28 November, 2008
Volume 135, Issue 5

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Volume 135, Issue 5

On the cover: An artistic rendition depicts new measurement devices to study cells undergoing endoplasmic reticulum (ER) stress, a condition that occurs whenever ER protein-folding functions are overwhelmed by increased protein-folding demand. Cells are recognized as experiencing ER stress when they have activated a set of homeostatic intraorganelle signaling pathways called the unfolded protein response (UPR), but how the ER is actually faring under these conditions is often less clear. In this issue, Merksamer et al. (pp. 933–947) simultaneously monitored dynamic changes in UPR activity by using transcriptionally activated red fluorescent protein and deficits in ER oxidation occurring during ER stress by using redox-responsive green fluorescent protein. In the drawing, entitled “Redlining the ER,” the measurement tools are likened to gauges on a speeding racecar, which depicts an ER-stressed cell compensating through UPR activation. These tools provide real-time information on these multiple parameters to the experimenters—much as the gauges would to a racecar driver. Conceptual design by Feroz R. Papa and Jennifer West. Artwork by Jennifer West.

Most Read Papers

  • These are the most read by download from the Cell web site for the last 30 days.


Simulation of kinesin-5-mediated chromosome congression at the metaphase spindle
Kinetochore microtubules (MTs) have their minus end attached to the spindle pole body and their dynamic plus end attached to a kinetochore (teal, attached to left pole; purple, attached to right pole). The chromatin between each teal and purple kinetochore pair is not shown. Kinesin-5 motors crosslink MTs and move toward the plus ends (magenta if crosslink is antiparallel, and green if crosslink is parallel). Over time, length-dependent MT assembly self-organizes the spindle, with teal kinetochores clustering on the left and purple kinetochores clustering on the right. The chromosomes are now "congressed" and ready for anaphase. See also the paper by Gardner et al.



SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. Click here, for a full list of SnapShots.


SnapShot: Cell-Cycle Regulators II
David O. Morgan

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In this Issue

Food intake is inhibited by the phospholipid NAPE
Gut-derived serotonin impacts bone formation
A fly model of a lysosomal storage disorder
In vivo RNAi screen identifies new tumor suppressors
A polarity gene and an oncogene cooperate for tumor progression
Changes in chromosome copy number facilitate adaptive evolution
Kinesin-5 disassembles long kinetochore microtubules
SIRT1 redistribution links DNA damage and aging
RNase P makes two noncoding RNAs from a single transcript
Monitoring unfolded proteins in the ER of living cells
Control of adhesion by a microtubule-anchoring machinery
Kinesins act as gatekeeper for memory storage

Immediate Early Publication

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
Anne Wilson, Elisa Laurenti, Gabriela Oser, Richard C. van der Wath, William Blanco-Bose, Maike Jaworski, Sandra Offner, Cyrille F. Dunant, Leonid Eshkind, Ernesto Bockamp, Pietro Lió, H. Robson MacDonald, and Andreas Trumpp

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
Jonathan F. Lovell, Lieven P. Billen, Scott Bindner, Aisha Shamas-Din, Cecile Fradin, Brian Leber, and David W. Andrews

Featured Article

Featured articles are freely available to all readers

The evolvablity of an organism or a cell is defined by its ability to adapt, through heritable changes, to environmental or internal perturbations. Rancati et al. probe the evolvablity of budding yeast deprived of a motor protein central to cytokinesis and find that rapid adaptation occurs and is associated with the acquisition of abnormal chromosome copy numbers.
In this PaperClip, Dr. Karen Carniol speaks with Dr. Rong Li about her group’s study on the evolvability of cellular processes and the role of polyploidization and aneuploidization therein.

Dr. Rong Li

Leading Edge Featured Article

In this Review, Ian Macara and Stavroula Mili examine the origins of cell polarization in unicellular life and its impact in multicellular organisms on the differential inheritance of proteins, RNA, and membranes.

Polarity and Differential Inheritance—Universal Attributes of Life?
Ian G. Macara and Stavroula Mili

Cell PaperClips

Dr. Kai Wucherpfennig Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ε Cytoplasmic Tyrosine-Based Motif
Dr. Fabiola Rivas speaks with Dr. Kai Wucherpfennig about activation of immune receptors and his recent findings showing that a key signaling motif in the CD3ε cytoplasmic domain of the T cell receptor is membrane bound prior to receptor activation.

You can listen directly by clicking on the player above. For a complete list of Cell PaperClips, click here

Cell Podcast

In our latest podcast, we hear from Dr. Gokhan Hotamisligil about a new lipid hormone produced by fat that might help to keep you thin. We learn from Dr Ralph Steinman, who discovered dendritic cells 35 years ago, about using these elusive cells to make better vaccines.

We also hear from Dr Elizabeth Phelps about regions of the brain that control responses to fearful memories. Finally, stay tuned for our quarterly roundup of exciting research highlights published in the Cell Press family of journals.

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