Report on Carcinogens

12th Report on Carcinogens

http://ntp.niehs.nih.gov/go/roc12
12th Report on Carcinogens U.S. Department of Health and Human Services Secretary Kathleen Sebelius released the 12th Report on Carcinogens on June 10, 2011. (Press Release)

The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health document that is prepared for the HHS Secretary by the National Toxicology Program.

The report identifies agents, substances, mixtures, and exposure circumstances that are known or reasonably anticipated to cause cancer in humans.


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Newly reviewed substances in the 12th RoC

Aristolochic acids

Certain glass wool fibers (inhalable)

Cobalt-tungsten carbide: powders and hard metals

12th RoC document

Access Report Contents
  1. Introduction and the Report on Carcinogens Review Process
    1. IntroductionDownload Adobe Acrobat Reader to open this document(150KB)
    2. NTP Report on Carcinogens Review ProcessDownload Adobe Acrobat Reader to open this document(310KB)
  2. Substances Listed in the Twelfth Report on Carcinogens
    1. Listing Status
      1. Known To Be Human CarcinogensDownload Adobe Acrobat Reader to open this document(68KB)
      2. Reasonably Anticipated To Be Human CarcinogensDownload Adobe Acrobat Reader to open this document(87KB)
    2. Substance Profiles
      1. AcetaldehydeDownload Adobe Acrobat Reader to open this document(124KB)
      2. 2-AcetylaminofluoreneDownload Adobe Acrobat Reader to open this document(90KB)
      3. AcrylamideDownload Adobe Acrobat Reader to open this document(115KB)
      4. AcrylonitrileDownload Adobe Acrobat Reader to open this document(106KB)
      5. AdriamycinDownload Adobe Acrobat Reader to open this document(90KB)
      6. AflatoxinsDownload Adobe Acrobat Reader to open this document(103KB)
      7. Alcoholic Beverage ConsumptionDownload Adobe Acrobat Reader to open this document(83KB)
      8. 2-AminoanthraquinoneDownload Adobe Acrobat Reader to open this document(109KB)
      9. o-AminoazotolueneDownload Adobe Acrobat Reader to open this document(82KB)
      10. 4-AminobiphenylDownload Adobe Acrobat Reader to open this document(141KB)
      11. 1-Amino-2,4-dibromoanthraquinoneDownload Adobe Acrobat Reader to open this document(92KB)
      12. 1-Amino-2-methylanthraquinoneDownload Adobe Acrobat Reader to open this document(108KB)
      13. AmitroleDownload Adobe Acrobat Reader to open this document(137KB)
      14. o-Anisidine and Its HydrochlorideDownload Adobe Acrobat Reader to open this document(108KB)
      15. Aristolochic AcidsDownload Adobe Acrobat Reader to open this document(216KB)
      16. Arsenic and Inorganic Arsenic CompoundsDownload Adobe Acrobat Reader to open this document(109KB)
      17. AsbestosDownload Adobe Acrobat Reader to open this document(107KB)
      18. AzacitidineDownload Adobe Acrobat Reader to open this document(96KB)
      19. AzathioprineDownload Adobe Acrobat Reader to open this document(87KB)
      20. Basic Red 9 MonohydrochlorideDownload Adobe Acrobat Reader to open this document(102KB)
      21. BenzeneDownload Adobe Acrobat Reader to open this document(156KB)
      22. Benzidine and Dyes Metabolized to BenzidineDownload Adobe Acrobat Reader to open this document(190KB)
        1. Benzidine
        2. Dyes Metabolized to Benzidine (Benzidine Dye Class)
      23. BenzotrichlorideDownload Adobe Acrobat Reader to open this document(94KB)
      24. Beryllium and Beryllium CompoundsDownload Adobe Acrobat Reader to open this document(106KB)
      25. 2,2-Bis(bromomethyl)-1,3-propanediol (Technical Grade)Download Adobe Acrobat Reader to open this document(85KB)
