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Ad hoc
An ad hoc committee is one that is set up for a particular purpose.
Adrenalectomy
Surgical removal of the adrenal glands.
Aesthetically
Tastefully; concerned with appearance.
Agonist
When talking about drugs, this refers to a compound that stimulates or enhances
activity of the cell receptors.
Air lock
In biosafety facilities airlocks are usually two sets of doors in a corridor
which when closed form a series of air locks to prevent air moving in or out
of the area. Only one door should be opened at one time.
Air pressure gradient
Different air pressures in an animal facility's ventilation system can be used
to help create barriers to contain or exclude microorganisms. A clean, biocontainment
room or area, for example, would have a higher air pressure than the corridor,
so that when the door is open, the air flows out rather than in.
Albumin
Albumin is one of the major plasma proteins. It has many functions in the blood
plasma including carrying molecules (and some drugs) throughout the body.
Allergen
Any substance capable of producing a type 1 allergic reaction.
Alpha2 adrenergic receptor agonists
This is a group of pain relieving drugs that includes xylazine and medetomidine.
Alveoli
The alveoli in the lungs are the small grape-like clusters of outpouchings at
the end of the lung's air ducts, where gas exchange (oxygen, carbon dioxide)
takes place.
Anaphylaxis
A generalized allergic reaction (also called anaphylactic shock) in sensitized
individuals that results in life-threatening symptoms which may include vascular
collapse, shock and respiratory distress.
Anoxia
Anoxia means a total lack of oxygen. Often used interchangeably with hypoxia,
which means a reduced supply of oxygen.
Antagonist
When talking about drugs, this refers to a compound that opposes the activity
of the cell receptors.
Anthropomorphic
This term is used to describe a person's attitude when he/she ascribes human
attributes to an animal, or to the animal's experiences or perceptions.
Anti-rejection drugs
People who have received an organ transplant need medication every day to prevent
organ rejection. Drugs called immunosuppressants or anti-rejection drugs help
suppress the immune system to prevent or reverse rejection. At the same time,
these drugs may have side effects. A number of drugs are commonly used for this
purpose.
Anxiolytic
Removing or diminishing anxiety.
Arthritis
Inflammation of the body joints.
Asthma
Asthma is a condition of the lungs caused by constriction of the airways and
mucus secretion. These interfere with normal air movement in the lungs and cause
wheezing.
Association of Universities and Colleges of Canada (AUCC)
AUCC is the national, non-governmental, not-for-profit organization that represents
93 Canadian public and private not-for-profit universities and university-degree
level colleges. They provide a forum for discussion and a framework for action
at the national level, facilitate development of public policy on higher education,
and encourage cooperation among universities. The AUCC is a member organization
of the CCAC, with four representatives on Council. http://www.aucc.ca/en/index.html
Atopy
Atopy is an inherited, familial tendency to develop some form of allergy such
as hay fever, asthma, eczema.
Autoclave
A machine used to sterilize by a combination of steam and pressure.
Axenic
Completely germ free. An axenic rat in an isolator would be one that is free
of all other microorganisms.
Barbiturates
Barbiturates are a group of sedative/anesthetic drugs. Some of these have a
high potential for abuse, and all are controlled drugs.
Benzocaine hydrochloride
Benzocaine is a local anesthetic, often used topically in human medicine. It
is also used to kill amphibians and fish.
Bradycardia
Slowing of the heart rate.
Bradykinin
One of a group of small proteins that actively affect smooth muscle contraction
in blood vessel walls, and so have effects on blood pressure. Bradykinin dilates
blood vessels, and also stimulates pain receptors.
Bronchoconstriction
Narrowing of the air passages in the lungs.
BSE Bovine Spongiform Encephalopathy
Bovine Spongiform Encephalopathy, also known as "Mad Cow Disease",
is a chronic, degenerative disorder affecting the central nervous system of
cattle, which was first diagnosed in Britain in 1986.
