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A blessing in disguise, albeit a very good disguise [Sep. 30th, 2012|04:05 pm]
Scott
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Very many of my friends sing the praises of modafinil (I have not tried it myself). They say it can make you more focused, more productive, and at least temporarily remove the basic human need for sleep. It doesn't have the normal stimulant side effects of "buzz" and agitation. And it's cheap and has fewer side effects than aspirin (EDIT: it does interact with other drugs including birth control and should be used with caution if you're on anything else; thank you celandine13).

(it's really convenient that aspirin became a poster child for "safe, commonly used medication" despite having such an crazy array of potential deadly side effects. It means that whenever you want to push a new drug, you can say it has "fewer side effects than aspirin" and be pretty sure that you're right)

Despite its excellent safety profile, it is currently a Schedule IV controlled substance in the United States.

Doesn't this mean that I must be wrong about its excellent safety profile? No. See for example Gwern's research on the subject. About half the people reading this paragraph are going to say "Wait, don't the FDA and the entire decision-making apparatus of the United States government have more data and credibility than one guy with a website?" The other half of the people know Gwern.

It's also worth noting that adrafinil, a prodrug of modafinil which is strictly more dangerous because it contains all the side effects of the latter plus a risk of liver damage, is totally legal without any prescription at all. And modafinil is freely available over the counter in various countries (I think Spain and India) and they have yet to collapse into unspeakable wastelands of despair.

(actually, Spain kinda did, but it seems unrelated.)

It's also worth noting that the alternative to modafinil is using legal stimulants, like Red Bull and Four Loco. These actually are dangerous and can, for example, cause abnormal heart rhythms that kill you. We also saw a steady trickle of energy drink overusers in the psychiatric hospital, and although you probably need to have an inborn disposition for energy drinks to tip you over the edge, who knows how common such an inborn disposition really is? Modafinil is probably way safer than these totally unrestricted alternatives.

So you would think that I am going to argue that modafinil should be legalized. Or at least that the cultural stigma against using it should be relaxed. But that would be too easy. Actually, I want to argue the opposite.

Let's assume that the wildest claims of my friends are correct. Some of these friends got through medical school with relatively little damage by using modafinil to study eight or ten hours a day and skip sleep. Others are in the rationality community and use it to concentrate on their programming or mathematics work. They mostly agree with Gwern that it can be modeled as adding four hours to the day, both in the form of costlessly lost sleep and in the form of greater attention during waking hours.

Economists distinguish between positional goods and...and I can't find what the opposite of a positional good is, so let's call it an absolute good. A positional good is something where it doesn't matter exactly how much of the good you have, but only what your ranking is relative to everyone else. Superyachts are probably a positional good. I don't think anyone thinks "Man, this 100 foot yacht is crap, there isn't nearly enough room for all my yachting-related activities." They think "My neighbor has a 200 foot yacht; my 100 foot yacht looks crappy in comparison. I should build a 300 foot yacht." If the person involved had the option of destroying her neighbor's 200 foot yachts, then her 100 foot yacht would suddenly become more than enough.

An absolute good is the opposite. For example, if you're injured, you want painkillers as an absolute good. It doesn't matter whether your neighbors are getting more or less painkillers than you are, so much as that you are getting enough painkillers to take away your pain.

Except it's actually really hard to think of pure absolute goods. A lot of things I was going to put as my absolute good example don't really work, because our idea of what's acceptable is set by our friends and neighbors. In Haiti, people who had a house made of real sheet metal felt awesome, because most of their neighbors were still living in refugee tents; meanwhile in America a house made of sheet metal would be awful because everyone needs to have a McMansion; a McMansion, however, is quite sufficient. But in the postsingularity thoughtspace of 19-uvara-46-asxura, everyone has their own continent perfectly terraformed as a projection of ver innermost dreams, and someone with a McMansion feels as left-out and squalid as someone living in a sheet-metal shack in America.