      26. Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl EtherDownload Adobe Acrobat Reader to open this document(94KB)(91.66KB)
      27. BromodichloromethaneDownload Adobe Acrobat Reader to open this document(100KB)
      28. 1,3-ButadieneDownload Adobe Acrobat Reader to open this document(136KB)
      29. 1,4-Butanediol DimethanesulfonateDownload Adobe Acrobat Reader to open this document(79KB)
      30. Butylated HydroxyanisoleDownload Adobe Acrobat Reader to open this document(94KB)
      31. Cadmium and Cadmium CompoundsDownload Adobe Acrobat Reader to open this document(116KB)
      32. CaptafolDownload Adobe Acrobat Reader to open this document(201KB)
      33. Carbon TetrachlorideDownload Adobe Acrobat Reader to open this document(163KB)
      34. Ceramic Fibers (Respirable Size)Download Adobe Acrobat Reader to open this document(102KB)
      35. ChlorambucilDownload Adobe Acrobat Reader to open this document(89KB)
      36. ChloramphenicolDownload Adobe Acrobat Reader to open this document(154KB)
      37. Chlorendic AcidDownload Adobe Acrobat Reader to open this document(91KB)
      38. Chlorinated Paraffins (C12, 60% Chlorine)Download Adobe Acrobat Reader to open this document(96KB)
      39. ChloroformDownload Adobe Acrobat Reader to open this document(178KB)
      40. 3-Chloro-2-methylpropeneDownload Adobe Acrobat Reader to open this document(91KB)
      41. 4-Chloro-o-phenylenediamineDownload Adobe Acrobat Reader to open this document(115KB)
      42. ChloropreneDownload Adobe Acrobat Reader to open this document(105KB)
      43. p-Chloro-o-toluidine and Its HydrochlorideDownload Adobe Acrobat Reader to open this document(160KB)
      44. Chromium Hexavalent CompoundsDownload Adobe Acrobat Reader to open this document(136KB)
      45. CisplatinDownload Adobe Acrobat Reader to open this document(141KB)
      46. Coal Tars and Coal-Tar PitchesDownload Adobe Acrobat Reader to open this document(110KB)
      47. Cobalt SulfateDownload Adobe Acrobat Reader to open this document(148KB)
      48. CobaltTungsten Carbide: Powders and Hard MetalsDownload Adobe Acrobat Reader to open this document(175KB)
      49. Coke-Oven EmissionsDownload Adobe Acrobat Reader to open this document(88KB)
      50. p-CresidineDownload Adobe Acrobat Reader to open this document(126KB)
      51. CupferronDownload Adobe Acrobat Reader to open this document(83KB)
      52. CyclophosphamideDownload Adobe Acrobat Reader to open this document(109KB)
      53. Cyclosporin ADownload Adobe Acrobat Reader to open this document(144KB)
      54. DacarbazineDownload Adobe Acrobat Reader to open this document(128KB)
      55. DanthronDownload Adobe Acrobat Reader to open this document(128KB)
      56. 2,4-Diaminoanisole SulfateDownload Adobe Acrobat Reader to open this document(129KB)
      57. 2,4-DiaminotolueneDownload Adobe Acrobat Reader to open this document(98KB)
      58. DiazoaminobenzeneDownload Adobe Acrobat Reader to open this document(133KB)
      59. 1,2-Dibromo-3-chloropropaneDownload Adobe Acrobat Reader to open this document(140KB)
      60. 1,2-DibromoethaneDownload Adobe Acrobat Reader to open this document(117KB)
      61. 2,3-Dibromo-1-propanolDownload Adobe Acrobat Reader to open this document(123KB)
      62. 1,4-DichlorobenzeneDownload Adobe Acrobat Reader to open this document(122KB)
      63. 3,3'-Dichlorobenzidine and Its DihydrochlorideDownload Adobe Acrobat Reader to open this document(123KB)
      64. DichlorodiphenyltrichloroethaneDownload Adobe Acrobat Reader to open this document(165KB)
      65. 1,2-DichloroethaneDownload Adobe Acrobat Reader to open this document(158KB)