Canadian Federation of Humane Societies (CFHS)
The Canadian Federation of Humane Societies is a national charitable body comprised
of animal welfare organizations and individuals, whose purpose is to promote
compassion and humane treatment for all animals. CFHS is a national voice on
animal welfare issues, representing its member societies and branches across
the country, and is a member organization of the CCAC, with three representatives
on Council. The CFHS is committed to ending the suffering of animals by working
with the public, government, industry, the scientific community, educators and
the media on both the national and local levels. http://www.cfhs.ca/index.htm
Carcinogen
A carcinogen is a chemical, physical, or biological substance that is capable
of causing cancer. Often used in reference to chemicals or pollutants. Some
carcinogens are used to produce cancer in research models.
Cardiac arrhythmia
Irregular beating of the heart.
Catecholamines
A group of compounds with active roles in the sympathetic and parasympathetic
nervous systems. This group includes adrenalin (epinephrin is another name for
the same compound) which is a hormone secreted by the adrenal gland, and noradrenalin
(norepinephrin is another name for the same compound). Effects include blood
vessel constriction and increase in blood pressure, and increased heart rate.
Cerebral ischemia
Ischemia refers to a lack of adequate blood flow to an area. Cerebral ischemia
refers to a lack of adequate blood flow to the brain, which may be the result
of a blood clot, blood vessel constriction or a hemorrhage.
Cervical dislocation
A physical euthanasia technique where pressure is applied to the neck to dislocate
the spinal column from the skull, normally only conducted on small animals.
Chemical restraint
Chemical restraint is the use of sedatives or anesthetics to control an animal's
activity and thereby allow certain procedures to be done with minimal stress
to the animal.
Chloramphenicol
Chloramphenicol is an antibiotic once in common use in veterinary medicine but
now banned in food producing animals, due to the potential for bone marrow depression
of blood cell production.
Chronic Wasting Disease (CWD)
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy of
elk and other deer, first recognized the 1960s in Colorado and identified as
a prion disease in the late 1970s. Deer with CWD have been found in game farms,
and wild elk and deer with CWD have been found in the USA and Canada.
Class II Biosafety Cabinet
Class II biological safety cabinets are designed to have air flow drawn around
the operator, into the front of the cabinet to protect the person. Inside the
cabinet a downward laminar flow of HEPA-filtered air protects the product being
handled. There are several types of Class II biosafety cabinets.
CNS
The Central Nervous System consists of the brain and spinal cord, in vertebrates.
Commensal
Commensal means a microorganism that normally lives in close contact with a
human or animal without causing any harm. This would include many of the bacteria
normally present on a person's or animal's skin or intestine.
Conjunctivitis
Inflammation of the membranes of the eyelids and around the eye.
Controlled drug
Controlled drugs are those listed in the schedule to the Narcotic Control Regulations
of the Controlled Drugs & Substances Act, and can only be obtained by a
licensed doctor, dentist or veterinarian, or by special permit for research
purposes. The list includes the barbiturates, and many opiates.
Corticosteroids
Corticosteroids are hormones produced by the adrenal cortex that affect many
body processes. Their properties include anti-inflammatory actions, breakdown
of protein and fat, activation in the nervous system, the body's salt and water
balance, regulation of blood pressure, and so on. Synthetic corticosteroids
are used in many treatments prescribed by physicians and veterinarians.
CT
Computed Tomography, also called Computerized Axial Tomography (CAT) scanning,
is a diagnostic medical tool that uses x rays to obtain a series of cross-section
images of the body which are then integrated using a computer.
Cystitis
Inflammation of the urinary bladder.
Cytokines
Cytokines are a group of compounds that are secreted primarily from white blood
cells when the immune system is activated. They stimulate both the humoral and
cellular immune responses, and activate other cells of the immune system. Some
of the cytokines are called interleukins.
Cytolytic
Cyto - cells; lysis - destruction. Cytolytic ability or capacity refers to the
ability to destroy cells, by a microorganism, for example.
Dander
Small scales from hair or feathers which flake off and can become airborne.
Demeanor
Demeanor refers to a person's bearing ,or behavior towards others.
Discomfort
Discomfort is viewed as a mild form of distress.
Distress
Distress is a state associated with invasive procedures conducted on an animal,
or with restrictive or other conditions which significantly compromise the welfare
of an animal, which may or may not be associated with pain, and where the animal
must devote substantial effort or resources to the adaptive response to challenges
emanating from the environmental situation.
Diurnal rhythm
Most animals (and plants) have a daily rhythm of activity. This is the diurnal
rhythm.