The richer you are, the more your goods shift from absolute to positional; 90% of the value of a $5000 used car is its getting-you-places-ness, but 90% of the value of a $500000 Ferrari is its looking-cool-relative-to-other-cars.

Right now America and to a lesser degree other first-world countries are caught in a trap where almost all of their economic growth is funneled to the rich and upper-middle-class, who spend it on positional goods. Since all the rich people are spending it on positional goods equally, none of their relative position changes in any interesting way and all of the positional goods are useless.

Therefore in the modern era most economic growth in first-world countries is pretty useless as a direct action. There may be useful indirect actions, like advancing technology, increasing tax revenue that can be spent on useful absolute goods, and increasing the amount that flows as charity to the Third World, but the actual direct effect of economic growth is pretty close to zero.

Okay, let's go back to modafinil. Right now the FDA is pretty incompetent and doesn't enforce any of its own restrictions, so in practice anyone can get modafinil. And getting modafinil is currently very useful. If you're in medical school, and you're not doing very well, you can take some modafinil, gain a big unfair advantage over your peers, and shoot up the class rankings. If you're an executive, you can work much harder and get a promotion your friends can't. If you're a programmer, you can amaze the world with your vastly improve programming output.

But let's say the FDA restrictions on modafinil switched from "poorly enforced" to "nonexistent", and let's say that at the same time the cultural stigma against using mind-enhancing drugs went away. Now what?

Now instead of hiding their use behind vague rumors, those medical students trumpet their brilliant discovery of this new wonder drug to everyone. All medical students start taking modafinil, except maybe some with religious restrictions or something. Of course, this doesn't mean that all medical students get As all the time. It means that the medical schools make their coursework much harder, and the medical students go back to being on the cusp of failure. Except now that it's harder, it's impossible for most students to pass medical school without modafinil. So the religious people flunk out, everyone else has to work much harder, and in the end no student gains. Arguably future patients might gain from having better trained doctors, but I think this wildly overestimates the usefulness of the medical education system.

The same is true of executives. Now modafinil no longer means an easy promotion. Now all the executives start taking modafinil, and everyone has the same chance of getting promoted as before, except the religious people and the people who are allergic to modafinil and anyone who has a personal preference for getting more than three hours of sleep per night even though it's not strictly necessary.

Basically, obligations are a demon that eats up all the free time and happy things in your life. If only a few people have modafinil, they have an extra weapon against the demon. If everyone has modafinil, expectations and competition increase and so the demon becomes stronger. A new equilibrium is established in which there's more economic growth (so the rich get some more useless positional goods) but everyone gets four hours less sleep per night, plus they have to spend money on modafinil, plus the few people who can't take modafinil for one reason or another are screwed.

"But wait," you say. "Couldn't people just decide to work shorter hours and instead use the extra time they have in the day to see their family or pursue their hobbies or volunteer or do something good?"

Yes, we don't live in a totalitarian society, so that choice technically exists. Just as the choice technically exists for people to try that now. Most people earn much more than they need to live. So in theory, they have the option of working twenty-five hour weeks and spending the extra fifteen hours hiking or gardening.

But in practice, people don't. The majority of well-paying acceptable jobs demand a forty-hour work week, and most people don't have the freedom to look for the ones that don't. It costs companies less money in training and overhead to hire two people to work 40-hour weeks than four people to work 20-hour weeks, and so they will always prefer the 40-hour workers. If you want to be a prestigious doctor or lawyer or executive or whatever you have to signal your commitment by working even longer than the 40-hour Schelling point. In practice, you're working as long as the companies are legally and socially permitted to make you, which in our society is 40 hours.

If suddenly days magically get four more hours in them, then the work week will shoot up to 60 hours and stay there. People might get paid more, but the economy will adjust so that the extra money becomes necessary just to tread water, the same way it looked like people were getting paid more when women entered the work force and the family could theoretically double its income but everything adjusted. The extra economic growth will go to positional goods for the rich, and you will get 20 hours less sleep per week (granted without a corresponding decrease in restfulness), have to pay for modafinil out of your own pocket, but otherwise be in about the same position.

