Brenner’s remarkable national career began with his debut on the “The Tonight Show,” where he set the record for the most appearances of any guest on the show (158). In The Book of Lists, Brenner is noted as being the most frequent guest host of any entertainer in television’s history. Today, Brenner is a regular on David Letterman and with his insightful and topical humor, he has become a frequent guest on “Hardball with Chris Matthews” and “The O’Reilly Factor.”