Research
Interests
My research
interests concern the cellular and molecular mechanisms underlying
hypoxic and toxic injury to liver and heart cells and organs stored
for transplantation surgery. In particular, my laboratory is applying
new techniques of laser scanning confocal microscopy to characterize
the physiology of single living cells, including the assessment
of ion homeostasis, mitochondrial function, electrical potentials,
volume regulation, membrane permeability and other biochemical
parameters during the pathogenesis of lethal cell injury.
Other Resources
Dr.
Lemasters @ UNC Department of Cell and Developmental Biology
Center
Line Articles
Selected
Publications
Click
here for a list of publications from PubMed
Kon
K, Kim JS, Jaeschke H, Lemasters JJ. Mitochondrial
permeability transition in acetaminophen-induced necrosis and
apoptosis of cultured mouse hepatocytes. Hepatology. 2004
Nov;40(5):1170-9.
Black
D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters
JJ, Brenner DA, Rippe RA, Behrns KE. Primary
cirrhotic hepatocytes resist TGFbeta-induced apoptosis through
a ROS-dependent mechanism. J Hepatol. 2004 Jun;40(6):942-51.
Zhong
Z, Connor HD, Froh M, Lind H, Bunzendahl H, Mason RP, Thurman
RG, Lemasters JJ. Polyphenols
from Camellia sinenesis prevent primary graft failure after transplantation
of ethanol-induced fatty livers from rats. Free Radic Biol
Med. 2004 May 15;36(10):1248-58.
Lemasters
JJ. Rusty
notions of cell injury. J Hepatol. 2004 Apr;40(4):696-8.
Schwabe
RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA.
Differential
requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated
apoptosis in hepatocytes. FASEB J. 2004 Apr;18(6):720-2. Epub
2004 Feb 06.
Bataller
R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T,
Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. NADPH
oxidase signal transduces angiotensin II in hepatic stellate cells
and is critical in hepatic fibrosis. J Clin Invest.
2003 Nov;112(9):1383-94.
Kim
JS, He L, Qian T, Lemasters JJ. Role
of the mitochondrial permeability transition in apoptotic and
necrotic death after ischemia/reperfusion injury to hepatocytes.
Curr Mol Med. 2003 Sep;3(6):527-35. Review.
Kim
JS, He L, Lemasters JJ. Mitochondrial
permeability transition: a common pathway to necrosis and apoptosis.
Biochem Biophys Res Commun. 2003 May 9;304(3):463-70.
Oh
KW, Qian T, Brenner DA, Lemasters JJ. Salicylate
enhances necrosis and apoptosis mediated by the mitochondrial
permeability transition. Toxicol Sci. 2003 May;73(1):44-52.
Kelly
D, Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul
H, Bradford B, Lemasters JJ. L-Glycine: a novel antiinflammatory,
immunomodulatory, and cytoprotective agent. Curr Opin Clin
Nutr Metab Care. 2003 Mar;6(2):229-40.
Kim JS, Qian T, Lemasters JJ. Mitochondrial
permeability transition in the switch from necrotic to apoptotic
cell death in ischemic rat hepatocytes.Gastroenterology. 2003
Feb;124(2):494-503.
Zhong
Z, Froh M, Connor HD, Li X, Conzelmann LO, Mason RP, Lemasters
JJ, Thurman RG. Prevention
of hepatic ischemia-reperfusion injury by green tea extract.
Am J Physiol Gastrointest Liver Physiol. 2002 Oct;283(4):G957-64.
Jaeschke
H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ
(2002) Mechanisms
of hepatotoxicity. Toxicol Sci 65:166-176.
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