(couldn't the government just make a law fixing the work week at its current length thus preventing this race to the bottom and all of its unfortunate consequences? In an ideal world, yes, but the small-L libertarians would never allow it.)

So legalizing modafinil (with corresponding reduction of stigma) leads directly to you having to work four hours more every day, gain an extra item on your budget (modafinil: $1000-$3000/year), get four hours less sleep (admittedly without restfulness cost, but still unpleasant especially for a lucid dreaming hobbyist like myself), plus suffer any unknown side effects of the drug that might turn up. And for all this, you get the chance to earn money that the economy immediately siphons off and throws away on more positional goods.

Despite this I'm still not sure it would be so bad. Economic growth is a pretty powerful force, and even if most of the force is wasted there are still those small direct effects on the poor/middle class plus the indirect effects which might end up being much more powerful. And maybe the government will stand up to the libertarians and fix the work-week, or the creeping increase wouldn't be as inevitable as I think.

But compare these possible benefits of legalization to how downright optimal the current modafinil regime is.

From what two of my friends in the modafinil business have told me, it's really easy to get modafinil now - just order it online with PayPal and wait a little while for shipping. And no one ever really gets in trouble for it; Gwern's research turns up only a single case in the entire history of the US in which someone got busted for modafinil, and he speculates it was just a racist Southern court looking for some excuse to convict a poor suspicious-looking black person. This probably does not generalize to risk for the average user.

So in practice, the current regime offers no downsides to seeking modafinil. It is much more of a psychological barrier than an actual barrier. But it is an effective psychological barrier, which only a few people get across. Who?

First of all, they have to be individuals rather than institutions. A big Fortune 500 company requiring all of its employees to take modafinil probably would get busted by the FDA.

Second, they can't care too much about social stigma. There's still a stigma on stimulant use, probably carried over from some of the other stimulants which really are pretty scary (WAItW, anyone?). And of course there's a stigma on breaking the law.

Third, they have to be intelligent. Anyone without at least a little curiosity is going to do what everyone else is doing and take Red Bull or Four Loco. They're never going to find good analyses like Gwern's research, and they probably couldn't understand them even if they did. An unintelligent person won't be able to distinguish modafinil from the thousand different quack remedies that are supposed to make you "more awake!" and "give you the extra energy you need to complete your day!"

Fourth, they have to be kind of..not really anti-establishment, but at least less violently pro-establishment than usual. It's pretty hard for most people to say "Well, I guess the government is wrong about this, might as well circumvent them." But that's pretty much all the counter-culture ever does.

So: individual intelligent non-social anti-establishment people. Basically geeks. And a very specific kind of geek, too. I won't specify exactly which kind beyond that link, because internecine geek feuds always turn ugly, but I think it is pointing to a particular geek cluster.

It's hard not to be suspicious that God has planned this all along. He's basically saying "Behold, geeks, you are My chosen people, so I give unto you a major advantage over non-geeks. The hilarious part shall be that it is self-selecting; anyone who chooses to use this is the sort of person I trust to have an advantage in society. Anyone who chooses not to use it, well, they probably would just screw it up anyway."

And because these geeks remain a very small percent of the population, the problems with large-scale use don't occur. The angel Technology giveth with the right hand, but the demon Economics doesn't notice and so doesn't wake up to taketh away with the left hand. It's not that it's a win-win situation. It's that it's a win-neutral situation, which in terms of positional goods is even better.

So what does it say about me that I don't (haven't yet?) used modafinil? I'm not sure. I've always known I'm not a very good anti-establishment specific-cluster geek. Last night when a friend was explaining his theory of PCs (people who are actively doing interesting work and changing the world in such a way that things revolve around them) and NPCs (people who mostly just hang around and provide background), I might have been the only person at the table not especially convinced he was a PC.

Not that I feel any deep sense of inadequacy about this. NPCs can be pretty neat too. Schala was an NPC. If I can be as awesome as she was, I'll be pretty happy.

