Overview

Our laboratory seeks to decipher how organisms regulate their growth, development and proliferation through establishing and maintaining proper homeostatic control mechanisms. We are interested in understanding how stress-responsive genes are activated and how the encoded proteins function in the prevention of disease states. We are also interested in how organisms transport and distribute the essential nutrients copper and iron, and properly regulate gene expression in response to these metals for normal growth and development. Our research investigations use yeast, fruit flies, mice and cultured human cells as model systems.