Did another universe collapse give birth to the one we live in today?

"My paper introduces a new mathematical model that we can use to derive new details about the properties of a quantum state as it travels through the Big Bounce, which replaces the classical idea of a Big Bang as the beginning of our universe," said Martin Bojowald, assistant professor of physics at Penn State.

Bojowald's research also suggests that, although it is possible to learn about many properties of the earlier universe, we always will be uncertain about some of these properties because his calculations reveal a "cosmic forgetfulness" that results from the extreme quantum forces during the Big Bounce.

In what they call a “stunning research advance,” investigators at Georgetown University Medical Center have been able to use simple, non-toxic chemical injections to add and remove fat in targeted areas on the bodies of laboratory animals.

They say the discovery could revolutionize human cosmetic and reconstructive plastic surgery and treatment of diseases associated with human obesity.

Investigators say these findings may also, over the long-term, lead to better control of metabolic syndrome, which is a collection of risk factors that increase a patient’s chances of developing heart disease, stroke, and diabetes. Sixty million Americans were estimated to be affected by metabolic syndrome in 2000, according to a study funded by the Centers for Disease Control in 2004.

In the last 40 years, scientists have perfected ways to determine the knot-like structure of enzymes, but they’ve been stumped trying to translate the structure into an understanding of function – what the enzyme actually does in the body. This puzzle has hindered drug discovery, since many of the most successful drugs work by blocking enzyme action.

Variations in the WFS1 gene, known to affect both the survival and function of insulin-producing cells in the pancreas, can be linked to type 2 diabetes susceptibility, according to a new study from Cambridge.

The study has two major implications – it identifies a new risk factor in a disease reaching epidemic levels worldwide while also showing that variations in a gene – and not only mutations – can lead to type 2 diabetes.

Ongoing field trials since 2002 by a team that includes 16 farmers, Cornell researchers and Cornell Cooperative Extension field crops educators in 10 counties are showing the value of on-farm research. Their results are successfully quantifying and predicting the nitrogen needs for growing corn, saving farmers money and reducing environmental impact.

"With this program, we focus on determining under what situations extra nitrogen would be good to add and when a farmer can save money by reducing fertilizer applications without impacting yield and quality," says Quirine Ketterings, associate professor of crop and soil sciences, who co-leads the research team. "This is the best way to minimize the potential negative environmental and economic impacts of excess nitrogen fertilizer use."

Early use of new DNA sequencing technology enables scientists to create whole genome maps of chromatin in embryonic stem cells and other cells

As a fertilized egg develops into a full grown adult, mammalian cells make many crucial decisions — closing doors of opportunity as they adopt careers as liver cells, skin cells, or neurons. One of the most fundamental mysteries in biomedicine is how cells make such different career decisions despite having exactly the same DNA. By using a new kind of genomic technology, a new study unveils a special code — not within DNA, but within the so-called “chromatin” proteins surrounding it — that could unlock these mysterious choices underlying cell identity.

Researchers at the Salk Institute for Biological Studies have developed a novel strategy to expand the natural repertoire of 20 amino acids in mammalian cells, including neurons, and successfully inserted tailor-made amino acids into proteins in these cells. In a powerful demonstration of the method’s versatility, they then used unnatural amino acids to determine the operating mechanism of the “molecular gates” that regulate the movement of potassium ions in and out of nerve cells.

“In the past, this type of engineering has been mainly restricted to bacteria or in yeast, and it was very challenging to efficiently incorporate unnatural amino acids in mammalian cells. But most biomedical questions have to be studied in the cells of higher organisms and animal models to arrive at meaningful answers,” explains Lei Wang, Ph.D., an assistant professor in the Chemical Biology and Proteomics Laboratory.

Professor Herbert Herzog, Director of the Neuroscience Research Program at the Garvan Institute of Medical Research, together with scientists from the US and Slovakia, have shown that neuropeptide Y (NPY), a molecule the body releases when stressed, can ‘unlock’ Y2 receptors in the body’s fat cells, stimulating the cells to grow in size and number. By blocking those receptors, it may be possible to prevent fat growth, or make fat cells die.

“We have known for over a decade that there is a connection between chronic stress and obesity,” said Professor Herzog. “We also know that NPY plays a major role in other chronic stress-induced conditions, such as susceptibility to infection. Now we have identified the exact pathway, or chain of molecular events, that links chronic stress with obesity.”

A just published scientific study conducted by researchers at the University of Miami School of Nursing in conjunction with The Sirkin Creative Living Center (SCLC) has found that Rescue Remedy®, an all-natural remedy created from flower essences, is an effective over-the-counter stress reliever with a comparable effect to traditional pharmaceutical drugs yet without any of the known adverse side effects, including addiction.

Rescue Remedy contains five flower essences: Rock Rose to alleviate terror and panic, Impatiens to mollify irritation and impatience, Clematis to combat inattentiveness, Star of Bethlehem to ease shock, and Cherry Plum to calm irrational thoughts. Available in a convenient spray bottle or in drop form, it helps to provide better emotional balance and fast, convenient relief from everyday stress.

A role for prion proteins, the much debated agents of mad cow disease and vCJD, has been identified. It appears that the normal prions produced by the body help to prevent the plaques that build up in the brain to cause Alzheimer’s disease. The possible function for the mysterious proteins was discovered by a team of scientists led by Medical Research Council funded scientist Professor Nigel Hooper of the University of Leeds.

