Printer Friendly | Email Article | Reprints | RSS

(Page 1 of 2)

Top News Ruling Shi'ites demand Iraq regain security control Hamas urges talks on "just peace" in Mideast US and British hostages freed in Nigeria MORE

BOSTON (Reuters) - Levels of the amino acid homocysteine may be high in people destined for a heart attack or stroke, but lowering them with B vitamins and folic acid does not reduce the risk, two studies show.

"Clearly, folic acid, vitamin B12, and vitamin B6 are not the therapeutic solution expected," said Joseph Loscalzo of Brigham and Women's Hospital in Boston, in an editorial in The New England Journal of Medicine, where the results will appear.

They were reported on Sunday at the annual meeting of the American College of Cardiology in Atlanta.

In the first study, Eva Lonn of McMaster University in Ontario and her colleagues gave 5,522 volunteers from 13 countries either a placebo or supplements of vitamin B6, B12 and folic acid.

In the group that received the supplements, homocysteine

levels declined. But the likelihood of stroke, heart attack, or death from any heart-related cause did not.

The rate of heart problems or stroke was 18.8 percent for volunteers getting the supplements and 19.8 percent for the placebo recipients.

Even when they thought they might be seeing some benefit from folic acid or B vitamins, that was offset by an increased risk of another health problem, the Lonn team found.

The risk of stroke seem to fall by 25 percent for supplement recipients, but 24 percent more ended up being hospitalized for unstable angina, which can quickly lead to a heart attack. Both findings, the researchers cautioned, may have been due to chance.

While the Lonn study looked at people over 54 with diabetes or who were at risk of heart disease, the second smaller trial examined 3,749 Norwegians who started taking supplements or a placebo within seven days after surviving a heart attack.

That team, led by Kaare Bonaa of the University of Tromso, also found no clear benefit after about three years of treatment.    Continued ...

1 | 2   Next

More Health US scientists make pigs with heart-healthy fats US, African scientists seek biotech answer to hunger UK breast cancer sufferer appeals in Herceptin case Three sick Cambodians test negative for bird flu Aspirin equally heart-protective in men and women MORE