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Science. 1978 Sep 15;201(4360):1039-41.

Rebound insomnia: a new clinical syndrome.

Abstract

Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of sleep is attributed to the short duration of the action of these drugs. A hypothesis involving benzodiazepine receptors in the brain is proposed in which there is a delay or lag in replacement of endogenous benzodiazepine-like molecules after the abrupt withdrawal of exogenous drugs.

PMID:
684426
[PubMed - indexed for MEDLINE]
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