary and blood antioxidants in patients with chronic heart failure. Insights into the potential importance of selenium in heart failure.
• Vitamin C inhibits endothelial cell apoptosis in congestive heart failure.
• Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy.
• Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone).

Top

Hepatitis

• Efficacy of vitamin E and sodium selenite in experimental hepatic dystrophy
• Vitamin B12 and hepatitis C: molecular biology and human pathology.
• Vitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trial.
• Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C: a randomized, double-blind, placebo-controlled study.
• The use of water-soluble vitamins in viral hepatitis A

Top

High Blood Pressure

• Combination oral antioxidant supplementation reduces blood pressure.
• Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons.
• Disturbed calcium metabolism in subjects with elevated diastolic blood pressure.
• Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension.
• A randomized, double-blind, controlled trial of vitamin C in the management of hypertension and lipids.
• Ascorbic acid, blood pressure, and the American diet.
• Ascorbic acid status and subsequent diastolic and systolic blood pressure.
• L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release.
• Oral arginine improves blood pressure in renal transplant and hemodialysis patients.
• Comparison among the effects of arginine, a nitric oxide precursor, isosorbide dinitrate and molsidomine, two nitric oxide donors, on hormonal secretions and blood pressure in man.
• Blood pressure and metabolic changes during dietary L-arginine supplementation in humans.

Top

Immune System

• NEW: Immune-enhancing role of vitamin C and zinc and effect on clinical conditions
• Vitamin C and immunity: an assessment of the evidence
• Vitamin C and immunity: Natural Killer (NK) Cell Factor
• Vitamin C, interferon and the immune response
• Effect of mega doses of vitamin C on bactericidal ativity of leukocytes
• A Systematic study of the effect of vitamin C supplementation on the humoral immune response in ascorbate-dependent mammals
• The relationship between ascorbic acid and phagocytic activity
• Modulation of certain immunologic responses by vitamin C
• Ascorbate-mediated stimulation of neutrophill motility and lymphocyte transformation by inhibition of the peroxidase halide system in vitro and in vivo
• Acorbic acid and immunity: III The effect of ascorbic acid upon the bactericidal action of human blood
• Vitamin C and Immunity:Influence of ascorbate on prostaglandin E2 synthesis and implications for natural killer cell activity
• Ascorbic acid and immunity: The relation of ascorbic acid to human complement
• Vitamin C and immunity
• Single nutrients and immunity
• Histamine and ascorbic acid in human blood (1980)
• Ascorbic Acid and blood coagulation (1960)
• Effect of mega doses of vitamin C on bactericidal ativity of leukocytes (1977)
• Leucocyte ascorbic acid and pressure sores in paraplegia (1972)
• The blood picture in scurvy, with particular reference to the platelet (1921)
• The determination of ascorbic acid in white blood cells (1961)
• The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers
• Ascorbic Acid: Immunological effects and hazards
• The effect of vitamin C deficiency on complement systems and complement components
• Inhibition of histamine-induced airway constriction by asorbic acid
• Vitamin C and Immunity (1948)
• Ascorbic acid and the production of antibody in the guinea-pig
• Role of vitamin C in resistance
• Complement activity and vitamin C
• Ascorbic acid as a precursor of serum complement
• The Effect of Ascorbic Acid Suplementation on some Parameters of the Human Immunological Defence System (1977)