Oh, right. Nothing in this post should be taken as any kind of official medical endorsement of modafinil, which I have not studied in a medical context and which I am not anywhere near officially qualified to recommend or disrecommend. Nothing else in this post was more than about 60% serious, but this paragraph is entirely serious.

[EDIT: 60% serious may have been an overestimate (or we may have different scales of seriousness percent). I think the argument is correct in saying the benefits from modafinil would be much lower than most people think, but I was not entirely serious in saying they would be zero, or less than the costs. I would, with some trepidation and a high expectation of regretting it later, endorse legalizing modafinil]
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Comments:
[User Picture]From: Robin Gane-McCalla
2012-10-01 02:38 am (UTC)
Can you expand on this?

"Arguably future patients might gain from having better trained doctors, but I think this wildly overestimates the usefulness of the medical education system."

OK, so I know medical education isn't perfect, but if modafinil gives you four extra hours a day, couldn't the med schools just cram more information into those four hours? So if a med student normally works 12 hours a day, with moda they could work 16 (or 15 if they wanted an extra hour to relax), so med school could be completed in 3/4ths or 4/5ths of the time which means more doctors therefore lower prices. So you get a decent benefit in terms of quantity and I don't see why you couldn't get an increase in quality as well.

I also don't see the point of you claim:

"The same is true of executives. Now modafinil no longer means an easy promotion. Now all the executives start taking modafinil, and everyone has the same chance of getting promoted as before"

Everybody does have the same chance, but the company is more productive because everyone is working longer hours and getting more done. The company may not choose to pay their workers more for being more productive but somebody will benefit from that increased productivity.

Lastly:

"If suddenly days magically get four more hours in them, then the work week will shoot up to 60 hours and stay there."

This is quite a claim. Did coffee cause a similar extension in weekly hours worked? It might be true of a limited subset of existing businesses but I don't think that they will universally adopt it. It won't affect people who are paid by the hour and many companies today don't have time clocks or other devices to make sure you work at least 40 hours, they just want to be sure that you're getting your work done and assume it will take you around 40 hours.
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[User Picture]From: squid314
2012-10-01 03:28 am (UTC)
Yay! More doctors and lower prices! This might work in a sane economy, but the bottleneck in training doctors has nothing to do with time length of medical school and everything to do with residency being so expensive that it has to be subsidized by Congress which Congress prefers not to do. Don't tell me that there are ten million much better systems that would allow that bottleneck to be removed; I already know that. But absent one of those ten million much better systems, merely having people complete medical school more quickly is not going to ease the doctor shortage. Having people complete residency more quickly might, but residents already stay up all night, and anyway it might not since a lot of the bottleneck there is number of patients seen which is not working-hour dependent.

I am also very skeptical that our economy would allow the shortening of medical school even if it were profitable. Has it ever seemed suspicious to you that every single college major, from Latin to Art History to Mathematics to Organic Chemistry, takes exactly four years? That there's no "cram" medical school that gets it done in three, or "relaxing" medical school that gets it done in five? I don't know whether it's about federal regulations or just a Schelling point, but I find it unlikely that it would change. (does this contradict my belief that the work week would change? Maybe, except that it's in the interests of those in power to change the work week)

"Everybody does have the same chance, but the company is more productive because everyone is working longer hours and getting more done. The company may not choose to pay their workers more for being more productive but somebody will benefit from that increased productivity."

I agree. Obviously here I was talking solely about the loss of advantage to the executives themselves. The company itself can do one of a few things. First, it can keep the executives it has and hopefully be more productive with them; that would require that the marginal benefit of executive work is greater than zero, of which I am suspicious. Second, it can fire some executives and either raise profits or cut prices or both; I think either result ends up in the "slightly more positional goods" trap I mentioned.

