Geraldine Seydoux, Ph.D.Image

Professor of Molecular Biology and Genetics

Investigator of Howard Hughes Medical Institute

Contact Information

Room 706, Preclinical Teaching Building
410-614-4622; 410-614-4623
410-552-6718 (Fax)
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Link to Prof. Seydoux' Lab Page

Research Interests

EMBRYONIC POLARITY AND THE SOMA-GERMLINE DICHOTOMY

Our lab studies the earliest stages of embryogenesis to understand how single-celled eggs develop into complex multicellular embryos. We focus on the choice between soma and germline, one of the first developmental decisions faced by embryos. Our goal is to identify and characterize the molecular mechanisms that activate embryonic development, polarize embryos, and distinguish between somatic and germline cells. We use genetic, molecular and biochemical techniques and use the Caenorhabditis elegans as a model system. For more information, see papers below and the Seydoux lab website http://www.bs.jhmi.edu/MBG/SeydouxLab.

Selected Publications

Voronina, E, Seydoux, G (2010), The nucleoporin NPP-10/Nup98 is required for
the integrity and function of germline P granules. Development 137,
1441-1450.

Cheng K. , Klancer R. , Singson A, and Seydoux G. (2009) Regulation of
MBK-2/DYRK by CDK-1 and the pseudo-phosphatases EGG-4 and EGG-5 during the
oocyte-to-embryo transition. Cell, 139(3):560-72.

Merritt C., Rasoloson D., Ko D., Seydoux G (2008). 3ยน UTRs are the primary
regulators of gene expression in the C. elegans germline. Current Biology,
18(19):1476-82.

Stitzel, M. and Seydoux, G (2007). Regulation of the oocyte-to-zygote
transition. Science 316, 407-8.

Seydoux, G and Braun, R. (2006). Pathway to totipotency: lessons from germ
cells. Cell 127, 891-904.
 
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