Doppler equipment
A Doppler transducer is one that uses ultrasound to evaluate blood flow inside
the body. The instrument looks like a microphone, and sends and receives silent,
high frequency sound waves.
Edema
Edema is the term used to describe the presence of abnormally large amounts
of fluid in a tissue or organ.
Encephalitis
Refers to infection or inflammation of the brain. Ascending encephalitis refers
to an infection of the nervous tissue that travels up towards the brain and
eventually affects the brain too.
Endorphins
Endorphins are a group of small proteins naturally occurring in the brain around
nerve endings, that bind to opiate receptors and thus can raise the pain threshold.
Enkephalins are included in this group of compounds.
Endpoint
The term "endpoint" can be defined as the point at which an experimental
animal's pain and/or distress is terminated, minimized or reduced by taking
actions such as humanely killing the animal, terminating a painful procedure,
or giving treatment to relieve pain and/or distress.
Eosinophils, neutrophils, lymphocytes
These are different cell types in the white blood cell series. Their numbers
change in many conditions such as disease, distress, toxic states. White blood
cell counts are useful for diagnostic purposes.
Epidural
The epidural space is the space around the spinal cord. Epidural anesthesia
is produced by injecting the analgesic drug (usually a local anesthetic, but
it could also be an opioid) into the epidural space, usually in the lumbar region.
The drug directly affects the spinal cord or the nerve roots arising from the
cord.
Euthanasia
To kill an animal painlessly, and without distress.
Eczema
A skin reaction typically resulting in itchiness, reddening, thickening and
possibly oozing.
Exsanguination
Generally, the excessive loss of blood. As a secondary technique for euthanasia,
it may involve deliberately removing as much blood as possible from an animal.
Ex vivo
Outside the living body, for example removing a liver for studies in a perfusion
apparatus.
First pass metabolism
First-pass metabolism refers to the phenomenon of a drug taken orally which
is absorbed through the intestinal wall and goes directly to the liver through
the portal vein system and gets metabolized there before reaching the target
organ. This is avoided by giving the drugs by other routes (e.g., intramuscular,
intravenous).
Flexible film isolators
Isolators used for housing germ free (axenic) and gnotobiotic animals - a system
with a complete barrier against contamination.
Flight zone
The flight zone is an animal's "personal space". The size of the flight
zone varies with the tameness of the animal, and other animal-related factors.
Wild animals have a much larger flight zone than most domestic animals that
are used to humans.
Fomite
Any object, that is not harmful itself, but may be capable of carrying an infectious
microorganism on it and thus transmit disease.
Formalin
Formalin, or formaldehyde, in solution is used as a tissue preservative and
fixative for tissue specimens.
Garbage in garbage out (GIGO)
This term refers to the fact that computers will process nonsensical, faulty
or incomplete input data and produce nonsensical, faulty or incomplete output.
Gnotobiotic
A gnotobiotic system is a completely closed biological environment in which
all organisms are known. For example, a gnotobiotic mouse could be a mouse that
has only one species of bacteria in its intestine.
Hantavirus Pulmonary Syndrome (HPS)
Hantavirus Pulmonary Syndrome (HPS) is characterized by a sudden onset of fever,
pain, vomiting, and onset of respiratory distress and prostration. Mortality
rates are high despite symptomatic treatment.
Harried
A person or animal who/that is harassed or bothered.
HEPA filter
HEPA filter stands for High Efficiency Particulate Air filter. Such a filter
will be at least 99.97% efficient at removing all particles in the air down
to a size of tenths of a micrometre.
Hepatic
Associated with the liver.
Hepatitis
Inflammation of the liver.
Histamine
A compound found throughout the body, but in highest concentrations in the white
blood cell types that are active in inflammation and allergy responses. Release
of histamine and its effects on tissues are responsible for some of the symptoms
of allergic reactions.
Hypertension
High blood pressure.
Hypophysectomy
Surgical removal of the pituitary (also know as the hypophysis) gland at the
base of the brain.
Hypotension
Low blood pressure.
Hypothalamic-pituitary-adrenal (HPA) axis
The HPA axis refers to the hypothalamic-pituitary-adrenocortical axis. It is
the internal neuroendocrine system that responds to stress and results in production
of corticosteroid hormones that affect the brain, the cardiovascular system,
and other systems in getting the body ready for what is known as the "fight
or flight" mechanism.
