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Bigger is better when it comes to the G spot

Drugs such as Viagra should work for some women - especially if they have a big G spot. This spot, famed for producing spectacular orgasms, turns out to be awash with the enzymes that these drugs act on.

The term G spot, coined by Ernest Gräfenberg in 1950, refers to an area a few centimetres up inside the vagina on the side closest to a woman's stomach (see diagram). Buried in the flesh here are the Skene's glands, the female equivalent of the prostate gland.

In men, the prostate produces the watery component of semen. In women, Skene's glands are also thought to produce a watery substance that may explain female "ejaculation". The tissue surrounding these glands, which includes the part of the clitoris that reaches up inside the vagina, swells with blood during sexual arousal. And there's some evidence that nerves in the area produce an orgasm different to one produced by clitoral stimulation.

Nevertheless, there is still debate about whether the G spot even exists. "Not everyone has accepted this yet," says Beverly Whipple, a neurophysiologist who co-wrote a book about the G spot in the 1980s. So Emmanuele Jannini of the University of Aquila, Italy, and his team decided to look for biochemical markers of sexual function in the area where the G spot is meant to be. They picked PDE5, an enzyme that chews up the nitric oxide that triggers erections. Viagra works by blocking PDE5.

Researchers had seen evidence of nitric oxide activity in the clitoris before, but no one had actually looked for PDE5 enzymes or knew exactly where they might be. "It's ridiculous but true that we've waited till now to really know the female anatomy," says Jannini.

Anatomically impossible

He found PDE5 in the vagina of five volunteers, he will report in Adult Urology. Dissections of 14 cadavers revealed that the enzymes were mostly clustered in the G spot. But in two of the subjects with much lower concentrations of PDE5, he couldn't find any Skene's glands at all. "For such women, having a vaginal orgasm is anatomically impossible," he says.

Whipple and others suspect the glands may have been there but were too small to spot. Even so, the small size of the area should make a "G-spot orgasm" unlikely.

The findings suggest that Viagra and related drugs like tadalafil and vardenafil, set to hit the market in a few months, should have the greatest effect on women who have large Skene's glands and heaps of PDE5. Trials of Viagra in women have so far had mixed results. Some researchers speculate that this is because the women tested had too broad a range of sexual problems, from not reaching orgasm to not wanting sex at all. Jannini's work suggests that a woman's anatomy might also make a difference.

Well hidden

"Research in women using these drugs has been hampered by a lack of a framework demonstrating the biochemical processes governing the female sexual response," says Helen O'Connell of the Royal Melbourne Hospital, Australia, who showed in 1998 that the clitoris is far bigger than anyone thought. "That understanding of the clitoral and vaginal structure and function is developing is great for women."

So how do you tell if you've got a G spot? Sadly, because Skene's glands are so well hidden by the surrounding tissue, no visual examination can reveal if a women has them or not. Only personal experience can do the trick.

But even for those with a small G spot or none at all, Viagra-type drugs might still have some effect, as PDE5 is found in the clitoris too. And other drugs that stimulate arousal via the brain could soon become available. But Jannini and Whipple both agree that the female orgasm is so complex that drugs alone won't work for everyone.

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G Spot

Mon Nov 12 20:31:02 GMT 2007 by Linda Bush

I would like to knlw if there is any research going on in the Bournemouth Dorset areas of England? If there is I would be interested in helping.

Bigger Is Better

Wed Nov 14 11:17:41 GMT 2007 by Sijmons

Like the famous Kyboe watches ?

So What Is The Remedy

Thu Nov 22 13:49:06 GMT 2007 by Charles

So what is the remedy for people with small penis who cant go so deep,any hope of a happy sex life?i really want to know as i am affected.please reply asap

So What Is The Remedy

Mon Dec 03 22:01:17 GMT 2007 by Skene

To hit the G spot you only need to be just a few centimeters long so there is hope for all!

So What Is The Remedy

Fri Feb 01 09:27:12 GMT 2008 by Shriti

I have never experienced anything like it, what can we do?

