Chemical constituents in roots of Flemingia macrophylla

LI Bao-qiang1,2, SONG Qi-shi1(1. Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223, China; 2. Graduate School, Chinese Academy of Sciences, Beijing 100049, China)  

Objective To study the chemical constituents in the roots of Flemingia macrophylla Methods To separate and purify compounds by column chromatography and TLC, and to determine their chemical structures by their physical characters and spectral data. Results Eleven compounds were purified from the extraction in the roots of F. macrophylla, among them four are isoflavones, three are flavanones, and one is flavanol. They are genistein (Ⅰ), orobol (Ⅱ), 5, 7, 4′-trihydroxyisoflavone-7-O-β-D-glucopyranoside (Ⅲ), 5, 7, 4′-trihydroxy-8, 3′-diprenylflavanone (Ⅳ), 5, 7, 4′-trihydroxy-6-prenylisoflavone (Ⅴ), flemichin D (Ⅵ), lespedezaflavanone A(Ⅶ), ouratea-catechin (Ⅷ), 3, 4, 5-trimethoxybenzene-O-β-D-glucopyranoside (Ⅸ), stigmasterol-3-O-β-D-glucopyranoside (Ⅹ), and stigmasterol (Ⅺ). Conclusion Compounds Ⅲ—Ⅴ, and Ⅶ—Ⅺ are found from this plant for the first time. All the compounds are found from the roots of this plant for the first time. The active components, genistein and its isoflavone analogs, are main constituents in the roots of F. macrophylla

【Key Words】： Flemingia macrophylla Merr. isoflavone dihydroflavanone genistein
【Fund】： 中国科学院知识创新基地基金资助(110303JX28)
【CateGory Index】： R284.1

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