The Wayback Machine - https://web.archive.org/all/20050307005843/http://www.med.unc.edu:80/wrkunits/3ctrpgm/alcohol/faculty/OverstreetDH/DHO.htm

David Overstreet, Ph.D.

David H. Overstreet, Ph.D.

Professor

Bowles Center for Alcohol Studies
& Department of Psychiatry

Director, Animal Core
Department of Psychiatry

Office | 3009A Thurston-Bowles Bldg, CB# 7178

Email | dhover@med.unc.edu


Research Interests

See the Psychogenetics Webpage

 

Center Line Articles


Selected Publications

Click here for a list of publications from PubMed

Dremencov E, Newman ME, Kinor N, Blatman-Jan G, Schindler CJ, Overstreet DH, Yadid G. Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment. Neuropharmacology. 2005 Jan;48(1):34-42.

Breese GR, Overstreet DH, Knapp DJ. Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis. Psychopharmacology (Berl). 2004 Oct 23; [Epub ahead of print]

Overstreet DH, Griebel G. Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression. Eur J Pharmacol. 2004 Aug 16;497(1):49-53.

Overstreet DH, Knapp DJ, Breese GR. Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol. Pharmacol Biochem Behav. 2004 Jul;78(3):459-64.

Knapp DJ, Overstreet DH, Moy SS, Breese GR. SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats. Alcohol. 2004 Feb;32(2):101-11.

Overstreet DH, Knapp DJ, Breese GR. Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors. Pharmacol Biochem Behav. 2004 Feb;77(2):405-13.

Janowsky DS, Davis JM, Overstreet DH. Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary study. Pharmacol Biochem Behav. 2004 Feb;77(2):337-43.

Hensler JG, Hodge CW, Overstreet DH. Reduced 5-HT3 receptor binding and lower baseline plus maze anxiety in the alcohol-preferring inbred fawn-hooded rat. Pharmacol Biochem Behav. 2004 Feb;77(2):281-9.

Dremencov E, Gispan-Herman I, Rosenstein M, Mendelman A, Overstreet DH, Zohar J, Yadid G. The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):141-7.

Breese GR, Knapp DJ, Overstreet DH. Stress sensitization of ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonist. Neuropsychopharmacology. 2004 Mar;29(3):470-82.

Breese GR, Knapp DJ, Overstreet DH. Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT(1A)-Receptor Agonist. Neuropsychopharmacology. 2003 Sep 3 [Epub ahead of print]

Overstreet DH, Kralic JE, Morrow AL, Ma ZZ, Zhang YW, Lee DY. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT(2C) agonists. Pharmacol Biochem Behav. 2003 Jun;75(3):619-25.

Rezvani AH, Overstreet DH, Perfumi M, Massi M. Plant derivatives in the treatment of alcohol dependency. Pharmacol Biochem Behav. 2003 Jun;75(3):593-606.

Overstreet DH, Commissaris RC, De La Garza R, File SE, Knapp DJ, Seiden LS. Involvement of 5-HT1A Receptors in Animal Tests of Anxiety and Depression: Evidence from Genetic Models. Stress. 2003 Jun;6(2):101-10.

Overstreet DH, Knapp DJ, Moy SS, Breese GR. A 5-HT(1A) agonist and a 5-HT(2c) antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats. Psychopharmacology. 2003 Jun;167(4):344-52.

Yu B, Liu J, Overstreet DH, Gallagher JP. Serotonin produces an enhanced outward current recorded at rat dorsal lateral septal neurons from the Flinders Sensitive Line of rats, a genetically-selected animal model of depression. Neurosci Lett. 2003 Mar 27;339(3):235-8.

Overstreet DH, Keung WM, Rezvani AH, Massi And M, Lee DY. Herbal remedies for alcoholism: promises and possible pitfalls. Alcohol Clin Exp Res. 2003 Feb;27(2):177-85.

Overstreet DH, Daws LC, Yadid G, Friedman E, Mathe AA, Janowsky DS. Comment on "preclinical models: status of basic research in depression". Biol Psychiatry. 2003 Feb 1;53(3):268-70.

Gonzalez LE, Parada MA, Tucci S, Teneud L, Overstreet DH, Hernandez L. A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function. Braz J Med Biol Res. 2003 Feb;36(2):263-7.

Overstreet DH. Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists. Behav Genet. 2002 Sep;32(5):335-48.

Overstreet DH, Knapp DJ, Breese GR. Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawals. Alcohol Clin Exp Res. 2002 Aug;26(8):1259-68.

Keyler DE, Baker JI, Lee DY, Overstreet DH, Boucher TA, Lenz SK. Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028. J Altern Complement Med. 2002 Apr;8(2):175-83.


Back to Top

 
Bowles Center for Alcohol Studies
University of North Carolina at Chapel Hill
CB#7178, Thurston Bowles Building
Chapel Hill, NC 27599-7178
Tel: (919) 966-5678 • Fax: (919) 966-5679

Updated 01/04/2005  
contact: webmaster 
UNC Home Page 
UNC School of Medicine