Ankylosing spondylitis is a long-term disease that involves inflammation of the joints between the spinal bones, and the joints between the spine and pelvis. A.D.A.M.

Causes, incidence, and risk factors

The cause of ankylosing spondylitis is unknown, but genes seem to play a role.

The disease most often begins between ages 20 and 40, but it may begin before age 10. It affects more males than females.

Symptoms

The disease starts with low back pain that comes and goes.

• Pain and stiffness are worse at night, in the morning, or when you are not active. They may wake you from sleep.
• The pain typically gets better with activity or exercise.
• Back pain may begin in the sacroiliac joints (between the pelvis and spine). Over time, it may involve all or part of the spine.

You may lose motion or movement in the lower spine. You may not be able to fully expand your chest because the joints between the ribs are involved.

Fatigue is also a common symptom.

Other, less common symptoms include:

• Eye swelling or uveitis
• Heel pain
• Hip pain and stiffness
• Joint pain and joint swelling in the shoulders, knees, and ankles
• Loss of appetite
• Slight fever
• Weight loss

Signs and tests

Tests may include:

• CBC
• ESR
• HLA-B27 antigen
• X-rays of the spine and pelvis
• MRI of the spine

Treatment

Your doctor may prescribe nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce swelling and pain.

Different medicines are prescribed to calm swelling and the immune system:

• Corticosteroid therapy such as prednisone
• Sulfasalazine
• Methotrexate (taken once a week)
• TNF-inhibitors (etanercept, adalimumab, infliximab, golimumab)

Surgery may be done if pain or joint damage is severe.

Exercises can help improve posture and breathing. Lying flat on your back at night can help maintain a normal posture.

Expectations (prognosis)

The course of the disease is hard to predict. Symptoms may come and go at any time. Most people are able to function unless the hips are severely involved.

Rarely, people may have problems with:

• Abnormal heart rhythm
• Scarring or thickening of the lung tissue
• The aortic heart valve

Calling your health care provider

Call your health care provider if:

• You have symptoms of ankylosing spondylitis
• You have ankylosing spondylitis and develop new symptoms during treatment

References

1. Inman RD. The spoondyloarthropathies. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011: chap 273.
2. Sidiropoulos PI, Hatemi G, Song IH, et al. Evidence-based recommendations for the management of ankylosing spondylitis: systematic literature search of the 3E Initiative in Rheumatology involving a broad panel of experts and practising rheumatologists. Rheumatology (Oxford). 2008. 47(3):355-61. [PubMed: 18276738]

Review Date: 6/15/2012.

Reviewed by: Ariel D. Teitel, MD, MBA, Clinical Associate Professor of Medicine, NYU Langone Medical Center. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.