'I told Oprah Winfrey to shut the f**k up': Rose Byrne reveals she had words with media mogul on-set of new TV movie

She stars alongside Oprah Winfrey in the upcoming HBO film The Immortal Life of Henrietta Lacks.

And in an interview with ET this week, Rose Byrne revealed she had words with the media mogul on-set.

The 37-year-old Bridesmaids star told the famed talk show host to 'shut the f**k up.'

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'I told Oprah Winfrey to shut the f**k up': Rose Byrne, 37, revealed to ET that she had words with the media mogul on-set of HBO film The Immortal Life of Henrietta Lacks

'I told Oprah Winfrey to shut the f**k up': Rose Byrne, 37, revealed to ET that she had words with the media mogul on-set of HBO film The Immortal Life of Henrietta Lacks

Flirt with florals in a maxi dress like Rose Byrne

Rose Byrne has been busy promoting her latest TV project, The Immortal Life of of Henrietta Lacks and she's doing it in style.

She was spotted outside CBS studios wearing a prairie inspired multi-patterned frock by Coach and during another press event, she donned this floral print stunner by Rosie Assoulin.

The strapless number featured tiers of ruffled fabric and a colorful yet subtle efflorescent design. Rose teamed it with a pair of purple pointy toe pumps and a box clutch to complete the look.

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Rose was required to yell obscenities at Oprah's character in the telemovie.

'It was intense! It was a long day, but we wanted to do a good job and we were g-ed up to do it,' the actress told Entertainment Tonight.

'It was one of those strange surreal moments in your life but that's acting you know?' 

Just for the role: Rose was required to yell obscenities at Oprah Winfrey's character in the telemovie: 'It was intense!' the actress told Entertainment Tonight

Just for the role: Rose was required to yell obscenities at Oprah Winfrey's character in the telemovie: 'It was intense!' the actress told Entertainment Tonight

Gushing: Rose also praised her co-star who admitted to being 'nervous' prior to acting out the scenes: 'She's incredibly humble for someone of her, being a living legend really'

Gushing: Rose also praised her co-star who admitted to being 'nervous' prior to acting out the scenes: 'She's incredibly humble for someone of her, being a living legend really'

Rose also praised her co-star who admitted to being 'nervous' prior to acting out the scenes.

'She's incredibly humble for someone of her, being a living legend really,' she gushed. 

The film, based on the book of the same name, details the life of Henrietta Lacks.

Taking the lead: Renée Elise Goldsberry (far left) takes on the title role of Henrietta Lacks

Taking the lead: Renée Elise Goldsberry (far left) takes on the title role of Henrietta Lacks

Henrietta's cervical cancer cells were immortalised into the HeLa cell line, which became crucial to medical research.

Renée Elise Goldsberry takes on the title role, while Rose plays Rebecca Skloot, author of the #1 New York Times bestseller on which the HBO film is based.

Oprah, who has helped executive produce, also stars in the drama as Henrietta's daughter Deborah Lacks. 

Every angle: Oprah, who has helped executive produce, also stars in the drama as Henrietta's daughter Deborah Lacks

Every angle: Oprah, who has helped executive produce, also stars in the drama as Henrietta's daughter Deborah Lacks

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