"This is quite a claim. Did coffee cause a similar extension in weekly hours worked? It might be true of a limited subset of existing businesses but I don't think that they will universally adopt it. It won't affect people who are paid by the hour and many companies today don't have time clocks or other devices to make sure you work at least 40 hours, they just want to be sure that you're getting your work done and assume it will take you around 40 hours."

Coffee doesn't actually work. People build tolerance to it; their non-coffee baseline decreases and their with-coffee productivity becomes no greater than non-coffee drinkers. The same thing might or might not happen with modafinil.

The companies that don't have time clocks sound like amazing places to work, although from my own anecdotal experience they are not the norm. However, if they found that everyone was completing their work really easily with time to spare, there is no conceivable economic reality in which they say "Okay, wonderful, enjoy your free afternoon". They'd either fire some of the workers and redistribute their work to the rest until working hours were the same as before with greater productivity, or if the company had room to expand they'd just assign every worker some extra workload.

Edited at 2012-10-01 03:41 am (UTC)
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[User Picture]From: Robin Gane-McCalla
2012-10-01 04:11 am (UTC)
So wouldn't residents benefit more from Modafinil than anybody else then? Wouldn't the increase in accidents caused by new rounds of residents decrease if they weren't so sleep deprived? I don't see how you can argue that four additional hours a day won't offer some improvement in people learning/training to be doctors. You can argue that the effect is marginal, but there has to be an effect unless the medical establishment is completely incompetent.

As for every college major taking four years, that's simply not correct. Aside from the fact that most colleges are only in session for less than half the calendar year, there's double/triple majors and people taking extra courses during the semester and classes during the summer. There exist computer degree programs where you can get a Bacherlor's in 2.5 years, pharmacy degrees (which don't require a Bachelor's to get) take 5-8 years to complete. So the time to complete medical school could change, but schools are often slow to embrace change.

I doubt your claim that the marginal benefit of executive work is greater than zero (you don't give it any support). You also don't address the promotions which are not to an executive position (which I'd imagine is the majority of them). As for companies choosing to fire executives, why would they do that if their company is growing? You seem to be hijacked by the "managers are evil and incompetent and only care about the bottom line" meme.

Do you have a citation for your coffee claim? A brief google search reveals arguments both supporting and refuting it so it's not clear to me which side is true. There do exist genetic difference in caffeine metabolism so perhaps that plays a role in how coffee effects productivity.

As for companies and how they track time, I've had over twenty jobs and I've only punched a time clock at one of them. A few others have requested I submit hours but many of them haven't tracked time at all. I have been let out of work early on occasion because there was no more work to do. To say:

"there is no conceivable economic reality in which they say "Okay, wonderful, enjoy your free afternoon"."

is completely ridiculous, there exist many conceivable economic realities where this is true and some workers (generally the most skilled and intelligent) exist in those realities. If your company is doing well (which many companies, especially when not in a recession) and there isn't work to be done (this happens, not often but it does happen) then keeping employees around is bad policy because they'll just be bored, and firing them is worse policy because they've been doing a good job and firing competent workers is bad for moral, so a competent manager will let them go. Again, I think you've been hijacked by a "managers are evil and incompetent" meme.
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[User Picture]From: squid314
2012-10-01 04:58 am (UTC)
"So wouldn't residents benefit more from Modafinil than anybody..."

Yes, residents might benefit from modafinil (many use it already). That's a bit different from the claim that it would help increase the doctor supply.

Also, careful with those clauses like "unless the medical establishment is completely incompetent" or you might get another blog post :)

"As for every college major taking four years, that's simply not correct...."

I think you're agreeing with me, not disagreeing. You agree that it's possible to double-major or triple-major in four years, meaning that in theory it should be possible to single-major it 2 or 1.33 years. But no prestigious college does this. You can get technical degrees in that amount of time, but not a degree from Harvard or the sort of places most really want to go. As you say, schools are slow to embrace change. But this makes me think the limiting factor to getting your degree quicker isn't the absence of modafinil, it's the attitude of the schools.

"I doubt your claim that the marginal benefit of executive work is greater than zero..."

