Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions

doi:10.3389/fphar.2019.01421

Review

. 2019 Nov 26;10:1421.

doi: 10.3389/fphar.2019.01421. eCollection 2019.

Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions

Emiel Jacob Henri Bartels¹, Douwe Dekker², Mohamed Amiche³

Affiliations

¹ University Medical Center, University Utrecht, Utrecht, Netherlands.
² Dutch Poisons Information Center, University Medical Center Utrecht, Utrecht, Netherlands.
³ Mondor Institute of Biomedical Research, INSERM U955 Team 7, School of Medicine, University Paris Est Créteil, Créteil, France.

PMID: 31849670
PMCID: PMC6901996
DOI: 10.3389/fphar.2019.01421

Free PMC article

Review

Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions

Emiel Jacob Henri Bartels et al. Front Pharmacol. 2019.

Free PMC article

. 2019 Nov 26;10:1421.

doi: 10.3389/fphar.2019.01421. eCollection 2019.

Authors

Emiel Jacob Henri Bartels¹, Douwe Dekker², Mohamed Amiche³

Affiliations

¹ University Medical Center, University Utrecht, Utrecht, Netherlands.
² Dutch Poisons Information Center, University Medical Center Utrecht, Utrecht, Netherlands.
³ Mondor Institute of Biomedical Research, INSERM U955 Team 7, School of Medicine, University Paris Est Créteil, Créteil, France.

PMID: 31849670
PMCID: PMC6901996
DOI: 10.3389/fphar.2019.01421

Abstract

Dermaseptins are a group of α-helical shaped polycationic peptides isolated from the Hylid frogs, with antimicrobial effects against bacteria, parasites, protozoa, viruses in vitro. Besides, anti-tumor effects have been demonstrated. However, few animal experiments and no clinical trials have been conducted thus far. This review summarizes the current knowledge on the pharmacology, ethno pharmacology, effectivity against infectious pathogens and tumors cells and the mechanism of action of the Dermaseptins. Future research should focus on further clarification of the mechanisms of action, the effectivity of Dermaseptins against several cancer cell lines and their applicability in humans.

Keywords: Phyllomedusa bicolor; amphibian; antimicrobial; dermaseptin; infectious; peptide; tumor.

Figures

**Figure 1**
Amino acid sequence alignment of 57 DRS peptides (http://aps.unmc.edu/AP/main.php) using CLUSTAL O (1.2.4) multiple sequence alignment (www.ebi.ac.uk/Tools/msa/clustalo/). The letters represent an amino acid according to conventional nomenclature. The dashes are introduced to optimize amino-acids alignments. Blue colors indicate a well-preserved amino acid (>55% of identity), green colors indicate higher rates of preservation within this DRS group (>80% of identity).

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References

1. Alves R. R., Alves H. N. (2011). The faunal drugstore: animal-based remedies used in traditional medicines in Latin America. J. Ethnobiol. Ethnomed. 7, 9. 10.1186/1746-4269-7-9 - DOI - PMC - PubMed
1. Amiche M., Galanth C. (2011). Dermaseptins as Models for the Elucidation of Membrane-Acting Helical Amphipathic Antimicrobial Peptides. Curr. Pharmaceutical. Biotechnol. 12, 1184–1193. 10.2174/138920111796117319 - DOI - PubMed
1. Amiche M., Ducancel F., Mor A., Boulain J. C., Menez A., Nicolas P. (1994). Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins. J. Biol. Chem. 269 (27), 17847–17852. - PubMed
1. Amiche M., Ladram A., Nicolas P. (2008). A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. Peptides 29 (11), 2074–2082. 10.1016/j.peptides.2008.06.017 - DOI - PubMed
1. Ammar B., Perianin A., Mor A., Sarfati G., Tissot M., Nicolas P., et al. (1998). Dermaseptin, a peptide antibiotic, stimulates microbicidal activities of polymorphonuclear leukocytes. Biochem. Biophys. Res. Commun. 247 (3), 870–875. 10.1006/bbrc.1998.8879 - DOI - PubMed

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[1] Alves R. R., Alves H. N. (2011). The faunal drugstore: animal-based remedies used in traditional medicines in Latin America. J. Ethnobiol. Ethnomed. 7, 9. 10.1186/1746-4269-7-9 - DOI - PMC - PubMed

[2] Alves R. R., Alves H. N. (2011). The faunal drugstore: animal-based remedies used in traditional medicines in Latin America. J. Ethnobiol. Ethnomed. 7, 9. 10.1186/1746-4269-7-9 - DOI - PMC - PubMed

[3] Amiche M., Galanth C. (2011). Dermaseptins as Models for the Elucidation of Membrane-Acting Helical Amphipathic Antimicrobial Peptides. Curr. Pharmaceutical. Biotechnol. 12, 1184–1193. 10.2174/138920111796117319 - DOI - PubMed

[4] Amiche M., Galanth C. (2011). Dermaseptins as Models for the Elucidation of Membrane-Acting Helical Amphipathic Antimicrobial Peptides. Curr. Pharmaceutical. Biotechnol. 12, 1184–1193. 10.2174/138920111796117319 - DOI - PubMed

[5] Amiche M., Ducancel F., Mor A., Boulain J. C., Menez A., Nicolas P. (1994). Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins. J. Biol. Chem. 269 (27), 17847–17852. - PubMed

[6] Amiche M., Ducancel F., Mor A., Boulain J. C., Menez A., Nicolas P. (1994). Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins. J. Biol. Chem. 269 (27), 17847–17852. - PubMed

[7] Amiche M., Ladram A., Nicolas P. (2008). A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. Peptides 29 (11), 2074–2082. 10.1016/j.peptides.2008.06.017 - DOI - PubMed

[8] Amiche M., Ladram A., Nicolas P. (2008). A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. Peptides 29 (11), 2074–2082. 10.1016/j.peptides.2008.06.017 - DOI - PubMed

[9] Ammar B., Perianin A., Mor A., Sarfati G., Tissot M., Nicolas P., et al. (1998). Dermaseptin, a peptide antibiotic, stimulates microbicidal activities of polymorphonuclear leukocytes. Biochem. Biophys. Res. Commun. 247 (3), 870–875. 10.1006/bbrc.1998.8879 - DOI - PubMed

[10] Ammar B., Perianin A., Mor A., Sarfati G., Tissot M., Nicolas P., et al. (1998). Dermaseptin, a peptide antibiotic, stimulates microbicidal activities of polymorphonuclear leukocytes. Biochem. Biophys. Res. Commun. 247 (3), 870–875. 10.1006/bbrc.1998.8879 - DOI - PubMed

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Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions

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Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions

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