Santa Jeremy Ono sponsors free access to F1000 for Bulgarian Academy of Sciences, Sofia, Bulgaria. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Contact Details:
Emory University
Office of the Provost
404 Administration Building
201 Dowman Drive
Atlanta, GA 30322-1950
Telephone: (001) 404-727-0313
Fax: (001) 404-727-1090
e-mail: sjono@emory.edu

Research Interests:

Cell and molecular basis of type I hypersensitivity reactions. Role of chemokines and cytokines in the inductive and effector phases of allergic reactions. Gene regulation in the immune system. Role of HMG A1 and A2 proteins in gene activation, differentiation and tumorigenesis.

Eotaxin selectively binds heparin. An interaction that protects eotaxin from proteolysis and potentiates chemotactic activity in vivo. Ellyard JI, Simson L, …, Freeman C, Parish CR J Biol Chem 2007 May 18 282(20):15238-47 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 3 Apr 2007 Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. Voehringer D, van Rooijen N, Locksley RM J Leukoc Biol 2007 Jun 81(6):1434-44 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 19 Mar 2007 Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Djuretic IM, Levanon D, …, Rao A, Ansel KM Nat Immunol 2007 Feb 8(2):145-53 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono / Kathryn Calame Evaluated 11 Jan 2007 IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. Temann UA, Laouar Y, …, Homer R, Flavell RA Int Immunol 2007 Jan 19(1):1-10 [abstract on PubMed] [related articles] [full text] [order article] Selected by | David Chaplin / Santa Jeremy Ono Evaluated 1 Dec 2006 Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a. Munitz A, Bachelet I, Levi-Schaffer F J Allergy Clin Immunol 2006 Nov 118(5):1082-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 27 Nov 2006 Distinct roles of Ca2+ mobilization and G protein usage on regulation of Toll-like receptor function in human and murine mast cells. Zaidi AK, Thangam ER, Ali H Immunology 2006 Nov 119(3):412-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 9 Nov 2006 T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. Usui T, Preiss JC, …, O'Shea JJ, Strober W J Exp Med 2006 Mar 20 203(3):755-66 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 12 May 2006 Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Abonia JP, Hallgren J, …, Austen KF, Gurish MF Blood 2006 Sep 1 108(5):1588-94 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 12 May 2006 Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses. Erin EM, Leaker BR, …, Barnes PJ, Hansel TT Clin Exp Allergy 2006 Apr 36(4):458-64 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 3 May 2006 Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. Furumoto Y, Brooks S, …, Gilfillan AM, Rivera J J Immunol 2006 May 1 176(9):5167-71 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 28 Apr 2006 Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Inoue T, Boyle DL, …, Flavell RA, Firestein GS Proc Natl Acad Sci U S A 2006 Apr 4 103(14):5484-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 10 Apr 2006 Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. Kim DC, Hsu FI, …, Austen KF, Kanaoka Y J Immunol 2006 Apr 1 176(7):4440-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 3 Apr 2006 CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. Akbari O, Faul JL, …, DeKruyff RH, Umetsu DT N Engl J Med 2006 Mar 16 354(11):1117-29 [abstract on PubMed] [related articles] [FREE full text] Selected by | Eckhard Podack / Santa Jeremy Ono / Randy Brutkiewicz / Toshinori Nakayama Evaluated 24 Mar 2006 Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities. Pang L, Nie M, …, Sutcliffe A, Knox AJ J Immunol 2006 Mar 15 176(6):3788-95 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 16 Mar 2006 Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. Lee KS, Lee HK, …, Lee YC, Puri KD FASEB J 2006 Mar 20(3):455-65 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 10 Mar 2006 Functional hierarchy of the N-terminal tyrosines of SLP-76. Jordan MS, Sadler J, …, Schwartzberg PL, Koretzky GA J Immunol 2006 Feb 15 176(4):2430-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 10 Feb 2006 Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13. Guo L, Hu-Li J, Paul WE Immunity 2005 Jul 23(1):89-99 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 9 Aug 2005 Prolactins are natural inhibitors of angiogenesis in the retina. Aranda J, Rivera JC, …, Martínez de la Escalera G, Clapp C Invest Ophthalmol Vis Sci 2005 Aug 46(8):2947-53 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 9 Aug 2005 Jak3 negatively regulates