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Meta-Analysis of All Published AD Association Studies (Case-Control Only) APOE_e2/3/4
Back Search Methods Disclaimer Credits
 Polymorphism: APOE_e2/3/4
 Gene: APOE_e2/3/4  (AD2 (ε2/3/4); MGC1571 (ε2/3/4); APOE (ε2/3/4))  Entrez Gene    View on ALSGene   View on MSGene   View on PDGene   View on SZGene
 Protein: apolipoprotein E (ε2/3/4)  (Alzheimer disease 2 (ε2/3/4))  ProteinLink
 Chromosome: 19   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 29 January 2010 ;  ** See APOE Methods **
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  2-Allele
(frequency)
3-Allele
(frequency)
4-Allele
(frequency)
2/2
(frequency)
2/3
(frequency)
3/3
(frequency)
2/4
(frequency)
3/4
(frequency)
4/4
(frequency)
 Caucasian 28 AD
CTR
0.04
0.08
0.59
0.78
0.38
0.14
7 (0.003)
44 (0.009)
132 (0.047)
602 (0.120)
969 (0.346)
3039 (0.606)
75 (0.027)
106 (0.021)
1210 (0.432)
1122 (0.224)
407 (0.145)
99 (0.020)
 African Descent 2 AD
CTR
0.09
0.05
0.56
0.76
0.35
0.19
2 (0.028)
1 (0.009)
8 (0.111)
10 (0.090)
23 (0.319)
62 (0.559)
1 (0.014)
0 (0.000)
26 (0.361)
34 (0.306)
12 (0.167)
4 (0.036)
 Asian 4 AD
CTR
0.02
0.05
0.70
0.86
0.28
0.09
0 (0.000)
1 (0.001)
9 (0.044)
113 (0.085)
101 (0.490)
986 (0.739)
1 (0.005)
16 (0.012)
76 (0.369)
210 (0.157)
19 (0.092)
9 (0.007)
 Hispanic 1 AD
CTR
0.06
0.03
0.71
0.85
0.24
0.12
1 (0.016)
0 (0.000)
2 (0.033)
5 (0.056)
33 (0.541)
65 (0.722)
3 (0.049)
0 (0.000)
18 (0.295)
18 (0.200)
4 (0.066)
2 (0.022)
 Other/Mixed 3 AD
CTR
0.03
0.06
0.52
0.71
0.45
0.23
0 (0.000)
1 (0.002)
21 (0.036)
49 (0.090)
148 (0.256)
270 (0.495)
15 (0.026)
16 (0.029)
284 (0.492)
189 (0.346)
109 (0.189)
21 (0.038)
Total 38 AD
CTR
0.04
0.07
0.58
0.79
0.38
0.14
10 (0.003)
47 (0.007)
172 (0.046)
779 (0.110)
1274 (0.343)
4422 (0.623)
95 (0.026)
138 (0.019)
1614 (0.434)
1573 (0.222)
551 (0.148)
135 (0.019)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism APOE_e2/3/4

Please also see disclaimer for more information on these meta-analyses.

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Genes: 695
Polymorphisms: 2973
Meta-analyses: 320
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