|
1. |
Scx and E47 might modulate the primary chondrogenesis by associating with the Sox9-related transcriptional complex, and by binding to the conserved E-box on Col2a1 promoter. |
|
|
2. |
performed immunohistochemical analysis for Sox9 to examine the possible chondrogenic nature of chondroblastoma and chondromyxoid fibroma. Sox9 was positive in 8 chondroblastomas and 10 chondromyxoid fibromas. |
|
|
3. |
Mutation analysis of SOX9 in eight patients with campomelic dysplasia or acampomelic campomelic dysplasia and single copy number variant (CNV) analysis of the upstream region in SOX9 mutation negative patients, were performed. |
|
|
4. |
Novel lesions surrounding SOX9 support the existence of tissue specific enhancers acting over a large distance to regulate expression of the gene during craniofacial development. [review] |
|
|
5. |
the osmotic environment regulated both SOX9 and COL2A1 mRNA posttranscriptionally, but in fresh cells resulted in increased SOX9, but decreased COL2A1. |
|
|
6. |
Results show that the expression of PKCalpha in proliferating intestinal epithelial cells is repressed both in vitro and in vivo by the SOX9 transcription factor. |
|
|
7. |
Our data suggest that lesions affecting SOX9 expression are the key factor in sex determination in SRY-negative XX males |
|
|
8. |
Smad3 stimulated the Sox9-mediated transcription in a TGF-beta-dependent manner. |
|
|
9. |
Increased expression of SOX9 is associated with hypertrichosis. |
|
|
10. |
Sox9 gene may play a role in the process of natural degeneration of endplate chondrocytes. |
|
|
11. |
SOX9 and SOX10 but not BRN2 seem to be required for nestin expression in human melanoma. |
|
|
12. |
Some cases of Pierre Robin sequence may thus result from developmental misexpression of SOX9 due to disruption of very-long-range cis-regulatory elements. |
|
|
13. |
expression of Sox1, Sox2 and Sox9 was detected at the mRNA level in both foetal and adult cerebellum samples; Sox1, Sox2 and Sox9 expression was detected in the Purkinje cell layer of the adult cerebellum |
|
|
14. |
SOX-9 is not useful in the chordoma-chondrosarcoma differential diagnosis |
|
|
15. |
Prostaglandin D synthase-mediated SOX-9 upregulation could provide a reasonable explanation for the presence of testicular differentiation in ovarian ovarian sex cord-stromal tumours. |
|
|
16. |
Sox9 proteins are exclusively expressed in the cytoplasmic compartment in solid pseudopapillary tumours |
|
|
17. |
CEACAM1 is a direct target of SOX9 in the colon epithelium |
|
|
18. |
study confirmed SOX9 upregulation in colorectal cancer compared with normal mucosa; immunostaining showed more SOX9+ cells in lower zone of colonic crypts than upper zone; cancers with strong SOX9 immunostaining were associated with lower 5-year survival |
|
|
19. |
SOX9 expression was predictive for favorable outcome in ependymoma |
|
|
20. |
p54nrb plays an important role in the regulation of Sox9 function and the formation of paraspeckle bodies during chondrogenesis |
|
|
21. |
Sox-9, ER81 and VE-cadherin have roles in retinoic acid-mediated trans-differentiation of breast cancer cells |
|
|
22. |
Data show SOX9 transduction in chondrocytes increased their chondroitin sulfate synthetic capacity, but this was not accompanied by changes in the transcription of the CS biosynthetic enzymes. |
|
|
23. |
Critical levels of WT1 + KTS, SRY and SOX9 are required for normal Sertoli cell maturation, and subsequent normal spermatogenesis. |
|
|
24. |
Quantitative changes of enteric glia represented by SOX9 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut. |
|
|
25. |
Role of the SOX transcription factor family in adult human cartilage is most probably restricted to a few members, with SOX9 being the most prominent. |
|
|
26. |
negative regulation of claudin 7 seems to be defective in CRC, possibly due to decreased Sox-9 activity |
|
|
27. |
SOX9 has a role in mediating extracellular matrix deposition characteristic of organ fibrosis |
|
|
28. |
These findings implicate a mutation at a sex-determining locus other than SRY and SOX9 as the cause for the XX sex reversal trait in this family. |
|
|
29. |
The expression of genes in a human chondrosarcoma cell line is altered following SOX9 overexpression. |
|
|
30. |
Results support important functions of SOX9 in both the development and maintenance of normal prostate, and indicate that these functions contribute to PCa tumor growth and invasion. |
|
|
31. |
new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha |
|
|
32. |
SOX9 expression is a general feature of basal cell carcinomas and adnexal skin neoplasms, suggesting a contribution of SOX9 to the pathogenesis of these tumors. |
|
|
33. |
The association of SOX9 hypermethylation with tumour progression and clinical outcome suggests its relevant clinical implications at stratifying patients affected with bladder cancer. |