dendritic-cell cytokine production and survival. Yamaoka K, Min B, …, Paul WE, O'shea JJ Blood 2005 Nov 1 106(9):3227-33 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 20 Jul 2005 Asthmatic changes in mice lacking T-bet are mediated by IL-13. Finotto S, Hausding M, …, Galle PR, Glimcher LH Int Immunol 2005 Aug 17(8):993-1007 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 15 Jul 2005 Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. Zheng T, Kang MJ, …, Schmidt JA, Elias JA J Immunol 2005 Jun 15 174(12):8106-15 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 22 Jun 2005 Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. Ying S, O'Connor B, …, Lee TH, Corrigan C J Immunol 2005 Jun 15 174(12):8183-90 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 22 Jun 2005 A critical control element for interleukin-4 memory expression in T helper lymphocytes. Tykocinski LO, Hajkova P, …, Paul WE, Radbruch A J Biol Chem 2005 Aug 5 280(31):28177-85 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono / Mark Bix / Dean Sheppard Evaluated 20 Jun 2005 Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge. Ravensberg AJ, Ricciardolo FL, …, Hiemstra PS, Mauad T J Allergy Clin Immunol 2005 Apr 115(4):779-85 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 27 May 2005 Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. Abonia JP, Friend DS, …, Stevens RL, Gurish MF J Immunol 2005 Jun 1 174(11):7285-91 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 27 May 2005 A role for caspases in controlling IL-4 expression in T cells. Sehra S, Patel D, …, Chang CH, Dent AL J Immunol 2005 Mar 15 174(6):3440-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 6 May 2005 The chemokine receptor D6 limits the inflammatory response in vivo. Jamieson T, Cook DN, …, Wiekowski M, Graham GJ Nat Immunol 2005 Apr 6(4):403-11 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steve Ward / Barry Rouse / Santa Jeremy Ono Evaluated 29 Apr 2005 TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. Orinska Z, Bulanova E, …, Maurer M, Bulfone-Paus S Blood 2005 Aug 1 106(3):978-87 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 27 Apr 2005 Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment. Jee YK, Gilmour J, …, Lee T, Lavender P J Biol Chem 2005 Jun 17 280(24):23243-50 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 22 Apr 2005 Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. Takhar P, Smurthwaite L, …, Durham SR, Gould HJ J Immunol 2005 Apr 15 174(8):5024-32 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 14 Apr 2005 Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Fontenot JD, Rasmussen JP, …, Farr AG, Rudensky AY Immunity 2005 Mar 22(3):329-41 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Chen Dong / Santa Jeremy Ono / Torben Lund / Christopher Karp / Paul Gleeson Evaluated 13 Apr 2005 Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Wan YY, Flavell RA Proc Natl Acad Sci U S A 2005 Apr 5 102(14):5126-31 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono / Torben Lund / Christopher Karp Evaluated 8 Apr 2005 Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. Yasuda S, Morokawa N, …, Krilis SA, Stevens RL Blood 2005 May 15 105(10):3893-901 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 23 Feb 2005 Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. Abonia JP, Austen KF, …, Koni PA, Gurish MF Blood 2005 Jun 1 105(11):4308-13 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 22 Feb 2005 T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH Science 2005 Jan 21 307(5708):430-3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Dean Sheppard / George Yap / Santa Jeremy Ono / Christopher A. Hunter / Thomas Graf Evaluated 2 Feb 2005 Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors. Fiebiger E, Tortorella D, …, Kinet JP, Ploegh HL J Exp Med 2005 Jan 17 201(2):267-77 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 25 Jan 2005 Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase. Urtz N, Olivera A, …, Rivera J, Baumruker T Mol Cell Biol 2004 Oct 24(19):8765-77 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 23 Sep 2004 Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Miller AT, Wilcox HM, Lai Z, Berg LJ Immunity 2004 Jul 21(1):67-80 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 23 Sep 2004 The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. Furumoto Y, Nunomura S, …, Rivera J, Ra C J Biol Chem 2004 Nov 19 279(47):49177-87 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 16 Sep 2004 Chromatin-level regulation of the IL10 gene in T cells. Im SH, Hueber A, …, Kang KH, Rao A J Biol