NESS-040C5

NESS-040C5
Clinical data
ATC code	none;
Legal status
Legal status	CA: Schedule II;
Identifiers
	IUPAC name N-(2-isopropyl-5-methylcyclohexyl)-1-(4-methylbenzyl)-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide;
CAS Number	1445751-90-5;
Chemical and physical data
Formula	C27H33N3OS
Molar mass	447.64 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC(C=C1)=CC=C1CN2C3=C(CC4=C3SC=C4)C(C(NC5CC(C)CCC5C(C)C)=O)=N2 ;

NESS-040C5 is a potent cannabinoid agonist which was developed for the treatment of glaucoma.^[1] It has reasonable selectivity for the CB₂ receptor subtype, having a CB₂ affinity of 0.4nM, and 25x selectivity over the related CB₁ receptor.^[2]

References[edit]

^ Paolo Lazzari et al. Pharmaceutical Compounds. US Patent 8106218
^ Hanus LO, Mechoulam R. Novel natural and synthetic ligands of the endocannabinoid system. Current Medicinal Chemistry. 2010;17(14):1341-59. PMID 20166928

This cannabinoid related article is a stub. You can help Wikipedia by expanding it.

[1] Paolo Lazzari et al. Pharmaceutical Compounds. US Patent 8106218

[2] Hanus LO, Mechoulam R. Novel natural and synthetic ligands of the endocannabinoid system. Current Medicinal Chemistry. 2010;17(14):1341-59. PMID 20166928

[1]

[2]

NESS-040C5

See also[edit]

References[edit]

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Clinical data

ATC code	none
Legal status
Legal status	CA: Schedule II
Identifiers
IUPAC name N-(2-isopropyl-5-methylcyclohexyl)-1-(4-methylbenzyl)-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide
CAS Number	1445751-90-5
Chemical and physical data
Formula	C₂₇H₃₃N₃OS
Molar mass	447.64 g/mol
3D model (JSmol)	Interactive image
SMILES CC(C=C1)=CC=C1CN2C3=C(CC4=C3SC=C4)C(C(NC5CC(C)CCC5C(C)C)=O)=N2