414/514 Immunology Principles
415/515 Immunology Principles and Practice

Immunoglobulin Structure and Function

Antibodies are immunoglobulins ... glycoproteins that are formed in response to an immunogenic antigen (immunogen) and which react specifically with that antigen

Feature

IgG

IgA

IgM

IgD

IgE

Sedimentation Coefficient

7S

7S, 9S, 11S

19S

7S

8S

Molecular Weight (kD)

150

160, 395

900

185

200

Heavy Chain Type

gamma

alpha

mu

delta

epsilon

Molecular Formulas

H2L2

H2L2

H4L4JSC

H10L10J

H2L2

H2L2

Valence

2

2, 4

5 (10)

2

2

Concentration in Serum (mg/ml)

8-16

1.4-4

0.5-2

0-0.4

0.02-0.5

Percentage of Total Ig in Serum

80

13

6

0-1

0.002

Carbohydrate Content

3%

8%

12%

13%

12%

Complement Activation

+++ (C1)

+ (Alt)

+++++ (C1)

-

-

Binds Fc Receptor (FcR)

MP, PMN, B

-

-

-

Mast Cells

Crosses Placenta

+++

-

-

-

-

Hypersentitivity

Types II, III

-

Types II, III

-

Type I

Cell Receptor on:

Mature B Cells

Mature B Cells

Immature and mature B Cells

Mature B Cells

Mature B Cells


Course Outline

Objectives (MBI 414/514)

Objectives (MBI 415/515)

Study Tips

Immuno FAQs

Study Guides

Evaluation (MBI 414/514)

Evaluation (MBI 415/515)

Grades

Immuno Sites

Sample Questions

 

Laboratory

Instructor

Bugs'n'Drugs


© 1996-2008 John R. Stevenson. All Rights Reserved

Please
email questions and comments to:
John R. Stevenson, Ph.D.
Associate Professor
Department of Microbiology
Miami University
Oxford, Ohio 45056
USA
This document was last modified on Friday, 19-Sep-2008 16:06:12 EDT