      66. DichloromethaneDownload Adobe Acrobat Reader to open this document(160KB)
      67. 1,3-Dichloropropene (Technical Grade)Download Adobe Acrobat Reader to open this document(125KB)
      68. DiepoxybutaneDownload Adobe Acrobat Reader to open this document(126KB)
      69. Diesel Exhaust ParticulatesDownload Adobe Acrobat Reader to open this document(116KB)
      70. Di(2-ethylhexyl) PhthalateDownload Adobe Acrobat Reader to open this document(183KB)
      71. DiethylstilbestrolDownload Adobe Acrobat Reader to open this document(162KB)
      72. Diethyl SulfateDownload Adobe Acrobat Reader to open this document(139KB)
      73. Diglycidyl Resorcinol EtherDownload Adobe Acrobat Reader to open this document(122KB)
      74. 3,3'-Dimethoxybenzidine and Dyes Metabolized to 3,3'-DimethoxybenzidineDownload Adobe Acrobat Reader to open this document(138KB)
        1. 3,3'-Dimethoxybenzidine
        2. Dyes Metabolized to 3,3'-Dimethoxybenzidine (3,3'-Dimethoxybenzidine Dye Class)
      75. 4-DimethylaminoazobenzeneDownload Adobe Acrobat Reader to open this document(139KB)
      76. 3,3'-Dimethylbenzidine and Dyes Metabolized to 3,3'-DimethylbenzidineDownload Adobe Acrobat Reader to open this document(184KB)
        1. 3,3'-Dimethylbenzidine
        2. Dyes Metabolized to 3,3'-Dimethylbenzidine (3,3'-Dimethylbenzidine Dye Class)
      77. Dimethylcarbamoyl ChlorideDownload Adobe Acrobat Reader to open this document(124KB)
      78. 1,1-DimethylhydrazineDownload Adobe Acrobat Reader to open this document(141KB)
      79. Dimethyl SulfateDownload Adobe Acrobat Reader to open this document(136KB)
      80. Dimethylvinyl ChlorideDownload Adobe Acrobat Reader to open this document(121KB)
      81. 1,4-DioxaneDownload Adobe Acrobat Reader to open this document(174KB)
      82. Disperse BlueDownload Adobe Acrobat Reader to open this document(140KB)
      83. EpichlorohydrinDownload Adobe Acrobat Reader to open this document(181KB)
      84. ErioniteDownload Adobe Acrobat Reader to open this document(87KB)
      85. Estrogens, SteroidalDownload Adobe Acrobat Reader to open this document(138KB)
      86. Ethylene OxideDownload Adobe Acrobat Reader to open this document(195KB)
      87. Ethylene ThioureaDownload Adobe Acrobat Reader to open this document(117KB)
      88. Ethyl MethanesulfonateDownload Adobe Acrobat Reader to open this document(88KB)
      89. FormaldehydeDownload Adobe Acrobat Reader to open this document(287KB) [See Addendum]
      90. FuranDownload Adobe Acrobat Reader to open this document(171KB)
      91. Certain Glass Wool Fibers (Inhalable)Download Adobe Acrobat Reader to open this document(209KB)
      92. GlycidolDownload Adobe Acrobat Reader to open this document(138KB)
      93. Hepatitis B VirusDownload Adobe Acrobat Reader to open this document(103KB)
      94. Hepatitis C VirusDownload Adobe Acrobat Reader to open this document(104KB)
      95. Heterocyclic Amines (Selected)Download Adobe Acrobat Reader to open this document(239KB)
        1. 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline
        2. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline
        3. 2-Amino-3-methylimidazo[4,5-f]quinoline
        4. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
      96. HexachlorobenzeneDownload Adobe Acrobat Reader to open this document(183KB)
      97. HexachloroethaneDownload Adobe Acrobat Reader to open this document(171KB)
      98. HexamethylphosphoramideDownload Adobe Acrobat Reader to open this document(142KB)
      99. Human Papillomaviruses: Some Genital-Mucosal TypesDownload Adobe Acrobat Reader to open this document(112KB)
      100. Hydrazine and Hydrazine SulfateDownload Adobe Acrobat Reader to open this document(175KB)