Top

Infectious Diseases

• Diet, nutrition and infection (1932)
• Virus interference. I. The interferon (1957)
• The administration of vitamin C in a large institution and its effects on general health and resistance to infection
• The effect of administration of vitamin C on the reticulocytes in certain infectious diseases
• The use of citrus flavonoids in infections. II
• Vitamin A as an anti-infective agent
• Infection as cause of folic acid deficiency and megaloblastic anemia
• Clinical Research: Infection Disease
• Prolonged upper respiratory infections
• Killing and lysis of gram-negative bacteria through the synergistic effect of hydrogen peroxide, ascorbic acid, and lysozyme
• The relation of vitamin c to bacterial infection
• Inactivation of diphtheria toxin in vivo and in vitro by crystalline vitamin C (Ascorbic Acid).
• Resistance of the avitaminic albino rat to diphtheria toxin; production of antitoxin and blood pressure effects
• The influence of vitamin C level upon resistance to diphtheria toxin
• Inhibitive effect of vitamin C on toxin production by C. diphtheria
• The influence of purulent infection on the development of experimental scurvy
• The relation of vitamin C deficiency to intestinal tuberculosis in the guinea pig
• Serum vitamin A levels in respiratory syncytial virus infection.
• Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania.
• High-level dietary vitamin A enhances T-helper type 2 cytokine production and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice.
• Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice.
• Serum vitamin A and beta-carotene levels in children with recurrent acute respiratory infections and diarrhoea in Malatya.
• Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress.
• A to Z: vitamin A and zinc, the miracle duo.
• Effect of vitamin A deficiency on the early response to experimental Pseudomonas keratitis.
• Lymphocyte subpopulations in children with vitamin D deficient rickets.
• Interrelation of vitamin C, infection, haemostatic factors, and cardiovascular disease.
• Vitamin A deficiency predisposes to Staphylococcus aureus infection.
• Lymphocyte subpopulations in children with vitamin D deficient rickets.
• Dietary vitamin A intake and the incidence of diarrhea and respiratory infection among Sudanese children.
• Vitamin A supplementation improves macrophage function and bacterial clearance during experimental salmonella infection.
• Effect of infection on nutrient requirements.
• Iron deficiency in the tropics.
• A health and nutritional profile of rural school children in KwaZulu-Natal, South Africa.
• Nutritional requirements in parasitic diseases.
• The use of the Multi-Tabs vitamin and mineral complex to prevent influenza
• Vitamin E status, glutathione peroxidase activity and the effect of vitamin E supplementation in children with thalassemia.
• Anemia in pregnancy in rural Tanzania: associations with micronutrients status and infections.
• Micronutrient concentrations in the HIV wasting syndrome.
• Micronutrient deficiencies in the preterm neonate.
• Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects.
• Epidemiology of uterine cervical cancer.
• Micronutrients and infectious diseases: thoughts on integration of mechanistic approaches into micronutrient research.
• Serum concentration of micronutrients in relation to schistosomiasis and indicators of infection: a cross-sectional study among rural Zimbabwean schoolchildren.
• Micronutrient malnutrition, infection, and immunity: an overview.
• Respiratory infections reduce the growth response to vitamin A supplementation in a randomized controlled trial.
• Micronutrients and the pathogenesis of human immunodeficiency virus infection.
• Micronutrients and tropical viral infections: one aspect of pathogenic complexity in tropical medicine
• A health and nutritional profile of rural school children in KwaZulu-Natal, South Africa.
• Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children
• Micronutrient antioxidants in gastric mucosa and serum in patients with gastritis and gastric ulcer: does Helicobacter pylori infection affect the mucosal levels?
• Malnutrition and immunodeficiency in children
• Micronutrient profiles in HIV-1-infected heterosexual adults.
• Micronutrient levels in HIV-1-infected children.
• Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania.
• Predictors of micronutrient status among six- to twelve-month-old breast-fed Ghanaian infants.
• Infectious Diseases
• Nutrition and immune function in human immunodeficiency virus infection.
• Micronutrient supplementation and immune function in the elderly.
• Viral characteristics of human papillomavirus infection and antioxidant levels as risk factors for cervical dysplasia.
• Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects.
• The health and nutritional status of schoolchildren in Africa: evidence from school-based health programmes in Ghana and Tanzania. The Partnership for Child Development.
• Plasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia.
• Nourishing the HIV-infected adult.
• Etiology of anemia in pregnancy in south Malawi.
• Malnutrition, morbidity and mortality in children and their mothers.
• Antiviral activity of flavones and potentiation by ascorbate.
• Ascorbate stabilizes the differentiated state and reduces the ability of Rous sarcoma virus to replicate and to uniformly transform cell cultures.
• Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus.
• In vitro inactivation of human immunodeficiency virus by ascorbic acid.
• In vitro inhibition of human cytomegalovirus replication in human foreskin fibroblasts and endothelial cells by ascorbic acid 2-phosphate.
• Mechanistic aspects of ascorbate inhibition of human immunodeficiency virus.
• NF-kappa B-independent suppression of HIV expression by ascorbic acid.
• Rapid inactivation of bacteriophage T7 by ascorbic acid is repairable.
• Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells.
• The effect of ascorbic acid on infection chick-embryo ciliated tracheal organ cultures by coronavirus.