Hypoxia, hypoxemia
A state of reduced oxygen in the blood or organs or tissues.
ICCVAM
ICCVAM, the Interagency Coordinating Committee on the Validation of Alternative
Methods, is an agency of the US National Institute of Environmental Health Sciences
(NIEHS), working to develop and validate new safety test methods, and to establish
criteria and processes for the validation and regulatory acceptance of toxicological
testing methods.
Immunocompetent
An animal whose immune system is functioning normally and capable of mounting
an antibody or cell-mediated immune response, is immunocompetent.
Immunocompromised
An animal whose immune system is not functioning normally and that may be incapable
of mounting an antibody or cell-mediated immune response, is immunocompromised.
Some genetic models are immune deficient (immunocompromised). Anti-rejection
drugs also result in compromise of the immune system.
Incubation period
A disease incubation period is the period of time between the actual infection
and the first signs of disease.
Infrastructure
This is the basic supporting structure of an organization. Physical infrastructure
in this context refers to the buildings and animal facilities used to house
experimental animals.
In situ
In situ refers to something that is in its natural or original position.
Intercostal
Situated between the ribs.
Intraperitoneal
Within the peritoneal cavity. An intraperitoneal injection is made into the
peritoneal cavity in the abdomen.
Intravenous
Within a vein. An intravenous injection is made into a vein.
In vitro
In an artificial environment, for example in a test tube.
In vivo
Within the living body.
Irradiated food
There are several types of radiant energy used to sterilize foods. Gamma irradiation
is commonly used to sterilize laboratory animal feeds. The amount of irradiating
energy is controlled to kill all microorganisms, without affecting the quality
of the food.
Keratin
The primary protein of skin, hair, and nails.
Macaque Monkeys
The macaques are a subgroup of the old world monkey and baboon family, that
are widely distributed in Africa, central and southeast Asia, southern China
and Japan. This group includes the rhesus and cynomolgus monkeys – two
types of macaques used in biomedical research.
Malaise
A vague feeling of bodily discomfort or tiredness.
Malignant hyperthermia
An inherited condition in humans and some animals that results in an uncontrolled
increase in body temperature upon exposure to certain anesthetics. Halothane
is a potent trigger of malignant hyperthermia in susceptible animals or people.
At one time, the genetic trait was common in commercial pigs, but it has been
almost eliminated through genetic selection.
Mannequin
An animal mannequin is an anatomical model used for teaching.
Mastitis
Inflammation of the mammary glands.
Metazoan
Multicellular organism (e.g. worms). A protozoan is a unicellular organism.
Microisolator (cages)
The term "microisolator" describes laboratory animal cages that have
an air filter in a frame covering the entire top of the cage, used to minimize
contamination of the animals in the cage.
MRI
Magnetic Resonance Imaging (MRI) is a medical diagnostic technique that creates
images of the body using nuclear magnetic resonance. When a patient is placed
into the cylindrical magnet, the process follows three basic steps. First, MRI
creates a magnetic steady state within the body using a magnetic field 30,000
times stronger than the earth's magnetic field. Then MRI stimulates the body
with radio waves to change the steady-state orientation of protons. It then
stops the radio waves and “listens” to the body's electromagnetic
transmissions at a selected frequency. That signal is used to construct detailed
internal images of the body using a computer program.
MSDS
Material Safety Data Sheets (MSDS) are the internationally standardized way
to document the hazardous properties of chemicals and other hazardous agents.
Chemical companies provide such data sheets, and collections of MSDS sheets
are available from several sources.
Mucosa
The mucosa is the membrane that lines body cavities including the intestine.
Mu receptors
Opioid drugs bind to the mu receptors in the brain and nervous tissue .
Muscarinic actions of acetylcholine
The muscarinic actions of acetylcholine include slowing the heart, increasing
secretions from the salivary gland and respiratory tract. Thus, anti-muscarinic
drugs used as preanesthetics block secretions that might clog up the respiratory
track during anesthesia, and reduce the slowing of the heart rate. Muscarine
is a mushroom-derived alkaloid that mimics certain actions of the neurotransmitter
acetylcholine, hence the term "muscarinic" actions of acetylcholine.