Alzheimer’s and diseases like variant Creutzfeldt-Jakob Disease follow similar patterns of disease progression and in some forms of prion disease share genetic features. These parallels prompted Professor Hooper’s team to look for a link between the different conditions. They found an apparent role for normal prion proteins in preventing Alzheimer’s disease.

The most common procedure for clearing blocked kidney arteries can also release thousands of tiny particles into the bloodstream that can impair kidney function, according to researchers from Wake Forest University Baptist Medical Center and colleagues.

“This is the first data in humans to show that debris released during angioplasty and stenting of the kidney arteries can be harmful to kidney function,” said Matthew Edwards, M.D., M.S., lead researcher and an assistant professor of surgery. “It raises important questions about how to most safely perform this very common procedure.”

Women with at least three sites of cellular atypia in breast tissue are nearly eight times more likely than average women to develop breast cancer, according to findings of a Mayo Clinic Cancer Center-led study of women with atypical hyperplasia. The findings are published in the July 1 issue of the Journal of Clinical Oncology.

Several previous studies have shown that atypical hyperplasia (also called atypia) in breast tissue is a major risk factor for breast cancer. Women who have a breast biopsy and are diagnosed with atypia are considered at high risk. Many are counseled to consider preventive medications such as tamoxifen or other risk-reducing approaches. However, questions remained from prior research on whether a positive family history further increases risk in women with atypia and for how long the increased risk in women with atypia lasts.

The first pigs containing genes responsible for Alzheimer’s disease will be born in Denmark in August. This event is a landmark achivement in the effort towards finding a cure for the disease.

Scientists from the universities of Copenhagen and Århus, Denmark are once again at the cutting edge of biotechnology. This time with cloned pigs that have been genetically modified so that they may function as animal models for the notorious Alzheimer’s disease. In the US alone, 5 million people suffer from this human brain disorder and globally the number is set at approx. 24 million (source: Alzheimer's Disease International).

Bats are one of the zoological groups attracting most interest around the world in terms of studying the epidemiology of rabies.

However, the dynamics of the viral infection in these organisms remains poorly understood. A team from the UB and the Institut Pasteur in Paris has just reported the first epidemiological, ecological and virological study with previously unpublished data on the transmission and development of rabies in these mammals.

The study is the result of twelve years of monitoring the dynamics of rabies virus infection (European bat lyssavirus subtype 1 - EBL1) in two wild bat (Myotis myotis) colonies in Spain. In total, the scientific data refer to the monitoring of over 1000 individuals from two colonies situated 35 km from one another.

In May, Nobel Laureate James D. Watson, the scientist who co-discovered the structure of DNA, became the first person to receive his own complete personal genome -- all three billion base pairs of his DNA code sequenced. The cost was $1 million, and the process took two months.

A million dollars for a map of all your genes is way out of reach for most people. The National Institutes of Health would like to bring it down to $1,000 by the year 2014, but plenty of technological hurdles remain before you’ll be able to secure your genetic blueprint for this more affordable price.

A factor in immune cells regulates human semen and seems to determine whether a man will be fertile, according to a new study.

Yousef Al-Abed, PhD, and his colleagues at The Feinstein Institute for Medical Research have isolated an immune substance called macrophage migration inhibitory factor (MIF) in semen samples from infertile and reproductively healthy men. MIF is key to helping sperm mature, which is necessary for its union with an egg. The finding could lead to a diagnostic test to determine fertility status.

Using echo-sounding equipment to create images and maps of areas below the ocean floor, researchers have begun to unravel a new story about the Antarctic Ice Sheet.

Images of areas below the Eastern Ross Sea, next to West Antarctica, provide evidence that the subcontinent was involved in the general growth of the Antarctic Ice Sheet as it formed many millions of years ago, according to scientists at the University of California, Santa Barbara. The National Science Foundation provided funding for the project.

Changes in Antarctica, an area that contains approximately 90 percent of the world’s ice, are particularly important for understanding some implications of global warming. For example, melting of ice sheets –– due to warming of the atmosphere and oceans –– has emerged as a key factor in the modeling of climate scenarios. And as ice melts, habitat for penguins and other marine animals also decreases.

The Genographic Project is studying the genetic signatures of ancient human migrations and creating an open-source research database. It allows members of the public to participate in a real-time anthropological genetics study by submitting personal samples for analysis and donating the genetic results to the database.

In the first scientific publication from the project they report on genotyping human mitochondrial DNA during the first 18 months of the project.

To making sorting and cataloguing so much data easier, they created the Nearest Neighbor haplogroup prediction tool. The accurate classification of genetic lineages into distinct branches on the human family tree, known as haplogroups, has long been a struggle for anthropologists.

About 250 years before Daniel Massey built his farm house in Huntingdon County, Pennsylvania, his great-grandfather came to the New World as an indentured servant. 150 years later, Penn State's Archaeological Field School is excavating Daniel's house to see how far he came from those humble beginnings.

"I think historic archaeology can engage a little more directly than the prehistoric archaeology we sometimes do," says Dr. Claire Milner, director of the field school and director of exhibits and curator of Penn State's Matson Museum of anthropology. "It is more obvious and immediate who the people were and what the artifacts are."