A utopian model railroad world gone completely haywire. Featuring: a cranky but lovable engineer, his incompetent sidekick, an introspective marble statue and the occasional bat wielding killer bee. Daily, Monday through Friday.
http://www.toytrunkrailroad.com/

Bitten by a radioactive spider, college comic strip PVP gained the proportionate strength and agility of the mighty arachnid. The strip's apathy ultimately lead to the death of its beloved Uncle Ben. PvP, its entire world shattered, now appears daily; having learned the hard way that with great power, comes great responsibility. THWIP!
http://www.pvponline.com/

The story of a bon vivant couch potato, a reluctant yuppie, and a promiscuous geekette. Can they survive life with nothing but television, computers, sex and money to help them? Daily, Monday through Friday.
http://www.waitingforbob.com/

The slightly demented oddball happening of Professor Ashfield. From alternate dimensions and bad puns to cannibalism and educational looks at the Civil War. This comic is daily, Monday through Thursday, with an animated strip on Fridays.
http://www.AshfieldOnline.com

"Helen, Sweetheart of the Internet" is a strip about the glamour of the information age. The title character is a beautiful and brilliant computer geek named Helen Nichols, who at 24 runs the information systems department of a large company. Helen, her friends and co-workers inhabit an intense world where humor is as necessary as a good LAN.
http://www.peterzale.com/helen/

Bobbins: Four friends in their twenties solving everyday problems in a totally brain-wrong fashion. Enjoy soap opera, comedy and space-age thrills. It's daily.
http://www.bobbins.org/

A Dust Puppy. A mischievous A.I. An array of techies. A gaggle of non-techs. Throw them all into the offices of Columbia Internet, the hardest working, friendliest and most neurotic Internet Service Provider in the world and you have the makings of User Friendly, a chronicle of a group of well-meaning but seriously misguided Internet workers. Seven days a week.
http://www.userfriendly.org/static/

What do you get when you combine an idiotic, ALF-obsessed web site designer, a talking blue board who's mastered time travel, and a scheming teen idol who was once a member of the secretly-omnipotent pop group Hanson? You get hilarity, of course! But you also get SUPEROSITY. And hilarity! Daily, seven days a week.
http://www.superosity.com/

The adventures of an inept superhero who does battle with even more inept supervillains and tries to pick up chicks. Watch as he saves us all from the world-shattering threats of the Flying Squirrel, the Monsters of Socialism, and El-Vis. Monday through Saturday.
http://www.wfcomics.com/beetle/

A comic strip chronicling the adventures of two hapless antisocialites, their amorous pet goat, an evil yet clueless chicken, and an assorted cast of eggplants, computer programmers, sadistic bartenders, manic aliens, and Frank Coffee. Daily, Monday through Friday.
http://www.goats.com/

2 girls: a local TV news anchor and a career college student. 2 boys: a bum and a defense contractor. Think Laverne and Shirley in the year 2041. Now think of something completely different. Updated daily, Monday through Saturday.
http://www.whenigrowup.net/