Albert Hofmann

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Albert Hofmann

Albert Hofmann in 1993
Born (1906-01-11)January 11, 1906
Baden, Switzerland
Died April 29, 2008(2008-04-29) (aged 102)
Burg im Leimental, Switzerland
Residence Switzerland
Nationality Swiss
Fields Chemist
Alma mater University of Zürich
Known for Synthesis of LSD-25

Albert Hofmann (January 11, 1906 – April 29, 2008)[1][2] was a Swiss scientist known best for being the first person to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann also was the first to isolate, synthesize, and name the principal psychedelic mushroom compounds, psilocybin and psilocin.[3] He authored more than 100 scientific articles and a number of books, including LSD: My Problem Child.[2] In 2007 he was ranked a shared first place, alongside Tim Berners-Lee, in The Telegraph's list of 100 greatest living geniuses.[4]


[edit] Life and career

Hofmann was born in Baden, Switzerland, the first of four children to factory toolmaker Adolf Hofmann and his wife Elisabeth (born Elisabeth Schenk). Owing to his father's low income, Albert's godfather paid for his education. When his father became ill, Hofmann obtained a position as a commercial apprentice in concurrence with his studies. At the age of twenty, Hofmann began his chemistry degree at the University of Zürich, finishing three years later, in 1929.[citation needed] His main interest was the chemistry of plants and animals, and he later conducted important research on the chemical structure of the common animal substance chitin, for which he received his doctorate, with distinction, in 1930.[citation needed]

Regarding his decision to pursue a career as a chemist, Hofmann provided insight during a speech he delivered to the 1996 Worlds of Consciousness Conference in Heidelberg, Germany:

"One often asks oneself what roles planning and chance play in the realization of the most important events in our lives. [...] This [career] decision was not easy for me. I had already taken a Latin matricular exam, and therefore a career in the humanities stood out most prominently in the foreground. Moreover, an artistic career was tempting. In the end, however, it was a problem of theoretical knowledge which induced me to study chemistry, which was a great surprise to all who knew me. Mystical experiences in childhood, in which Nature was altered in magical ways, had provoked questions concerning the essence of the external, material world, and chemistry was the scientific field which might afford insights into this."

[edit] Discovery of LSD

Hofmann became an employee of the pharmaceutical-chemical department of Sandoz Laboratories (now a subsidiary of Novartis), located in Basel as a co-worker with professor Jordan Jake, founder and director of the pharmaceutical department.[5] He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. His main contribution was to elucidate the chemical structure of the common nucleus of the Scilla glycosides (an active principal of Mediterranean Squill).[5] While researching lysergic acid derivatives, Hofmann first synthesized LSD on November 16, 1938.[6] The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (an analeptic) with no effects on the uterus in analogy to nikethamide (which is also a diethylamide) by introducing this moiety to lysergic acid. It was set aside for five years, until April 16, 1943, when Hofmann decided to reexamine it. While re-synthesizing LSD, he accidentally absorbed a small quantity through his fingertips [7] and fortuitously discovered its powerful effects. He described what he felt as being:

... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.[8]

[edit] Further research

It gave me an inner joy, an open mindedness, a gratefulness, open eyes and an internal sensitivity for the miracles of creation. [...] I think that in human evolution it has never been as necessary to have this substance LSD. It is just a tool to turn us into what we are supposed to be.

—Albert Hofmann, Speech on 100th birthday[9]

Hofmann, later, was to discover 4-Acetoxy-DET (4-acetoxy-N,N-diethyltryptamine), also known as ethacetin, ethylacybin, or 4-AcO-DET, a hallucinogenic tryptamine. He first synthesized 4-AcO-DET in 1958 in the Sandoz lab. Hofmann became director of the natural products department at Sandoz and continued studying hallucinogenic substances found in Mexican mushrooms and other plants used by the aboriginal people. This led to the synthesis of psilocybin, the active agent of many "magic mushrooms."[10] Hofmann also became interested in the seeds of the Mexican morning glory species Turbina corymbosa, the seeds of which are called Ololiuhqui by the natives. He was surprised to find the active compound of Ololiuhqui, ergine (LSA, lysergic acid amide), to be closely related to LSD.

In 1962, he and his wife Anita Hofmann (born Guanella, sister of Gustav Guanella, an important Swiss inventor) traveled to southern Mexico to search for the plant "Ska Maria Pastora" (Leaves of Mary the Shepherdess), later known as Salvia divinorum. He was able to obtain samples of this plant, but never succeeded in identifying its active compound, which has since been identified as the diterpenoid Salvinorin A.

Albert Hofmann in 2006

In 1963, Hofmann attended the annual convention of the World Academy of Arts and Sciences (WAAS) in Stockholm.

The Swiss Federal Institute of Technology (ETH Zurich) honored him with the title D.Sc. (honoris causa) in 1969 together with Gustav Guanella, his brother-in-law.