That's an interesting term - the "managers are evil and incompetent and only care about the bottom line meme". I don't believe managers are evil or incompetent. I totally believe they only care about the bottom line. That's their job and I don't hold it against them. Yes, in an emerging market where the business can keep expanding indefinitely, they would keep those extra executives on. In any other situation, they are no longer useful and can be fired to cut costs

For example, suppose a company has 20 executives earning $100K/year doing 20 executives worth of work for a total budget of $2M/year. They are perfectly happy with this and have no plans to hire, say, ten extra executives because they'd have no work for them to do. Then each executive suddenly becomes 50% more productive. Now they effectively have 30 executives worth of work. But we already agreed they don't need 30 executives. So they can fire 6 executives, still get their 20 executives worth of work done, and only pay $1.4M/year, saving $600K. Your rosy-eyed hope that they could find more work for those six executives because they are expanding is contradicted by them not being in the market for 10 extra executives to begin with. Yes, a sentimental manager might choose to keep the executives on without any work for them to do even though she loses $600K by it, just because she likes them. But very few managers are that sentimental and the ones who are eventually are driven out of business by managers who earn their company $600K more.

Obviously the same applies to non-executives.

"Do you have a citation for your coffee claim..."

It sounds like you've already found citations supporting it, and want ones that conclusively counter-refute the ones against it. I don't have one of those. I was offering this as a possible explanation for why coffee doesn't increase the work week.

"As for companies and how they track time..."

If you are anything like you were when I knew you at college, I bet you end up at pretty atypical jobs :)

I agree that some managers who don't behave as proper economical agents will purely out of sentiment let employers out early. This works only in inefficient markets. In an efficient market, if one company has a sentimental manager who lets an employee out having done 10 units of work, and another company has a nonsentimental manager who realizes that in the time the employee is contracted for they can do 15 units of work for the same pay, then the nonsentimental manager will drive the sentimental manager out of business by having 150% the productivity for the same labor costs.

I deny your assertion that I have been hijacked by anti-manager memes and counter-assert that you haven't fully absorbed how markets operate (or, more charitably, you're hoping that all markets are inefficient and full of sentimental people, which holds true in some areas but not in others, and less and less so as time goes on.)

I do, however, admit that I was understating the case for the possible usefulness of modafinil.

Edited at 2012-10-01 04:58 am (UTC)
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[User Picture]From: maniakes
2012-10-01 08:23 pm (UTC)
I did my undergrad work at Cal Poly, which is admittedly less prestigious than Harvard or Stanford, but is probably near the top of the second prestige tier for undergraduate engineering schools.

It took me just over three years to get my BS in Computer Science, which is near-optimal within the official standard policies. I probably could have gotten through faster had I been more diligent in seeking exceptions to the policies in the form of testing out of more classes and getting waivers for maximum course loads.
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[User Picture]From: Douglas Scheinberg
2012-10-01 05:06 am (UTC)
Has it ever seemed suspicious to you that every single college major, from Latin to Art History to Mathematics to Organic Chemistry, takes exactly four years? That there's no "cram" medical school that gets it done in three, or "relaxing" medical school that gets it done in five?


These schools exist. They're the same ones that normally take four years to get through; you just schedule a different number of courses than the standard curriculum calls for.
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[User Picture]From: maniakes
2012-10-01 08:18 pm (UTC)
This might work in a sane economy, but the bottleneck in training doctors has nothing to do with time length of medical school and everything to do with residency being so expensive that it has to be subsidized by Congress which Congress prefers not to do.

Why is residency so expensive? If running a residency program is a net loss before public subsidies, that implies to me that residents have negative net productivity. I'd expect ubiquitous use of Modafinil by med students and residents to improve resident productivity in two ways: 1) they learn more from classroom instruction, and thus enter residency with a higher skill level, and 2) they are capable of working long and irregular shifts during residency with less productivity loss due to stress and fatigue. Improve resident productivity significantly, and for any given level of public subsidies, the market-clearing number of residency slots should increase.
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