Top

Irregular Heart Beat

• Hypomagnesemia in heart failure with ventricular arrhythmias. Beneficial effects of magnesium supplementation.
• Ventricular arrhythmias late after myocardial infarction are related to hypomagnesemia and magnesium loss: preliminary trial of corrective therapy.
• Vigorous supplementation of a hypocaloric diet prevents cardiac arrhythmias and mineral depletion.
• Beneficial effects of vitamin E treatment in acute myocardial infarction.
• Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian experiment of infarct survival-3).
• Plasma levels of antioxidant vitamins and oxidative stress in patients with acute myocardial infarction.
• Carnitine and its role in cardiovascular disease.
• Therapy of arrhythmia induced by myocardial ischemia. Association of L-carnitine, propafenone and mexiletine
• Magnesium deficiency. Role in arrhythmias complicating acute myocardial infarction?
• Plasma levels of antioxidant vitamins and oxidative stress in patients with acute myocardial infarction.
• Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian experiment of infarct survival-3).

Top

Joint Diseases

• Vitamin B Complex Therapy in Chronic Arthritis
• Effect of ascorbic acid on rheumatoid factor
• Studies relating vitamin C deficiency to rheumatic fever and rheamatoid arthritis; experimental, clinical and general consideration
• GAG for osteoarthritis of the knee--a prospective study
• Anti-arthrosis treatments: efficacy and tolerance of chondroitin sulfates (CS 4&6)
• The effect of niacinamide on osteoarthritis: a pilot study.
• High dosage therapy in patients with activated arthrosis
• Tocopherol in Osteoarthritis: a controlled pilot study
• Tranexamic acid, an inhibitor of plasminogen activation, reduces urinary collagen cross-link excretion in both experimental and rheumatoid arthritis.
• Oxidant/antioxidant status of plasma samples from patients with rheumatoid arthritis.
• Oxidant-antioxidant imbalance in blood of children with juvenile rheumatoid arthritis.
• Selenium concentration in erythrocytes of patients with rheumatoid arthritis. Clinical and laboratory chemistry infection markers during administration of selenium.

Top

Leishmaniasis

• Vitamin A serum level in children with visceral leishmaniasis
• Alterations of serum selenium, zinc, copper, and iron concentrations and some related antioxidant enzyme activities in patients with cutaneous leishmaniasis.
• Interaction of ascorbate and alpha-tocopherol enhances antioxidant reserve of erythrocytes during anemia in visceral leishmaniasis.
• Vitamin A serum level in children with visceral leishmaniasis
• Alterations of serum selenium, zinc, copper, and iron concentrations and some related antioxidant enzyme activities in patients with cutaneous leishmaniasis.

Top

Leprosy

• Nutrition in leprosy: a review.
• Undernutrition and lepromatous leprosy. Serum vitamin A and E levels in leprosy spectrum.

Top

Lipid Metabolism

• Ascorbic acid in cholesterol and bile acid metabolism
• Vitamin C therapy in hyperlipoproteinemia
• The effect of ascorbic acid on cholesterolemia in healthy subjects with seasonal deficit of vitamin C
• Dietary ascorbic acid and serum cholesterol

Top

Liver Disease

• Ascorbic acid deficiency in liver disease
• Vitamin C for prophylaxis of viral hepatitis B in transfused patients
• German: Hepatitistherapie mit Ascorbinsäureinfusionen

Top

Malaria

• Hookworms, malaria and vitamin A deficiency contribute to anemia and iron deficiency among pregnant women in the plains of Nepal.
• Association between measures of vitamin A and the ocular fundus findings in cerebral malaria.
• Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth.
• Antioxidant status and acute malaria in children in Kampala, Uganda.
• Malaria is associated with reduced serum retinol levels in rural Zambian children.
• Nutritional modulation of malaria morbidity and mortality.
• Nutritional status and nutrient intake of preschool children in northern Ghana.
• Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth.
• Vitamin A supplementation in northern Ghana: effects on clinic attendances, hospital admissions, and child mortality. Ghana VAST Study Team.
• Mechanism of protection induced by vitamin A in falciparum malaria.
• Vitamin A deficiency in pre-school age Congolese children during malarial attacks. Part 2: Impact of parasitic disease on vitamin A status.

