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  • Eight-base epigenomes

    Richard Meehan and colleagues highlight recent insights into the 5th, 6th, 7th and 8th DNA bases: 5mC, 5hmC, 5fC and 5caC

    Genome Biology 2013, 14:118
  • Caregivers unsure following first food reaction

    Parents of children who have an allergic food reaction do not receive sufficient information about allergy management, identifying a reaction, nor anxiety management until referred to an allergist, suggesting improvements are required in first line healthcare.

    Allergy, Asthma & Clinical Immunology 2013, 9:18
  • Regulation of cancer immunotherapeutics

    Vatsan et al. discuss the issues related to different cancer immunotherapeutics and provide recommendations for the evaluation and classification of these products during their development

    Journal for ImmunoTherapy of Cancer 2013, 1:5
  • Anti-CD137-mediated inhibition of EG7 lymphoma

    T cells use both perforin/granzyme and FasL mechanisms to achieve tumor inhibition following treatment of mice with anti-CD137 suggesting that they are promising therapeutic agents for cancer treatment

    Journal for ImmunoTherapy of Cancer 2013, 1:3
  • Image attributed to: wikipedia (cc RegBarc) folder

    Dual treatment to help smokers quit?

    In a randomized trial, participants seeking to quit smoking over 12 weeks did not benefit from adding nicotine patch to varenicline, suggesting that although further trials are required, there is no benefit in taking both treatments.

    BMC Medicine 2013, 11:140
  • Image attributed to: Figure 1_from the manuscript

    cLPP: a new method for exome target capture

    An approach to enrich for regions of interest in the DNA, using complementary long padlock probes, shows improved accuracy and target coverage and potentially lower cost than previous methods.

    Genome Medicine 2013, 5:50
  • Identifying function in the genome

    Laurence Hurst reflects on the range of genome biological factors determining whether mutations have a selective effect, and how knowing more might help us to predict which will cause disease.

    BMC Biology 2013, 11:58
  • Image attributed to: Belmar-Lopez et al. BMC Medicine

    Stem cell migration important for therapy

    Mesenchymal stem cells (MSCs), which could be used as vehicles for anti-cancer agents owing to tumor homing properties, have different migration and recruitment capacities dependent on their lineages, suggesting that clinical characterization to ensure efficacy and safety is vital.

    BMC Medicine 2013, 11:139
  • Image attributed to: Agricultural Research Service, Wikimedia Commons

    Synergistic gene regulation by peach viruses

    A transcriptomic analysis of infected peach fruits describes the first description of synergistic transcriptional regulation by a viroid and a plant virus.

    Virology Journal 2013, 10:164
  • Protein programmes snails shells to coil

    Comparing the expression of the decapentaplagic (dpp) gene in the mantle of gastopods with coiled and non-coiled shells reveals the molecular mechanism underlying the development of shell coiling. A protein gradient in the mantle causes asymmetric cell proliferation, leading to non-uniform shell growth which causes the shell to coil.

    EvoDevo 2013, 4:15
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