Chem 2004 Nov 5 279(45):46818-25 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 3 Sep 2004 Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mowen KA, Schurter BT, …, David M, Glimcher LH Mol Cell 2004 Aug 27 15(4):559-71 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono / Steve Ward Evaluated 3 Sep 2004 Lysophosphatidic acid accelerates the development of human mast cells. Bagga S, Price KS, …, Austen KF, Boyce JA Blood 2004 Dec 15 104(13):4080-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 31 Aug 2004 Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. Min B, Prout M, …, LeGros G, Paul WE J Exp Med 2004 Aug 16 200(4):507-17 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono / Richard Grencis Evaluated 26 Aug 2004 Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3. Kulka M, Alexopoulou L, Flavell RA, Metcalfe DD J Allergy Clin Immunol 2004 Jul 114(1):174-82 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 23 Jul 2004 Allergen activates peripheral blood eosinophil nuclear factor-kappaB to generate granulocyte macrophage-colony stimulating factor, tumour necrosis factor-alpha and interleukin-8. Coward WR, Sagara H, …, Holgate ST, Church MK Clin Exp Allergy 2004 Jul 34(7):1071-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 23 Jul 2004 Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis. Iwanaga T, McEuen A, …, Holgate ST, Holloway JW Clin Exp Allergy 2004 Jul 34(7):1037-42 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 23 Jul 2004 CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. Omori M, Yamashita M, …, Taniguchi M, Nakayama T Immunity 2003 Aug 19(2):281-94 [abstract on PubMed] [related articles] [order article] Selected by | Santa Jeremy Ono Evaluated 12 Sep 2003 Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population. Beghé B, Barton S, …, Holgate ST, Holloway JW Clin Exp Allergy 2003 Aug 33(8):1111-7 [abstract on PubMed] [related articles] [order article] Selected by | Santa Jeremy Ono Evaluated 11 Sep 2003 Munc18-2/syntaxin3 complexes are spatially separated from syntaxin3-containing SNARE complexes. Pombo I, Rivera J, Blank U FEBS Lett 2003 Aug 28 550(1-3):144-8 [abstract on PubMed] [related articles] [order article] Selected by | Santa Jeremy Ono Evaluated 10 Sep 2003 Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. Yotsumoto K, Okoshi Y, …, Nakauchi H, Shibuya A J Exp Med 2003 Jul 21 198(2):223-33 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 4 Aug 2003 Regulation of the Th2 cytokine locus by a locus control region. Lee GR, Fields PE, Griffin TJ, Flavell RA Immunity 2003 Jul 19(1):145-53 [abstract on PubMed] [related articles] [order article] Selected by | Santa Jeremy Ono / Steven Reiner Evaluated 4 Aug 2003 Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Matsuda JL, Gapin L, …, Locksley RM, Kronenberg M Proc Natl Acad Sci U S A 2003 Jul 8 100(14):8395-400 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 10 Jul 2003 Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Akbari O, Stock P, …, DeKruyff RH, Umetsu DT Nat Med 2003 May 9(5):582-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Dean Sheppard / Santa Jeremy Ono Evaluated 19 Jun 2003 Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice. Kobayashi T, Iijima K, Kita H J Immunol 2003 Jun 1 170(11):5756-63 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono / Richard L. Stevens Evaluated 19 Jun 2003 Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. Gonzalez-Espinosa C, Odom S, …, Penninger JM, Rivera J J Exp Med 2003 Jun 2 197(11):1453-65 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 19 Jun 2003 Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. Francis JN, Till SJ, Durham SR J Allergy Clin Immunol 2003 Jun 111(6):1255-61 [abstract on PubMed] [related articles] [order article] Selected by | Santa Jeremy Ono Evaluated 19 Jun 2003 T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Lugo-Villarino G, Maldonado-Lopez R, …, Penaranda C, Glimcher LH Proc Natl Acad Sci U S A 2003 Jun 24 100(13):7749-54 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono / Eric Denkers Evaluated 18 Jun 2003 Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Hoshino A, Tanaka Y, …, Yagita H, Okumura K Eur J Immunol 2003 Apr 33(4):861-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Santa Jeremy Ono Evaluated 2 Jun 2003 Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. Yoshimoto T, Min B, …, Paul WE, Nakanishi K J Exp Med 2003 Apr 21 197(8):997-1005 [abstract on PubMed] [related articles] [FREE full text] Selected by | Santa Jeremy Ono Evaluated 2 Jun 2003

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