NMDA Receptors
N-methyl-D-aspartate (NMDA) receptors are important for the transmission of
some aspects of pain in the central nervous system. In particular, they appear
to be involved in the development of hypersensitivity that accompagnies injuries
or inflammation
Neuroleptanalgesia
Neuroleptanalgesia is defined as a state of quiescence, altered awareness, and
analgesia produced by the administration of a combination of a neuroleptic agent
and a narcotic (opioid) analgesic.
Neuroma
A neuroma is a tumor growth of nerve cells and fibres. It may occur at the end
of an injured nerve fibre.
OECD - Organisation for Economic Co-operation and Development
The Organisation for Economic Co-operation and Development (OECD) is made up
of a group of 29 member countries sharing a commitment to democratic government
and the market economy. Its work covers economic and social issues, produces
internationally agreed-upon instruments, decisions and recommendations that
allow for rules where multilateral agreements are necessary for individual countries
to make progress in a globalized economy. In the area of safety/toxicity testing
of products, the OECD guidelines set standards for such testing, including when
animals are used.
Pain
Pain is an unpleasant sensory and emotional experience associated with actual
or potential damage or described in terms of such damage.
Peritonitis
Inflammation of the lining of the peritoneal cavity (abdomen).
Phenothiazine derivative drugs
This group of drugs includes commonly used tranquilizers in both human and veterinary
medicine such as acepromazine, chlorpromazine.
pH
pH is the symbol given to the hydrogen ion concentration in a liquid. pH 7 is
neutral; higher pH is alkaline, lower pH is acidic.
Piloerection
Standing up of the body hair.
Pithing
Pithing is a physical method of rendering an animal brain dead by destroying
the cerebral hemispheres. A sharp probe is introduced into the brain cavity
through the foramen magnum to accomplish this.
Placenta
The membranes surrounding the fetus in the womb.
Positive pressure ventilated suits
Positive pressure ventilated suits are worn by personnel who have to work in
maximum containment (level 4 biocontainment). They are sealed suits with their
own filtered air ventilation.
Pre-emptive analgesia
This refers to the administering of pain relieving drugs before the pain is
expected to begin, for example giving analgesics before anesthesia and surgery
begin.
Prion
Prions are infectious agents which (almost certainly) do not have nucleic acid
- a protein alone seems to be the infectious agent. Prions are small proteinaceous
infectious particles which resist inactivation by procedures that modify nucleic
acids. Prion diseases are often called spongiform encephalopathies because of
the post-mortem appearance of the brain with large "holes" in the
cortex and cerebellum.
Prion Diseases
Prion diseases are often called spongiform encephalopathies because of the post-mortem
appearance of the brain with large "holes" in the cortex and cerebellum.
Examples include: scrapie in sheep; CWD (chronic wasting disease) in elk and
other deer; BSE (bovine spongiform encephalopathy) in cattle. Human prion diseases
include: CJD (Creutzfeld-Jacob Disease); Kuru; Alpers Syndrome.
Prostaglandin
The prostaglandins are a group of fatty acid compounds that have many effects
throughout the body, including activity in inflammation, smooth muscle contraction,
regulating body temperature, and effects on certain hormones.
Protozoan
A unicellular organism (e.g. bacteria). A metazoan is a multicellular organism.
Pulse oximeter
A pulse oximeter is an external probe that uses light bounced off the blood
vessels under the probe to determine level of oxygenation of the hemoglobin
in the blood cells, through a computer calculation. The pulses of blood with
the heart rate are detected.
Purpose-bred laboratory animals
Animals specifically bred for scientific purposes.
Quarantine
Refers to the confinement or isolation of animals which may be carrying an infectious
disease, usually for a specified period of time, to allow for testing.
Red light test
To accurately evaluate changes in the level of activity in rodents, the room
lights can be turned off and using only a red light, their “normal”
activity level will emerge after about 5 minutes. This is the “red light
test”.
Reflex
Reflex usually describes an immediate involuntary response evoked by a stimulus,
for example the cough reflex.
Ringtail
Ringtail in the rat is a condition in young suckling rats and mice, believed
to be caused by low relative humidity (less than about 30%). There are annular
constrictions on the tail that may progress to necrosis and sloughing of the
tail tip. Ringtail can be prevented by maintaining relative humidity at approximately
50%.
