- Official
Symbol
- MANFprovided by HGNC
- Official
Full Name
- mesencephalic astrocyte-derived neurotrophic factorprovided by HGNC
- Primary source
-
HGNC:15461
- See related
-
Ensembl:ENSG00000145050;
HPRD:03558;
MIM:601916
- Gene type
- protein coding
- RefSeq status
- REVIEWED
- Organism
-
Homo sapiens
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
- Also known as
- ARP; ARMET; MGC142148; MGC142150; MANF
- Summary
- The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon. [provided by RefSeq]
chromosome: 3;Â?Location: 3p21.1See MANF in MapViewer
Related Articles in PubMed
GeneRIFs: Gene References Into Function
What's a GeneRIF?
|
1. |
The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types. |
|
|
2. |
structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain |
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3. |
Armet is a novel secreted mediator of the adaptive pathway of unfolded protein response. |
Gene Ontology Provided by GOA
- Preferred Names
- mesencephalic astrocyte-derived neurotrophic factor
- Names
- mesencephalic astrocyte-derived neurotrophic factor
- arginine-rich protein
- arginine-rich, mutated in early stage tumors
Gene LinkOut
The following LinkOut resources are supplied by external providers. These providers are
responsible for maintaining the links.
- Molecular Biology Databases
- Research Materials
NITE Biological Resource Center- ExactAntigen
- Harvard Institute of Proteomics