Top

Measles

• Vitamin a supplementation of vitamin a deficient measles patients lowers the risk of measles-related pneumonia in zambian children.
• Vitamin A levels and severity of measles.
• Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles.
• Vitamin A for preventing secondary infections in children with measles--a systematic review.
• [Gunstige effecten van vitamine A bij mazeleninfectie.]
• Micronutrients and tropical viral infections: one aspect of pathogenic complexity in tropical medicine
• Vitamin A for preventing secondary infections in children with measles--a systematic review.
• Routine high-dose vitamin A therapy for children hospitalized with measles.
• Measles severity and serum retinol (vitamin A) concentration among children in the United States.
• Measles severity and serum retinol (vitamin A) concentration among children in the United States.
• The efficacy of oral vitamin A supplementation for measles and respiratory syncytial virus (RSV) infection
• Vitamin A supplementation and child mortality. A meta-analysis.
• Childhood mortality after a high dose of vitamin A in a high risk population.
• A randomized, controlled trial of vitamin A in children with severe measles.
• Recommendations for vitamin A supplementation
• Vitamin A supplementation: implications for morbidity and mortality in children.

Top

Metabolism

• Sparing action of fat on the antineuritic vitamin B
• The influence of insulin on the distribution of glycogen in normal animals
• Contributions to the study of brain metabolism
• Ascorbic acid and the metabolism of the aromatic amino acids

Top

Multiple Sclerosis

• Oxidative stress in patients with multiple sclerosis
• High prevalence of vitamin D deficiency and reduced bone mass in multiple sclerosis
• High Dose Antioxidant Supplementation to MS Patients: Effects on Glutathione Peroxidase, Clinical Safety, and Absorption of Selenium
• Homocysteine and Vitamin B12 in Multiple Sclerosis

Top

Nutrition

• Vitamins in human nutrition (1936)
• Tropical Diseases arising from Dietetic Deficiency (1930)
• The Relation of diet to health and disease (1930)
• Biological food tests: Vitamin A in three varieties of cheese
• Diet, Nutrition and Infection
• Further experiments on the influence of food upon longevity
• Malnutrition as an etiological factor in senile cataract
• Nutrition studies
• The relation of diet to health and disease
• The antiscorbutic fraction of lemon juice I
• The antiscorbutic fraction of lemon juice II
• The antiscorbutic fraction of lemon juice III
• The antiscorbutic fraction of lemon juice IV
• The antiscorbutic fraction of lemon juice VIII
• The anitscorbutic potency of apples
• The influence of food upon longevity
• The preparation and properties of vitamin C concentrates from lemon juice
• The preservation of the antiscorbutic vitamin in lemon juice
• Tropical diseases arising from dietetic deficiency
• Newer aspects of some nutritional disorders
• The Vanderbilt cooperative study of maternal and infant nutrition
• German: Lassen sich in Sauglingsheimen Ersparnisse durch die Konservierung von Gemüsesäften erzielen?
• German: Sauerkraut als C-Vitaminträger
• The essential factors in the diet during growth
• White rice as a causative agent of Beri-Beri

Top

Osteoporosis

• Osteoporosis in Johannesburg Bantu Males

Top

Psychiatry

• Orthomulecular Psychiatry
• Ascorbic acid in chronic psychiatric patients- A contolled trial

Top

Severe Acute Respiratory Syndrome (SARS)

• Find out more about SARS here...

Top

Schistosomiasis

• Potential lifestyle and dietary supplement options for the prevention and postdiagnosis of bladder cancer.
• Interaction between supplemented selenium and/or vitamin E and Mn, Zn, Fe, and Cu in Schistosoma infected mice.
• Complications of human schistosomiasis and their effect on levels of plasma copper, zinc and serum vitamin A.
• The relationship between serum carnitine levels and the nutritional status of patients with schistosomiasis.
• Vitamin A status in different stages of schistosomal cases and the effectiveness of oral vitamin A therapy.
• The influence of the regional basic diet from northeast Brazil on health and nutritional conditions of mice infected with Schistosoma mansoni.
• The impact of zinc supplementation on Schistosoma mansoni reinfection rate and intensities: a randomized, controlled trial among rural Zimbabwean schoolchildren.
• The interaction of zinc and vitamin A in human schistosomiasis.
• The effect of zinc deficiency on granuloma formation, liver fibrosis, and antibody responses in experimental schistosomiasis.
• Serum concentration of micronutrients in relation to schistosomiasis and indicators of infection: a cross-sectional study among rural Zimbabwean schoolchildren.