This comment breached our terms of use and has been removed.

So What Is The Remedy

Wed Jan 23 06:52:07 GMT 2008 by Joy Jones

There are so many ways to experience sex, other than the size of a penis. My man is more than enough but can't manke it happen. He makes everything happen with his hands - after that - it doesn't matter about the size because you'll be so turned on, you'll both be turned on.

So What Is The Remedy

Wed Apr 01 21:00:33 BST 2009 by wherlybird

It amazes me that an article and discussion about the anatomy of an additional female orgasm center, its possible anatomy and that it seemingly doesn't even exist (at least at "functional size") in many women turns into yet another discussion to make a man, who feels inadequate about his penis size, feel better about his ability to perform or please his lover!!! All you men imagine for a moment that your penis is a mere 1% of its current size. Then imagine that this tiny version of your penis has 1000 times the nerve endings that it did originally. Then imagine that it's tucked among other sensitive tissue that somewhat conceals its location and importance. None of you can truthfully tell me that you wouldn't be shouting out where it is and for your lovers to TOUCH IT, for crying out loud! To pay attention to it, learn all there is to know about it, admire it, perhaps even worship it!!! Well, this is what we women have, the clitoris, and it's RIGHT THERE!!! While you'all are obsessing about the possible existance of the G-spot and vaginal orgasms - which simply don't happen for the majority of us regardless of penis size - and whether your penis can bring about this elusive orgasm, we've been telling you for years what reliably brings us to orgasm: clitoral stimulation, especially through you giving us pleasure orally! Cripes! Can you hear us now???? You don't need a big penis, you can be a para/quadriplegic, you can have untreated erectile dysfunction, hell - lesbians don't need a penis in the mix at all. Stop obsessing about yourself and your perceived physical inadequacies! The only inadequacy that interferes with a fantastic sex life is your refusal to be selfless, to learn about female anatomy and listen to what we're ALL telling you.

Imagine, again, that tiny penis with its vast number of nerve endings per square cm. Now, from here on out, remember that's what we women are unpretentiously walking around with every day.

So What Is The Remedy

Tue Oct 27 11:12:16 GMT 2009 by Joy

You said it and I totally agree, all these men obsess about the size of what they have- they dont realize that what matters is what you do with it!!! I have found more pleasure in my life than I have ever known with a paraplegic man who is unable to get an erection.Oral and manual stimulation give the man much more control and he can feel where he is to better make me achieve orgasm. And bonus-- he will be able to find it again easier next time!

So What Is The Remedy

Sat Jan 09 03:12:17 GMT 2010 by edward

I think you have it wrong. There are many men who would love for women to open up, and tell them what they want or need. These men would be more than willing to comply. So stop obsessing about yourself, and let men see and talk openly. Why do many women hide and don't want to talk about there vaginas but love to talk against men and their penises. So put the blame where it is due on women themselves. Especially when there are men who would love to learn? So open up!

So What Is The Remedy

Tue Mar 18 11:51:04 GMT 2008 by Catherine

Please don't forget there is always clit stimulation and you should not worry on your size as i find size does not matter it's how you feel at the moment that counts also there is also oral just to get her in the mood before clit stimulation and making love actually happens. Chin up babe x

So What Is The Remedy

Sat Apr 26 15:46:51 BST 2008 by Mighty Aphrodite

Charles, the most sensitive part of the vagina is the first 2 inches, HONESTLY. In my opinion people use deep thrusting to make up for lack of delicate sensation. You can get the same stimulation from light to moderate spanking (provides vibratory stimlulation) as from deep penetration, unless a woman just likes that pain of it. Also a woman can orgasm both ways without any penile penetration if you learn. And lastly if she has to have more, once you have learned how to be a good lover, then be comfortable in offering to use a dildo for her pleasure. However if you and she can have great climaxes without deep penetration, it may not matter at all.

Personally I really like a small/medium penis best!

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The elusive G spot: where it is - if you've got one

The elusive G spot: where it is - if you've got one

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