      101. HydrazobenzeneDownload Adobe Acrobat Reader to open this document(147KB)
      102. Ionizing RadiationDownload Adobe Acrobat Reader to open this document(203KB)
        1. X-Radiation and Gamma Radiation
        2. Neutrons
        3. Radon
        4. Thorium Dioxide
      103. Iron Dextran ComplexDownload Adobe Acrobat Reader to open this document(93KB)
      104. IsopreneDownload Adobe Acrobat Reader to open this document(200KB)
      105. KeponeDownload Adobe Acrobat Reader to open this document(146KB)
      106. Lead and Lead CompoundsDownload Adobe Acrobat Reader to open this document(142KB)
      107. Lindane, Hexachlorocyclohexane (Technical Grade), and Other Hexachlorocyclohexane IsomersDownload Adobe Acrobat Reader to open this document(174KB)
      108. MelphalanDownload Adobe Acrobat Reader to open this document(137KB)
      109. Methoxsalen with Ultraviolet A TherapyDownload Adobe Acrobat Reader to open this document(152KB)
      110. 2-MethylaziridineDownload Adobe Acrobat Reader to open this document(145KB)
      111. 4,4'-Methylenebis(2-chloroaniline)Download Adobe Acrobat Reader to open this document(168KB)
      112. 4,4'-Methylenebis(N,N-dimethyl)benzenamineDownload Adobe Acrobat Reader to open this document(99KB)
      113. 4,4'-Methylenedianiline and Its DihydrochlorideDownload Adobe Acrobat Reader to open this document(164KB)
      114. MethyleugenolDownload Adobe Acrobat Reader to open this document(157KB)
      115. Methyl MethanesulfonateDownload Adobe Acrobat Reader to open this document(127KB)
      116. MetronidazoleDownload Adobe Acrobat Reader to open this document(101KB)
      117. Michlers KetoneDownload Adobe Acrobat Reader to open this document(137KB)
      118. Mineral Oils: Untreated and Mildly TreatedDownload Adobe Acrobat Reader to open this document(95KB)
      119. MirexDownload Adobe Acrobat Reader to open this document(166KB)
      120. Mustard GasDownload Adobe Acrobat Reader to open this document(139KB)
      121. NaphthaleneDownload Adobe Acrobat Reader to open this document(170KB)
      122. 2-NaphthylamineDownload Adobe Acrobat Reader to open this document(148KB)
      123. Nickel Compounds and Metallic NickelDownload Adobe Acrobat Reader to open this document(137KB)
        1. Nickel Compounds
        2. Metallic Nickel
      124. Nitrilotriacetic AcidDownload Adobe Acrobat Reader to open this document(153KB)
      125. o-NitroanisoleDownload Adobe Acrobat Reader to open this document(146KB)
      126. Nitroarenes (Selected)Download Adobe Acrobat Reader to open this document(339KB)
        1. 1,6-Dinitropyrene
        2. 1,8-Dinitropyrene
        3. 6-Nitrochrysene
        4. 1-Nitropyrene
        5. 4-Nitropyrene
      127. NitrobenzeneDownload Adobe Acrobat Reader to open this document(156KB)
      128. NitrofenDownload Adobe Acrobat Reader to open this document(100KB)
      129. Nitrogen Mustard HydrochlorideDownload Adobe Acrobat Reader to open this document(151KB)
      130. NitromethaneDownload Adobe Acrobat Reader to open this document(149KB)
      131. 2-NitropropaneDownload Adobe Acrobat Reader to open this document(154KB)
      132. N-Nitrosamines: 15 ListingsDownload Adobe Acrobat Reader to open this document(445KB)
        1. N-Methyl-N'-Nitro-N-Nitrosoguanidine
        2. N-Nitrosodi-n-butylamine
        3. N-Nitrosodiethanolamine
        4. N-Nitrosodiethylamine
        5. N-Nitrosodimethylamine
        6. N-Nitrosodi-n-propylamine
        7. N-Nitroso-N-ethylurea
        8. 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
        9. N-Nitroso-N-methylurea
        10. N-Nitrosomethylvinylamine
        11. N-Nitrosomorpholine
