A penalty in either half from Rickie Lambert secured Saints a first home success in the league this season.
The game between the two south coast teams was a hotly contested affair, which Nigel Adkins' men ran out comfortable winners in thanks largely to the spot kicks awarded at each end.
Lambert ended a six league game goal drought in style after earning a penalty himself and smashing his first effort from 12 yards down the middle giving Bournemouth 'keeper Shwan Jalal no chance of saving it.
The Liverpudlian's second arrived after Morgan Schneiderlin was floored by Cherries midfielder Marvin Bartley ten minutes into the second half, and this time, the forward struck home into the bottom left corner in front of the Northam End.
The victory was compounded for the visitors when they were reduced to ten men late on as defender Adam Smith saw red for a second booking.
Saints: Davis, Butterfield, Seaborne, Fonte, Harding, Puncheon, Schneiderlin, Hammond, Lallana (Chamberlain 70), Barnard (Chaplow 79), Lambert (Guly 84). Subs (not used): Bialkowski, Dickson, Jaidi, Holmes.
Bournemouth: Jalal, Smith, Garry, Pearce, Wiggins, Bartley (Hollands 61), Feeney (Cooper 46), Robinson, Pugh, Symes (Fletcher 67), McQuoid. Subs (not used): Stewart, Cummings, Bradbury, Taylor.
Referee: Mr. K. Wright (Cambridgeshire)
Attendance: 26, 289 (including 3,268 away)
José Fonte returned to the starting line up in place of Radhi Jaidi from midweek. Adam Lallana also came in from the start for the first time since the win at Bristol Rovers in August.
Richard Chaplow took a place on the bench following his return to the club on loan from Preston North End.
Saints got the game started attacking the Chapel End on a mild day inside St. Mary's with an electric atmosphere inside the stadium, and a pulsating opening tempo to the game to match.
It was the visitors who delivered the first warning shot, as the Cherries almost registered a goal in the opening minute of play in front of the visiting support. Michael Symes laid the ball into the path into the path of Liam Feeney, and the midfielder smashed a shot on to the post, and from the follow up, Symes passed an effort narrowly wide of the far post.
Two minutes later at the other end, former Cherry Adam Lallana fed the ball though to Lee Barnard who drew a terrific one handed save from Shwan Jalal, and the follow up from Rickie Lambert inside six yards was blocked out for a corner.
The resulting corner saw Dean Hammond's header held by Jalal on his goal line.
Lallana went close with a spectacular effort in the seventh minute as he acrobatically connected to Barnard's cross from the right with an overhead kick, which flew just wide of the far post at the Chapel End.
On 11 Lambert flashed a header from Puncheon's corner wide, and moments later the two combined again with the roles reversed as the winger struck a shot over Jalal's from just inside the area.
Saints were then awarded a penalty when Rhoys Wiggins hauled down LAMBERT, and the striker stepped up himself to smash home down the centre of the goal to give the hosts the lead on 18 minutes.
After the dust had settled, the game remained fiercely competitive in midfield. Morgan Schneiderlin was given a warning by the referee after a late challenge on Marvin Bartley in the middle of the park.
Hammond was the next Saint to try his luck from the edge of the area, but the team skipper was put off at the last minutes as he went to pull the trigger, which saw his shot drag across the surface and out into touch.
Referee Mr. Wright looked in the wrong after pulling play back for a foul as Jason Puncheon bore down on goal. Cherries captain Jason Pearce was cautioned for the infringement, but the St. Mary's faithful were frustrated to see the match official call the ball back.
A free-kick at the end of the half from the Cherries failed to test the hosts as Saints went into the interval with their lead still intact.
Half Time: Saints 1-0 AFC Bournemouth
At the break Bournemouth replaced Liam Feeney with Shaun Cooper before they got the new half underway.
An initial slow start to the new half was interrupted by an incredible series of last ditch blocks from Jalal as he saved at the feet of Barnard from Puncheon's cross, before Lambert, Lallana and then Schneiderlin were also denied. However, the Frenchman was shoved in the back by Bartley as he tried to find a way past the 'keeper, leaving the referee with no other option than to award a second penalty of the game to the hosts.
LAMBERT stepped up again and unerringly slammed home the spot kick into the bottom left hand corner sending Jalal the wrong way to double Saints' advantage in the 56th minute.
The Cherries brought on Danny Hollands for Bartley in midfield just past the hour mark, as the visitors sought a way back into the match. Half time substitute Shaun Cooper struck just wide of Kelvin Davis' goal with a dipping shot shortly after the visitors' second switch.
In the 64th minute Danny Butterfield warmed Jalal's hands with a firm shot from the edge of the area after Fonte had diverted a corner into the full back's path, which invited his former Crystal Palace teammate to shoot.
Adam Smith's foul on Dan Harding on the by-line in front of the Northam earned the Bournemouth defender a booking, before boss Eddie Howe made his final substitution with experienced striker Steve Fletcher replacing Michael Symes in attack.
Nigel Adkins made his first switch two minutes later as Lallana completed a 70 minute shift on his return to the starting eleven with Alex Chamberlain taking his place on the right for the remainder of the game.
On 72 Barnard was fouled as he received Harding's defence splitting pass, and the referee gave a free-kick to the hosts 20 yards from goal. Eyeing up a hat-trick Lambert struck a vicious curled effort over the wall and on target which Jalal had to parry to safety.
Inside the last quarter of an hour Marc Pugh's deflected shot earned the visitors a corner and from the resulting set piece, the Cherries felt that they should have been awarded a penalty of their own as Fletcher was tugged back.
Richard Chaplow marked his return to St. Mary's by replacing Barnard for the last eleven minutes or so, having put in another hard working shift in up front.
Saints' final change saw Guly introduced for Lambert with six minutes remaining.
It got worse for the visitors two minutes later as Bournemouth's on loan defender Adam Smith received his second booking of the match reducing the Cherries to ten men for the closing stages.
Chaplow received a yellow card for his foul on Pearce, and Jalal followed the Saints midfielder into the book retrospectively before three minutes of additional time were added on.
Guly flashed a shot wide as a third looked on the cards, but moments later the final whistle arrived to seal an important home win.
Full Time: Saints 2-0 Bournemouth