Top

Scurvy

• Experimental scurvy in man
• Carbohydrate and lipid metabolism in scurvy: Effect of vitamin C supplement
• Effect of vitamin C on a scorbutic type gingival lesion
• Scorbutic arthropathy in the guinea pig
• What's new about scurvy?
• Dutch: Over een aanleiding tot de studie der Experimenteele Scheurbuik en het wezen der anaemi bij deze ziekte
• Chemistry of the blood in scurvy
• German: Beiträge zur Biochemie der Avitaminosen: Blutfermente bei experimentellem Skorbut
• The blood and blood-vessels in guinea-pig scurvy (1921)
• Recent advances in knowledge of scurvy and the antiscorbutic vitamin
• The peripheral vascular system and its reactions in scurvy: an experimental study
• A deficient binding mechanism for norepinephrine in hearts of scorbutic guinea pigs
• Intercellular substances in experimental scorbutus
• Relation of scurvy to histological changes in the pancreas
• Adrenalin in scurvy
• The pathophysiology of scurvy
• Scurvy, Megaloblastic Anaemia and Osteoporosis
• Erythropoiesis in scurvy
• Scurvy in adults, Especially the effect of food rich in vitamin C on blood formation
• Scurvy A rare disease?
• Scurvy and Hemarthrosis

Top

Shigellosis

• Single dose vitamin A treatment in acute shigellosis in Bangladesh children: randomised double blind controlled trial.
• Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation.

Top

Stroke

• Vitamin E and beta carotene supplementation in high risk for stroke: a subgroup analysis of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.
• Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study.
• Plasma vitamin C modifies the association between hypertension and risk of stroke.
• Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study.
• Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group.

Top

Tissue

• The role of ascorbic acid in the biosynthesis of collagen. II Site and nature of ascorbic acid participation
• Structural makeup of capillary wall
• Tissue changes in vitamin deficiencies
• Normal cevitamic (ascorbic) acid determinations in blood plasma and their relationship to capillary resistance
• Function of ascorbic acid in collagen metabolism
• The effect of cevitamic acid injections on capillary resistance
• The action of vitamin C on blood vessels
• Ascorbic acid-independent and ascorbic acid-dependent collagen-forming mechanisms
• Hydroxyprolinemia: III. The origin of free hydroxyproline in hydroxyprolinemia. Collagen turnover. Evidence for a biosynthetic pathway in man
• Influence of vitamin C and magnesium on calcium, magnesium and copper contents on guinea pig tissues
• The biochemical role of ascorbic acid in connective tissue

Top

Vitamin Deficiency

• The effect of vitamin C deficiency on healed wounds
• The pathologic changes resulting from vitamin deficiency
• Rice and Beri-Beri
• Observations on the heart rate in vitamin B1 and C deficiency
• The influence of metabolic factors in Beri-Beri
• Heart and circulation in a tropical avitaminosis (Beri-Beri)
• German: Vitamin B-Untersuchungen. Zur Frage des Zusammenhanges zwischen Vitamin B1 Mangel und Bradykardie
• Treatment of Human Pellagra with Nicotinic Acid
• The influence of vitamin deficiencies on susceptibility to certain poisons
• German: B-Avitaminosis und Beriberi.
• German: Herz und Kreislauf bei der Beri-beri-Krankheit
• Cerebral monoamine metabolism in guinea pigs with ascorbic acid deficiency
• Effect of vitamin deficiencies on carbohydrate metabolism
• Enzymic efficiency in avitaminosis
• Blood pyruvate in vitamin B1 deficiency
• The influence of a vitamin-free diet on the carbohydrate metabolism
• Vitamin B2 deficiencies as affected by dietary carbohydrate
• When is capillary fragility a sign of vitamin C subnutrition in man?
• German: Untersuchungen über den intermediären Kohlenhydratstoffwechsel bei Avitaminose

