7. Family Guy

Original Air Date: 1999-2002 & 2005-Present
Network: FOX

This reminds me of the time IGN was making a Top 100 Animated Series list and didn't give Family Guy #1. Yeah, that happened, but you can't complain with making the Top 10. Surpassing animated comedies such as Futurama, The Flintstones and Scooby-Doo Where Are You! is a hell of a feat and Family Guy guru Seth MacFarlane deserves all the credit in the world for making it happen.

Kicking off strong after the 1999 Super Bowl, MacFarlane's wildly popular series about a dysfunctional family and their wacky misadventures would eventually prove its power by being cancelled and coming back even stronger than before. Now a major comedy presence, Family Guy has gone from tangentially making reference to other programs (in their "manatee gags") to now being lampooned and referenced itself. And the show deserves it, as we can't think of another TV comedy that creates as many laughs in a half hour as Peter Griffin and the rest of Quahog.