Hofmann, interviewed shortly before his hundredth birthday, called LSD "medicine for the soul" and was frustrated by the worldwide prohibition of it. "It was used very successfully for ten years in psychoanalysis," he said, adding that the drug was misused by the Counterculture of the 1960s, and then criticized unfairly by the political establishment of the day. He conceded that it could be dangerous if misused, because a relatively high dose of 500 microgrammes will have an extremely powerful psychoactive effect, especially if administered to a first-time user without adequate supervision.[11]

In December 2007, Swiss medical authorities permitted psychotherapist Peter Gasser to perform psychotherapeutic experiments with patients who suffer from terminal-stage cancer and other deadly diseases. Although not yet started, these experiments will represent the first study of the therapeutic effects of LSD on humans in 35 years, as other studies have focused on the drug's effects on consciousness and body. Hofmann acclaimed the study, and continued to say he believed in the therapeutic benefits of LSD.[12] In 2008, Hofmann wrote Steve Jobs, asking him to support this research; it is not known if Jobs responded.[13]

Hofmann was due to speak at the World Psychedelic Forum[14] from March 21 to March 24, 2008, but was forced to cancel because of bad health.

[edit] Death

Hofmann died of natural causes on April 29, 2008, in the village of Burg im Leimental, near Basel, Switzerland. He was 102 years old.[15][16][17]

[edit] Books

In 1979 Hofmann co-authored "Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers" with Richard Evans Schultes, the father of modern ethnobotany. Albert Hofmann's autobiographical account of his experience with LSD was published in LSD: My Problem Child (1980). Hofmann also co-authored The Road to Eleusis: Unveiling the Secret of the Mysteries (Hermes Press, 1998, North Atlantic Books, 2008), a collaborative effort with mycologist R. Gordon Wasson, and classical scholars Carl Ruck and Blaise Staples, which investigates the secret mystic elixir that was a component of the Eleusinian Mysteries. Hofmann further describes the relevance of the Eleusinian Mysteries for today's world, and the application of psychedelic experience to the study of metaphysics, in essays published in Entheogens and the Future of Religion, (Council on Spiritual Practices, San Francisco, 1999); and discusses his relationship with LSD enthusiast Timothy Leary in Outside Looking In (Park Street Press, Rochester, VT, 1999). Also, a posthumous book by Albert Hofmann, Hofmann's Elixir: LSD and the New Eleusis, collecting the last essays the author wrote, was released February 24, 2010.[18]

[edit] See also

[edit] Further reading

  • Nathaniel S. Finney, Jay S. Siegel: In Memoriam – Albert Hofmann (1906–2008). Chimia 62 (2008), 444–447, doi:10.2533/chimia.2008.444
  • Roberts, Andy. Albion Dreaming: A Popular History of LSD in Britain (2008), Marshall Cavendish, U.K, 978-1905736270/1905736274

[edit] References

  1. ^ "Albert Hofmann". Multidisciplinary Association for Psychedelic Studies. Archived from the original on 30 April 2008. Retrieved 2008-04-29.
  2. ^ a b "Obituary: Albert Hofmann, LSD inventor". London: Daily Telegraph. 2008-04-29. Archived from the original on 1 May 2008.,-LSD-inventor,-dies.html. Retrieved 2008-04-29.
  3. ^ Hofmann, A. "Psilocybin und Psilocin, zwei psychotrope Wirkstoffe aus mexikanischen Rauschpilzen." Helvetica Chemica Acta 42: 1557-1572 (1959).
  4. ^ "Top 100 living geniuses". The Daily Telegraph (London). 2007-10-30.
  5. ^ a b "Freedom of speech - use it or lose it". Retrieved 2009-11-16.
  6. ^ Dr. Albert Hofmann; translated from the original German (LSD Ganz Persönlich) by J. Ott. MAPS-Volume 6 Number 69 Summer 1969
  7. ^ "Europe | LSD inventor Albert Hofmann dies". BBC News. 2008-04-30. Retrieved 2010-03-02.
  8. ^ Hofmann 1980, p. 15
  9. ^ "LSD: The Geek's Wonder Drug?". 2006-01-16. Retrieved 2008-04-29.
  10. ^ Bleidt, Barry; Michael Montagne (1996). Clinical Research in Pharmaceutical Development. Informa Health Care. pp. 36, 42–43. ISBN 0-8247-9745-0.
  11. ^ Smith, Craig S. (2006-01-07). "New York Times article". The New York Times.
  12. ^ "The comeback of LSD -".
  13. ^ Weldon, Carolyne (17 August 2012). "Meet the Lab Coat-Clad Granddaddies of LSD". blog. National Film Board of Canada. Retrieved 17 August 2012.
  14. ^ "World Psychedelic Forum".
  15. ^ Smith, Craig S. (2008-04-30). "Albert Hofmann, the Father of LSD, Dies at 102". The New York Times. Archived from the original on 1 May 2008. Retrieved 2008-04-30.
  16. ^ "LSD inventor Albert Hofmann dies aged 102". Archived from the original on 2 May 2008. Retrieved 2008-04-30.
  17. ^ "Albert Hofmann, Obituary,". The Economist. 2008-05-08. Retrieved 2008-05-08.
  18. ^ " Hofmann's Elixir: LSD and the New Eleusis". Retrieved 2009-08-14.

[edit] External links