|
|
34. |
Observational study of gene-disease association. (HuGE Navigator) |
|
|
35. |
SOX9 signaling is not essential for LE135-induced chondrogenesis in mesenchymal stem cells derived from osteoarthritis patients. |
|
|
36. |
The embryonic male prostaglandin D synthase (Pgds)/SOX9 pathway is expressed at both the RNA and protein levels in different types of human ovarian tumors. |
|
|
37. |
role of SOX9 in pigmentation emphasizes the impact of SOX proteins in adult tissues. |
|
|
38. |
Sox9 transcriptionally regulates furin expression during chondrogenesis. |
|
|
39. |
A chromosomally normal boy with ACD and his clinical follow-up up to the age of 2 years, in whom a heterozygous SOX9 missense mutation (H165Y) was identified. |
|
|
40. |
Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia |
|
|
41. |
SOX9 is a key regulator of CRTL1 |
|
|
42. |
SOX9 may play an important role in the transcriptional activation of the newest collagen gene, COL27A1. |
|
|
43. |
These findings suggest that non-syndromic PRS may be caused by both SOX9 and KCNJ2 dysregulation. |
|
|
44. |
no positive correlation between SOX9 and COL2A1 expression was observed in articular chondrocytes--to the contrary, the expression of COL2A1 was significantly increased in the diseased cells |
|
|
45. |
The SOX9, as a potential melanogenic transcriptional regulator, as its expression level is increased following the down-regulation of BRN2 in differentiated melanoblasts. |
|
|
46. |
SOX9 exerts a bifunctional effect on COL2A1 gene expression in chondrocytes depending on the differentiation state. |
|
|
47. |
the ubiquitin-proteasome proteolytic system degrades Sox9 and regulates its transcriptional activity |
|
|
48. |
Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment |
|
|
49. |
Transcription factor SOX9 down-regulates CEA gene expression and, as a probable consequence, induces apoptosis in the human colon carcinoma cell line HT29Cl.16E. |
|
|
50. |
Sox9 is variably expressed in ovarian Sertoli cell tumor and other tumors that are in the differential diagnosis |
|
|
51. |
novel potential role for SOX9 in pancreas development during human embryogenesis and early foetal life |
|
|
52. |
mesenchymal chondrosarcoma showed positive nuclear staining in both primitive mesenchymal and cartilaginous components for Sox9 protein |
|
|
53. |
It is revealed with an in vitro sumoylated Ad4BP/SF-1 that DNA binding activity and interaction with Sox9 ware unaffected. |
|
|
54. |
Sox9 and p300 interact with chromatin and activates transcription via regulation of chromatin modification |
|
|
55. |
Results indicate that SOX9 in prostate basal cells supports the development and maintenance of the luminal epithelium and that a subset of prostate cancer cells may escape basal cell requirements through SOX9 expression. |
|
|
56. |
data support a direct molecular link between the Hh signaling pathway and SOX9 regulation, wherein SHH stimulates SOX9 through its mediator GLI1, and are consistent with a mechanism of SOX9 regulation through distal chromatin interactions |
|
|
57. |
by controlling the cellular concentrations of SOX9, PIAS proteins and sumoylation may be part of a major regulatory system of SOX9 functions |
|
|
58. |
Sequence analysis of the intergenic regions revealed five regulatory elements, E1-E5, 5' to SOX9 and three such elements, E6-E8, 3' to SOX9. |
|
|
59. |
Sox9 promoter is regulated by CCAAT-binding factor through its interaction with two functional CCAAT boxes. |
|
|
60. |
RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. |
|
|
61. |
demonstration that a novel human gene, KIAA0800, is preferentially expressed in the testis and is transactivated by Sox9 |
|
|
62. |
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes |
|
|
63. |
Results suggest that SOX9 is necessary and sufficient to specify pyloric sphincter epithelial properties. |
|
|
64. |
discussion of molecular action (REVIEW) |
|
|
65. |
CBP and p300 function as co-activators of Sox9 for cartilage tissue-specific gene expression and chondrocyte differentiation. |
|
|
66. |
SOX9 contributes to growth regulation by mac25 via inhibition of cell growth and promotion of differentiation in prostate tumor |
|
|
67. |
Human SOX9 in undifferentiated mouse ES cells might have dual potentials to induce both chondrogenic commitment and growth capacity in the undifferentiated status. |
|
|
68. |
pediatric and adult high grade tumors display strong nuclear staining for SOX9 |
|
|
69. |
SOX9 mRNA regulation in human articular chondrocytes involves p38 MAPK activation and mRNA stabilization |
|
|
70. |
Here we report that the human SOX9 proximal promoter is also regulated by the cyclic-AMP response element binding protein (CREB) and Sp1. |