        12. N-Nitrosonornicotine
        13. N-Nitrosopiperidine
        14. N-Nitrosopyrrolidine
        15. N-Nitrososarcosine
      133. Nitrosourea Chemotherapeutic AgentsDownload Adobe Acrobat Reader to open this document(294KB)
        1. Bis(chloroethyl) Nitrosourea
        2. 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
        3. 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea
        4. Chlorozotocin
        5. Streptozotocin
      134. o-NitrotolueneDownload Adobe Acrobat Reader to open this document(207KB)
      135. NorethisteroneDownload Adobe Acrobat Reader to open this document(146KB)
      136. Ochratoxin ADownload Adobe Acrobat Reader to open this document(182KB)
      137. 4,4'-OxydianilineDownload Adobe Acrobat Reader to open this document(149KB)
      138. OxymetholoneDownload Adobe Acrobat Reader to open this document(111KB)
      139. Phenacetin and Analgesic Mixtures Containing PhenacetinDownload Adobe Acrobat Reader to open this document(105KB)
        1. Phenacetin
        2. Analgesic Mixtures Containing Phenacetin
      140. Phenazopyridine HydrochlorideDownload Adobe Acrobat Reader to open this document(137KB)
      141. PhenolphthaleinDownload Adobe Acrobat Reader to open this document(119KB)
      142. Phenoxybenzamine HydrochlorideDownload Adobe Acrobat Reader to open this document(96KB)
      143. Phenytoin and Phenytoin SodiumDownload Adobe Acrobat Reader to open this document(210KB)
      144. Polybrominated BiphenylsDownload Adobe Acrobat Reader to open this document(169KB)
      145. Polychlorinated BiphenylsDownload Adobe Acrobat Reader to open this document(148KB)
      146. Polycyclic Aromatic Hydrocarbons: 15 ListingsDownload Adobe Acrobat Reader to open this document(218KB)
        1. Benz[a]anthracene
        2. Benzo[b]fluoranthene
        3. Benzo[j]fluoranthene
        4. Benzo[k]fluoranthene
        5. Benzo[a]pyrene
        6. Dibenz[a,h]acridine
        7. Dibenz[a,j]acridine
        8. Dibenz[a,h]anthracene
        9. 7H-Dibenzo[c,g]carbazole
        10. Dibenzo[a,e]pyrene
        11. Dibenzo[a,h]pyrene
        12. Dibenzo[a,i]pyrene
        13. Dibenzo[a,l]pyrene
        14. Indeno[1,2,3-cd]pyrene
        15. 5-Methylchrysene
      147. Procarbazine and Its HydrochlorideDownload Adobe Acrobat Reader to open this document(156KB)
      148. ProgesteroneDownload Adobe Acrobat Reader to open this document(167KB)
      149. 1,3-Propane SultoneDownload Adobe Acrobat Reader to open this document(147KB)
      150. β-PropiolactoneDownload Adobe Acrobat Reader to open this document(110KB)
      151. Propylene OxideDownload Adobe Acrobat Reader to open this document(166KB)
      152. PropylthiouracilDownload Adobe Acrobat Reader to open this document(147KB)
      153. ReserpineDownload Adobe Acrobat Reader to open this document(109KB)
      154. RiddelliineDownload Adobe Acrobat Reader to open this document(196KB)
      155. SafroleDownload Adobe Acrobat Reader to open this document(156KB)
      156. Selenium SulfideDownload Adobe Acrobat Reader to open this document(143KB)
      157. Silica, Crystalline (Respirable Size)Download Adobe Acrobat Reader to open this document(106KB)
      158. SootsDownload Adobe Acrobat Reader to open this document(88KB)
      159. Strong Inorganic Acid Mists Containing Sulfuric AcidDownload Adobe Acrobat Reader to open this document(185KB)
      160. StyreneDownload Adobe Acrobat Reader to open this document(363KB)
      161. Styrene-7,8-oxideDownload Adobe Acrobat Reader to open this document(167KB)
      162. SulfallateDownload Adobe Acrobat Reader to open this document(137KB)
      163. TamoxifenDownload Adobe Acrobat Reader to open this document(186KB)
