Elizabeth Perkins, 57, from the movie Big reveals she has been battling Type 1 diabetes for 13 years and at one point it made her gain 40lbs
She's best known for her Eighties movie roles in Big with Tom Hanks and About Last Night with Demi Moore - and, more recently - the TV series Weeds.
But it hasn't all been easy for actress Elizabeth Perkins, 57, who revealed on Wednesday she has been struggling with type 1 diabetes.
The New York native told People that she initially thought she had mononucleosis and was shocked to learn she had diabetes after visiting a doctor in 2005. And the screen siren added that it was very hard gaining the 40lbs that has come with the drugs she takes for the disease.
Auto-immune disease: Elizabeth Perkins reveals she gained 40lbs and 'puffed up like a basketball' after diabetes diagnosis in 2005; pictured in March 2018
A smash hit: The beauty is best known for co-starring with Tom Hanks in the 1988 movie Big
Having just finished wrapping up the first season of Weeds, Elizabeth confessed she had gone in for a routine blood test following symptoms of excessive thirst and weight loss - before being immediately rushed to the hospital.
'The doctor told me my blood sugar was 640. Normal is 100. Boom. I had diabetes,' she said.
Diabetes in an auto-immune disorder in which the immune system attacks cells in the pancreas that makes insulin.
Struggle: 'I just puffed up like a basketball. I was on Weeds, and everyone saw me get bigger and bigger. It's been challenging as hell,' she said; seen on the set of Weeds with Mary-Louise Parker
Her changing figure: The looker at her thinnest in 2001, left, and in 2007, right, after she had to take medication for her disease
Having to inject herself with insulin four to six times a day, Elizabeth revealed she struggled with the immediate 40 pound weight gain.
'You're injecting a hormone that stores fat,' she explained.
'I just puffed up like a basketball. I was on Weeds, and everyone saw me get bigger and bigger. It's been challenging as hell.'
A memorbale movie: Perkins played the angry best friend opposite Demi Moore in About Last Night in 1986 which also starred Rob Lowe and James Belushi
Another hit: And in 1994 the star was in The Flintstones with Rick Moranis, Rosie O'Donnell, and John Goodman
With only five to 10 percent of diabetics diagnosed with type 1 and no current way to cure the disease, Elizabeth has had to manage it herself for the past 13 years.
But things haven't stopped the beauty - who plays Mandy Moore's mom in This Is Us - from having a thriving home life.
Recently an empty nester, the mom-of-four added she was having 'more sex now than ever!' with her husband of 18-years Julio Macat, 60.
Other celebrities who suffer from the disease are Halle Berry, Nick Jonas and Mary Tyler Moore, have also openly spoken about their diagnosis.
Living her best life! Recently an empty nester, the mom-of-four added she was having 'more sex now than ever!' with her husband of 18-years Julio Macat, 60