'Miracle fruit' turns sour things sweet

CANCER PATIENTS

March 25, 2009|By Madison Park CNN

The small fruit has the color of a cranberry, the shape of an almond and tastes like a flavorless gummy.

But after chewing the fruit and rubbing the pulp against the tongue, the berry, known by a promising name -- "miracle fruit" or Synsepalum dulcificum -- releases a sweetening potency that alters the taste buds.

For about 15 to 30 minutes, everything sour is sweet.

Lemons lose their zing and taste like candy. Oranges become sickeningly sweet. Hot sauce that usually burns the tongue tastes like honey barbecue sauce that scorches as it trickles down the throat.

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Through word of mouth, these miracle fruits have inspired "taste tripping" parties, where foodies and curious eaters pay $10 to $35 to try the berries, which are native to West Africa.

About five months ago, a Miami, Florida, hospital began studying whether the fruit's sweetening effects can restore the appetite of cancer patients whose chemotherapy treatments have left them with dulled taste buds.

"What happens in patients is the food tastes so metallic and bland, it becomes repulsive," said Dr. Mike Cusnir, a lead researcher on the project and oncologist at Mount Sinai Medical Center. "Most of the patients undergoing chemotherapy have weight loss. Then they cut further into their diet and then this furthers the weight loss. It causes malnutrition, decreased function of the body and electrolyte imbalance."

One of Cusnir's patients, Don Blechman, told him about the fruit after discovering it while he and his wife volunteered at a tropical fruit garden in Coral Gables, Florida.

"We didn't need it, but we thought it's wonderful and told a lot of people," said his wife, Terry Blechman. "If you can't eat because everything tastes bitter, and one berry gives you back your taste for a meal, what is it worth? It's worth everything."

Cusnir filed for an investigational new drug application, which is required by the U.S. Food and Drug Administration to use an unapproved product in a new patient population. His study seeks 40 cancer patients.

"The majority have given good feedback that it did improve taste," Cusnir said. "A few patients felt there wasn't much change. The feedback is mixed as it usually is in any situation. It's been encouraging, but we haven't analyzed the data so far."

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