      164. 2,3,7,8-Tetrachlorodibenzo-p-dioxinDownload Adobe Acrobat Reader to open this document(190KB)
      165. TetrachloroethyleneDownload Adobe Acrobat Reader to open this document(181KB)
      166. TetrafluoroethyleneDownload Adobe Acrobat Reader to open this document(157KB)
      167. TetranitromethaneDownload Adobe Acrobat Reader to open this document(148KB)
      168. ThioacetamideDownload Adobe Acrobat Reader to open this document(146KB)
      169. 4,4'-ThiodianilineDownload Adobe Acrobat Reader to open this document(106KB)
      170. ThiotepaDownload Adobe Acrobat Reader to open this document(150KB)
      171. ThioureaDownload Adobe Acrobat Reader to open this document(155KB)
      172. Tobacco-Related ExposuresDownload Adobe Acrobat Reader to open this document(156KB)
        1. Tobacco Smoking
        2. Environmental Tobacco Smoke
        3. SmokelessTobacco
      173. Toluene DiisocyanatesDownload Adobe Acrobat Reader to open this document(196KB)
      174. o-Toluidine and Its HydrochlorideDownload Adobe Acrobat Reader to open this document(122KB)
      175. ToxapheneDownload Adobe Acrobat Reader to open this document(123KB)
      176. TrichloroethyleneDownload Adobe Acrobat Reader to open this document(213KB)
      177. 2,4,6-TrichlorophenolDownload Adobe Acrobat Reader to open this document(174KB)
      178. 1,2,3-TrichloropropaneDownload Adobe Acrobat Reader to open this document(177KB)
      179. Tris(2,3-dibromopropyl) PhosphateDownload Adobe Acrobat Reader to open this document(159KB)
      180. Ultraviolet Radiation Related ExposuresDownload Adobe Acrobat Reader to open this document(136KB)
        1. Solar Radiation
        2. Exposure to Sunlamps or Sunbeds
        3. Broad-Spectrum UVR
        4. UVA
        5. UVB
        6. UVC
      181. UrethaneDownload Adobe Acrobat Reader to open this document(177KB)
      182. 4-Vinyl-1-cyclohexene DiepoxideDownload Adobe Acrobat Reader to open this document(149KB)
      183. Vinyl Halides (Selected)Download Adobe Acrobat Reader to open this document(166KB)
        1. Vinyl Bromide
        2. Vinyl Chloride
        3. Vinyl Fluoride
      184. Wood DustDownload Adobe Acrobat Reader to open this document(106KB)
    3. GlossaryDownload Adobe Acrobat Reader to open this document(190KB)
    4. Acronyms and AbbreviationsDownload Adobe Acrobat Reader to open this document(77KB)
    5. Units of MeasurementDownload Adobe Acrobat Reader to open this document(76KB)
  3. Appendix A: Manufacturing Processes, Occupations, and Exposure Circumstances Classified by IARC as Category 1, Carcinogenic To HumansDownload Adobe Acrobat Reader to open this document(67KB)
  4. Appendix B: Substances Delisted from the Report on CarcinogensDownload Adobe Acrobat Reader to open this document(132KB)
  5. Appendix C: Substances Reviewed but Not Recommended for Listing in the Report on CarcinogensDownload Adobe Acrobat Reader to open this document(67KB)
  6. Appendix D: List of ParticipantsDownload Adobe Acrobat Reader to open this document(117KB)
  7. Appendix E: Chemicals Nominated to the NTP in Fiscal Years 2004 to 2009 for In-Depth Toxicological EvaluationDownload Adobe Acrobat Reader to open this document(204KB)
  8. Appendix F: Substance Names and Common SynonymsDownload Adobe Acrobat Reader to open this document(165KB)
  9. Appendix G: List of Substances by CAS NumberDownload Adobe Acrobat Reader to open this document(84KB)

Addendum to the 12th RoCDownload Adobe Acrobat Reader to open this document(70KB)
Official Citation: Report on Carcinogens, Twelfth Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.

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