Top

Vitamins, Minerals and Other Micronutrients – Miscellaneous Studies

• Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort
• A review of current evidence for acetyl-l-carnitine in the treatment of depression
• Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance
• Some aspects of vitamin C metabolism
• Outline of a method for the determination of the strength of the skin capillaries and the indirect estimation of the individual vitamin C standard
• The Sheffield Experiment on the vitamin C requirement of human adults
• Ascorbic acid and the peripheral vascular system
• Formation of epithelial basement membrane is restricted by scurvy in vitro and is stimulated by vitamin C
• Pharmacologic and therapeutic properties of crystalline vitamin c (cevitamic acid)
• The regulation of prostaglandin el formation: A candidate for one of the fundamental mechanisms involved in the actions of vitamin C
• The membrane transport of ascorbic acid
• The effect of supplementary vitamin C and iron on haemopoiesis in old age
• Ascorbic acid supplementation in the treatment of pressure-sores
• A study of vitamin C levels in the aged and subsequent mortality
• Plant polyphenols as antioxidants for ascorbic acid
• The influence of ascorbic acid upon the liver
• The discovery of vitamines
• Studies on the vitamin B complex
• Improved yields of vitamin B1
• German: Über das antineuritische Vitamin
• Observations on the concentration of vitamin B1
• The nutrition of staphylococcus aureus. The activities of nicotinamide, aneurin (vitamin B1)and related compounds
• The determination of the antineuritic vitamin
• The physiological function of vitamin B1
• Interrelationship of Vitamins
• Maintenance nutrition in the pigeon. The effect of vitamin B1
• The Vitamins
• Daily vitamin C consumption and reported respiratory findings
• The clinical and biochemical effects of vitamin C supplementation in Short-stay hospitalized Geriatric Patients
• Effect of ascorbic acid and indolyl acetic acid on regeneration of Willow Branches and Germination
• Studies on L-Ascorbic Acid Metabolism in rats Under chronic taxicity due to organophosphorus insecticides: Effects of supplementation of L-Ascorbic Acid in high doses
• Prevention by ascorbic acid of liver glycogen depletion in endotoxind intoxication
• German: Vitamine-B und Darmresorption
• Aneurin (vitamin B1) and pyruvate metabolism by staphylococcus aureus
• German: Beziehungen des Vitamin-B-Komplexes (insbesondere des Vitamin B1) zum Kohlenhydrathaushalt
• Aminoacidemia of Prematurity
• The synthesis of antineuritic vitamin by Yeast (1927)
• Administration of ascorbic acid to an alkaptonuric patient
• Vitamin C Requirement of Human Adults
• The precautionary principle: a critique in the context of the EU Food Supplements Directive
• The European regulation of food supplements and food fortification
• Food supplements and European Regulation within a Precautionary Context: A Critique and Implications for Nutritional, Toxicological and Regulatory Consistency
• Food supplements and fortified foods: the EC's patriarchal precautionary perspectives on public health
• New recommended daily allowances: benchmarking healthy European micronutrient regulation

Top

Wound Healing

• Effect of ascorbic acid on oral healing in guinea pig
• Vitamin C deficiency and wound healing
• The relationship of the concentration of ascorbic acid of the blood to the tensile strength of wounds in animals
• German: Histologische untersuchungen über das verhalten des Vitamins C in den verschiedenen Organen während der Wundheilung
• Wound Healing - A New Perspective with Particular Reference to Ascorbic Acid Deficiency
• Ascorbic acid economy in surgical patients
  as indicated by blood ascorbic acid levels (1958)
• The role of vitamin C in wound healing
• Ascorbic acid and epithelial regeneration
• An experimental study in wound healing in vitamin C depleted human subjects
• The effect of vitamin C on mucopoly-saccharide production in wound healing
• Vitamin C, disease, and surgical trauma
• Vitamin C and wound healing: Ascorbic acid content and tensile strength of healing wounds in human beings
• Wound healing in rats with biotin, pyridoxin, or riboflavin deficiencies
• Vitamin C and repair of injured tissues
• Some biochemial aspects of fibrogenesis and wound healing
• Ascorbic acid treatment on early collagen production and wound healing in the guinea pig
• Effect of vitamin C deficiency on healed wounds
• Wound healing and collagen formation
• Effects of absolute and partial vitamin C deficiency on healing of wounds
• The significance of cevitamic acid deficiency in surgical patients
• Vitamin and protein factors in pre-operative and postoperative care of the
  surgical patient
• Ascorbic acid economy in surgical patients as indicated by blood ascorbic acid levels
• The effect of vitamin C on third molar surgery

Top