Papers for Journal Club

Mitchison, T., L. Evans, E. Schulze, M. Kirschner, (1986). "Sites of microtubule assembly and disassembly in the mitotic spindle." Cell 45(4): 515-27.  This classic paper provided the first solid evidence for the localization of sites to which tubulin added spindle microtubules.

Pfarr, C. M., M. Coue, P.M. Grissom, T.S. Hays, M.E. Porter, J. R. McIntosh, (1990). "Cytoplasmic dynein is localized to kinetochores during mitosis [see comments]." Nature 345(6272): 263-5. The first evidence for localization of dynein to kinetochores and related spindle structures.

Echeverri, C.J., B.M. Paschal, K.T. Vaughan, R.B. Vallee, (1996). "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis." J.Cell Biol. 132: 617-633. Discovery that a protein subunit of the dynein-associated protein complex, dynactin, can interfere with dynein action in fascinating ways.

Scholey, J. M., I. Brust-Mascher, A. Mogilner, (2003). "Cell division." Nature 422(6933): 746-52. A thoughtful review of the importance of motor action in both mitosis and cytokinesis.

Goshima, G. and R. D. Vale (2003). "The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line." J Cell Biol 162(6): 1003-16. A comprehensive analysis, using modern molecular technology, of the full complexity of motor involvement with spindle formation and function.

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