Scalpel
A scalpel is a small surgical knife with a handle onto which a blade is placed.
Scavenge, scavenger, scavenging
In a surgery room, the scavenging system is used to exhaust all waste anesthetic
gasses out of the room to minimize risk of exposure of people to the anesthetic
gas.
Scrapie
Scrapie is a transmissible spongiform encephalopathy - a fatal, degenerative
disease affecting the central nervous system of sheep and goats, believed to
be caused by prions.
Sentinel animal
A sentinel animal is an animal known to be susceptible to an infectious agent
that is placed in the area suspected of being contaminated, for example in a
new shipment of laboratory animals under quarantine. That animal is then tested
to see if it became infected or developed antibodies to infectious agents.
SPF (Specified Pathogen Free)
Specified Pathogen Free is a designation used to describe the health status
of animals. It means that a specific list of potentially infectious organisms
have been tested for, and not found in an animal or group of animals.
Standard Operating Procedure (SOP)
Standard operating procedures are written documents that describe in detail,
step-by-step, how a procedure should be done.
Stereotypy
In animal behavior, stereotypies have been defined as behaviors that are repetitive,
performed the same way each time, and seem to serve no obvious purpose or function.
They may be compulsive behaviors that have become displaced, perhaps due to
boredom, frustration, or unresolved stress.
Subarachnoid space
Injections of local anesthetic into the lumbar subarachnoid space are often
called "spinal anesthesia", because they affect the preganglionic
fibers in the spinal cord. The intent is to produce complete spinal cord "denervation"
including all sensory and motor neurons in the area.
T cells
The T cells are cells derived from the thymus that play a major role in a variety
of cell-mediated immune reactions. (B cells are also important in immunity because
they synthesize and secrete antibodies which protect animals from infection,
viruses, etc.)
Tetanus
The disease called Tetanus occurs when a wound becomes infected with bacterial
spores of Clostridium tetani. These spores grow and produce a very powerful
toxin which affects the muscles by producing rigidity, and in severe cases convulsions.
Treatment is difficult, and vaccination is the only way to provide safe, effective
long-term protection against tetanus.
Thoracotomy
Surgery through the chest wall.
Thyroidectomy
Surgical removal of the thyroid glands.
Tidal volume
The Tidal Volume in the lungs is the amount (volume) of air inhaled and exhaled
with each normal breath.
Ultrasonic
Sound waves that are too high for humans to hear are "ultrasonic".
The hearing range of many animals, including rodents, extends much higher than
for humans.
Vagus nerve
The vagus nerve is the tenth cranial nerve. It is the longest of the cranial
nerves and its name derives from the Latin meaning "wandering". The
vagus nerve wanders from the brain stem through organs in the neck, chest and
abdomen. It supplies both sensory and motor fibres to parts of the neck and
chest, and to both the sympathetic and parasympathetic nervous systems to organs
in the chest and abdomen.
Vasodilation
Dilation of the blood vessels (veins, arteries). Usually is accompanied by a
drop in blood pressure.
Vector
A carrier, particularly the animal (e.g. an insect or mite) that can transfer
an infectious organism from one host to another.
Virulence
The degree to which an infectious organism can cause serious disease or invade
the host tissue.
WHMIS
The Workplace Hazardous Materials Information System (WHMIS) is Canada's hazard
communication system. The system includes labelling of containers of "controlled
products", provision of material safety data sheets (MSDS) and worker education
programs. The system is implemented through legislation, and administered by
Health Canada. Employers are required to
ensure that controlled products used, stored, handled or disposed of in the
workplace are properly labelled, MSDSs are made available to workers, and workers
receive education and training to ensure the safe storage, handling and use
of controlled products.
Windup
In some forms of ongoing pain, the spinal cord and brain receive pain signals
over a considerable period of time. There can be adaptation by the spinal cord
that results in the incoming pain signal becoming amplified in a phenomenon
known as windup pain. This means the pain signal reaching the brain is stronger
than before, and the ability of other pathways to modify (decrease) the sensation
is diminished.
Zoonosis
A zoonosis is a disease of animals that may, under natural conditions, be secondarily
transmitted to humans - a disease that is communicable between animals and humans.
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