Pulmonary toxicity of an atmospheric particulate sample is due to the soluble fraction
- PMID: 10329506
- DOI: 10.1006/taap.1999.8658
Pulmonary toxicity of an atmospheric particulate sample is due to the soluble fraction
Abstract
Adverse health effects have been associated with the inhalation of a variety of atmospheric particles. The potential toxicity of a recently collected urban air particulate sample (EHC-93, mean diameter < 1 microm) was assessed after instilling 1 mg to mouse lung. A soluble fraction (15% of total) and an insoluble fraction of the original dust were also instilled at 1 and 0.15 mg doses and the lung reaction was followed for up to 8 weeks. The complete dust sample induced an inflammatory response in the first week with increased cell numbers and protein levels in lavage fluid. There was also ultrastructural evidence of epithelial necrosis followed by increased thymidine labeling during repair. The insoluble fraction induced only mild inflammation with no evidence of cell injury or repair at either dose. The soluble fraction produced similar early inflammatory changes but also produced the greatest lung injury. Type 1 cell necrosis was observed, followed by increased tritiated thymidine uptake mainly by Type 2 epithelial cells. This was found after 0.15 mg soluble fraction and was greatly increased in the 1.0 mg group, which subsequently developed fibrosis. The results indicate that while all particle samples induce some inflammation, the lung toxicity produced by the total dust sample EHC-93 can be accounted for by the reaction to its 15% soluble component. This suggests that the pulmonary response and cell injury following exposure to this urban dust is related to soluble material, probably metal ions, rather than to the number or composition of the insoluble particles.
Copyright 1999 Academic Press.
Similar articles
-
Zinc is the toxic factor in the lung response to an atmospheric particulate sample.Toxicol Appl Pharmacol. 2000 Jul 15;166(2):111-9. doi: 10.1006/taap.2000.8955. Toxicol Appl Pharmacol. 2000. PMID: 10896852
-
Comparative pulmonary toxicity of various soluble metals found in urban particulate dusts.Exp Lung Res. 2002 Oct-Nov;28(7):563-76. doi: 10.1080/01902140290096782. Exp Lung Res. 2002. PMID: 12396249
-
Soluble and insoluble air particle fractions induce differential production of tumor necrosis factor alpha in rat lung.Exp Lung Res. 2004 Jul-Aug;30(5):355-68. doi: 10.1080/01902140490438933. Exp Lung Res. 2004. PMID: 15204828
-
Particle characteristics responsible for effects on human lung epithelial cells.Res Rep Health Eff Inst. 2002 Dec;(110):1-65; discussion 67-76. Res Rep Health Eff Inst. 2002. PMID: 12578113 Review.
-
Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles.Inhal Toxicol. 1996;8 Suppl:73-89. Inhal Toxicol. 1996. PMID: 11542496 Review.
Cited by 17 articles
-
Toxicity of Water- and Organic-Soluble Wood Tar Fractions from Biomass Burning in Lung Epithelial Cells.Chem Res Toxicol. 2021 Jun 21;34(6):1588-1603. doi: 10.1021/acs.chemrestox.1c00020. Epub 2021 May 25. Chem Res Toxicol. 2021. PMID: 34033466 Free PMC article.
-
In vitro assessment of arsenic mobility in historical mine waste dust using simulated lung fluid.Environ Geochem Health. 2018 Jun;40(3):1037-1049. doi: 10.1007/s10653-017-9974-x. Epub 2017 May 12. Environ Geochem Health. 2018. PMID: 28497229
-
In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids.Int J Environ Res Public Health. 2017 Jan 24;14(2):112. doi: 10.3390/ijerph14020112. Int J Environ Res Public Health. 2017. PMID: 28125027 Free PMC article.
-
Combined toxic effect of airborne heavy metals on human lung cell line A549.Environ Geochem Health. 2018 Feb;40(1):271-282. doi: 10.1007/s10653-016-9901-6. Epub 2016 Nov 25. Environ Geochem Health. 2018. PMID: 27888373
-
Bioaccessibility of trace elements in fine and ultrafine atmospheric particles in an industrial environment.Environ Geochem Health. 2015 Oct;37(5):875-89. doi: 10.1007/s10653-015-9756-2. Epub 2015 Aug 9. Environ Geochem Health. 2015. PMID: 26254887
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources