Tau Neuronal pathology:

Pick's Disease Pathology
Pick Bodies

(PiD) is one of the frontal lobar dementias, primarily characterized by the presence of distinct argyrophilic (silver staining) spherical inclusions called Pick bodies and globose neurons.

The Pick body is composed of numerous tau fibrils arranged in a disorderly array (Marayama, et. al., 1990; Takauchi, et. al., 1984).  Tau protein is a major component of the Pick body, but numerous other antibodies also stain Pick bodies, including those to ubiquitin, alpha-synuclein, and apolipoprotein E.
While Pick bodies are primarily found in neurons, small, Pick-body like inclusions have been described in glial cells (Komori, 1999).

Page written by Michelle E. King
Photos by Michelle E. King