The Frontal Lobes and Neuropsychiatric Illness (2001) by Drs Stephen P. Salloway, Paul F. Malloy, and James D. Duffy (editors) provides an excellent summation on the state of knowledge of prefrontal lobe dysfunction in neuropsychiatry. It is written in four parts. Part 1 is Introduction; Part 2, “Functional Organization of Prefrontal Lobe Systems” consists of 5 chapters; Part 3, “Prefrontal Syndromes in Clinical Practice” consists of 4 chapters; and Part 4, “Frontal Lobe Dysfunction in Neuropsychiatric Disorders” is composed of 5 chapters — 16 chapters and 264 pages in all.

Author: Eric R. Kandel

Published by: W.W. Norton & Co., New York, NY, USA
Price: $19.95

A unifying principle of American law governing the defensive use of deadly force is that a victim may use such force when an attacker threatens violence capable of causing death or grave bodily harm. There is little doubt that it is justified when the robber draws and points a handgun at the victim.

The act of self-defense can have a double effect: the preservation of one's life;
and the killing of the aggressor...The one is intended, the other is not.
— Saint Thomas Aquinas

The material compiled in this slim but compact tome, The Neuropsychiatry of Limbic and Subcortical Disorders, was originally published in the Journal of Neuropsychiatry and Clinical Neuroscience in 1997. It was expanded and republished in book form made possible by a grant from Hoechst Marion Roussel Pharmaceuticals.

We must be careful not to rush to label glyphosate as excessively toxic to humans because when used properly and in proper quantities it is probably no more dangerous and toxic than other effective herbicides on the market. Unfortunately, most effective herbicides and insecticides could be classified as neurotoxic and carcinogenic because in high enough concentrations they can be toxic to biological systems.

Abstract — The search for longevity, if not for immortality itself, has been as old as recorded history. The great strides made in the standard of living and the advances in scientific medicine, have resulted in unprecedented increases in longevity, concomitant with improved quality of life.

Abstract — In 2013, U.S. President Barack Obama decreed the creation of the Presidential Commission for the Study of Bioethical Issues, as part of his $100 million Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative. In the wake of the work of this Commission, the purpose, goals, possible shortcomings, and even dangers are discussed, and the possible impact it may have upon neuroscience ethics (Neuroethics) both in clinical practice as well as scientific research.

This interview resulted in the May 14, 2014 article, "U.S. Experts urge focus on ethics in brain research" by Kerry Sheridan, AFP Correspondent. The article was distributed through the NewsCred Smartwire, Agence France Presse.

Kerry Sheridan, Agence France-Presse (AFP): Hi Dr. Faria, I'm working on a story about calls for consideration of ethics in neuroscience research, and I was wondering if I could interview you about your thoughts on the need for ethical oversight in neuroscience?

CURRICULUM VITAE

MIGUEL A. FARIA, JR., M.D.

BORN: September 30, 1952 in Sancti Spiritus, Cuba
U.S. CITIZEN: 1971
FLUENT IN LANGUAGES OTHER THAN ENGLISH: Spanish

EDUCATION:

* Eau Claire High School, Columbia, South Carolina (1970; National Honor Society)

* University of South Carolina, Columbia, South Carolina (1970-1973). Bachelor of
   Science (B.S.) degree in Biology with a minor in Psychology (1973; graduated
   Magna Cum Laude)

In his three-part series on psychosurgery in America entitled "Violence, Mental Illness and the Brain," my friend, Dr. Miguel Faria, has written one of the best published summaries on the history of neurosurgical treatment of psychiatric disorders by selective sectioning or abolition of specific parts of the behavioral brain.

Abstract — In the final installment to this three-part, essay-editorial on psychosurgery, we relate the history of deep brain stimulation (DBS) in humans and glimpse the phenomenal body of work conducted by Dr. Jose Delgado at Yale University from the 1950s to the 1970s.

Abstract — Knowledge of neuroscience flourished during and in the wake of the era of frontal lobotomy, as a byproduct of psychosurgery in the late 1930s and 1940s, revealing fascinating neural pathways and neurophysiologic mechanisms of the limbic system for the formulation of emotions, memory, and human behavior. The creation of the Klüver‑Bucy syndrome in monkeys opened new horizons in the pursuit of knowledge in human behavior and neuropathology.

Abstract — Psychosurgery was developed early in human prehistory (trephination) as a need perhaps to alter aberrant behavior and treat mental illness. The “American Crowbar Case" provided an impetus to study the brain and human behavior. The frontal lobe syndrome was avidly studied. Frontal lobotomy was developed in the 1930s for the treatment of mental illness and to solve the pressing problem of overcrowding in mental institutions in an era when no other forms of effective treatment were available. Lobotomy popularized by Dr.

There are a growing number of clinicians and basic scientists who are convinced that a group of compounds called excitotoxins play a critical role in the development of several neurological disorders including migraines, seizures, infections, abnormal neural development, certain endocrine disorders, neuropsychiatric disorders, learning disorders in children, AIDS dementia, episodic violence, lyme borreliosis, hepatic encephalopathy, specific types of obesity, and especially the neurodegenerative diseases, such as ALS, Parkinson's disease, Alzheimer's disease, Huntington's disease, and olivo

ABSTRACT Tacrine (1,2,3,4-tetrahydro-5-aminoacridine, THA, Cognex®) has had an interesting history since its synthesis in Australia as part of the WWII effort. In 1986, it was described in its oral form as a potential treatment for Alzheimer's disease. In 1993, it became the first FDA approved treatment for Alzheimer's, but this was not without controversy, and many practitioners believed the drug was ineffective and hepatotoxic.

Neurosurgeon George Chovanes, M.D., begins his writing career with an ambitious project involving science, neurosurgery, politics and mystery. The protagonist in The Sharp Edge of the Soul is chief neurosurgical resident, Dr. Alex Adams, who is suspect of the chief of neurosurgery, Dr. Victor Todd. Todd makes philosophical comments about the perennial neurosurgeon's preoccupation with the mind-brain dilemma --- he wishes to program the mind by altering the brain. Dr. Todd is researching this with monkeys. But is he also using humans?

In Part I, we discussed in general terms some of the shortcomings I encountered in many of the grant proposals submitted during my stint as a grant reviewer for the Centers for Disease Control and Prevention's National Center for Injury Prevention and Control (NCIPC) in the years 2002-2004 [6]. There is no reason to believe that these epidemiologic and scientific shortcomings have been addressed and corrected in subsequent years.

During the years 2002-2004, I served in the Injury Research Grant Review Committee (IRGRC, more recently the "Initial Review Group") of the Centers for Disease Control and Prevention (CDC) - more specifically, the National Center for Injury Prevention and Control (NCIPC).