Seth Rogen and wife Lauren Miller host sixth annual Hilarity For Charity variety show to fight Alzheimer’s

There's nothing funny about Alzheimer’s.

But Seth Rogen turned to comedy once again on Saturday night to help in the battle against the debilitating disease.

The 35-year-old hosted his annual Hilarity For Charity variety show at the Hollywood Palladium in Los Angeles.

Seth Rogen and wife his Lauren Miller hosted their sixth annual Hilarity For Charity variety show to fight Alzheimer’s on Saturday night

Seth Rogen and wife his Lauren Miller hosted their sixth annual Hilarity For Charity variety show to fight Alzheimer’s on Saturday night

The actor arrived with his gorgeous wife Lauren Miller, who stunned in a bright yellow gown with black lace flower detailing.

While Saturday's gig was the sixth time it was held, it was also the first to be streamed on Netflix.

Special guests on the night included Ike Barinholtz, Alison Brie, Michael Che, Sacha Baron Cohen, James Corden, Tiffany Haddish, Nick Kroll, John Mulaney, Kumail Nanjiani, Craig Robinson, Sarah Silverman, and Michelle Wolf.

There were also performances by Post Malone and The Muppets.

Fab: The actor arrived with his gorgeous wife Lauren Miller, who stunned in a bright yellow gown with black lace flower detailing

Fab: The actor arrived with his gorgeous wife Lauren Miller, who stunned in a bright yellow gown with black lace flower detailing

Support: Sarah Silverman hit the red carpet in fishnet tights, denim shorts and below the knee boots, wrapping up in a yellow cardigan

Support: Sarah Silverman hit the red carpet in fishnet tights, denim shorts and below the knee boots, wrapping up in a yellow cardigan

Messsers: She arrived with her pal, who drew attention in a multi-pastel-colored dress

Messsers: She arrived with her pal, who drew attention in a multi-pastel-colored dress

Do ya, punk? Scott Eastwood has mastered his dad Clint's disgusted/puzzled stare

Do ya, punk? Scott Eastwood has mastered his dad Clint's disgusted/puzzled stare

Silverman hit the red carpet in fishnet tights, denim shorts and below the knee boots, wrapping up in a yellow cardigan. 

She arrived with her pal, who drew attention in a multi-pastel-colored dress.

Kaley Cuoco put on an eye-popping display in a very low-cut black dress, as she arrived with fiance Karl Cook.

Scott Eastwood, Jon Lovitz and Stranger Things star James Landry Hebert.

Wow: Kaley Cuoco put on an eye-popping display in a very low-cut black dress

Wow: Kaley Cuoco put on an eye-popping display in a very low-cut black dress

Betrothed: She arrived with fiance Karl Cook

Betrothed: She arrived with fiance Karl Cook

Pal: Seth's Neighbors co-star Ike Barinholtz was on hand

Pal: Seth's Neighbors co-star Ike Barinholtz was on hand

Another late night: Nick Kroll was in the house
Another late night: James Corden was among the special guests

Another late night: Nick Kroll and James Corden were also in the house

Partner: Rogen's frequent collaborator Craig Robinson was also on the guest list

Partner: Rogen's frequent collaborator Craig Robinson was also on the guest list

'We started the Los Angeles variety show six years ago in order to raise awareness for Alzheimer’s, a disease that has touched so many families including my own,' Miller Rogen said before the show.

'Our goal is to educate a younger audience and ultimately create the next generation of advocates for the cause. I am so thrilled to be able to share this year’s show with an even larger audience through our partnership with Netflix and are proud to have them as a partner.'

Since its inception in 2012, Hilarity For Charity has raised for than $7million to help families struggling with Alzheimer’s care, increase support groups nationwide, and fund cutting edge research.

DJ Caroline D'Amore
Actress Ashley Jones
Actress Katrina Begin

Guest list: (L-R) DJ Caroline D'Amore, Ashley Jones and Katrina Begin caught the show

Howling with laughter: The charity's long-time supporter Michelle Wolf was there

Howling with laughter: The charity's long-time supporter Michelle Wolf was there

En route: Stranger Things star James Landry Hebert was spotted on the blue carpet
En route: Comedy legend Jon Lovitzwas spotted on the blue carpet

En route: Stranger Things star James Landry Hebert and comedy legend Jon Lovitz were both spotted on the blue carpet

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