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Drugs That Prolong the QT Interval or Induce Torsades de Pointes

Table 62-4

Generic Name

Brand Name

Categorya

Albuterol b,c

Ventolin, Proventil

3

Amantadine

Symmetrel

2

Amiodarone

Pacerone, Cordarone

1

Amphetamine/dextroamphetamine

Adderall

3

Atomoxetine c

Strattera c

3

Azithromycin

Zithromax

2

Chloral hydrate

Noctec

2

Chloroquine

Arelan

1

Chlorpromazine

Thorazine

1

Clarithromycin

Biaxin

1

Clozapine

Clozaril

2

Dextroamphetamine

Dexadrine

3

Disopyramide

Norpace

1

Dobutamine b

Dobutrex b

3

Dolasetron b

Anzemetb b

2

Dopamine b

Intropin b

3

Droperidol

Inapsine

1

Ephedrine

Rumatuss

3

Epinephrine

Primatene, Bronkaid

3

Erythromycin c

Erythrocin c, EES c

1

Felbamate c

Felbatrol c

2

Flecainide

Tambocor

2

Foscarnet

Foscavir

2

Fosphenytoin c

Cerebyx c

2

Gemifloxacin

Factive

2

Granisetron b, c

Kytril b,c

2

Halofantrine

Halfan

1

Haloperidol

Haldol

1

Isoproterenol

Isupres, Medihaler-Iso

3

Isradipine

Dynacirc

2

Levalbuterol c

Xopenex c

3

Levofloxacin

Levaquin

2

Lithium

Lithobid, Eskalith

2

Metaproterenol

Alupent, Metaprel

3

Methadone

Dolophine, Methadose

1

Methylphenidate c

Ritalin c , Concerta c

3

Milodrine

ProAmantine

3

Moxifloxacin

Avelox

2

Nicardipine

Cardene

2

Norepinephrine

Levophed

3

Octreotide

Sandostatin

2

Ofloxacin

Floxin

2

Ondansetron b,c

Zofran b,c

2

Pentamidine

Pentam, NebuPent

1

Phenylephrine

Neosynephrine

3

Pimozide

Orap

1

Procainamide

Pronestyl

1

Pseudoephedrine

PediaCare, Sudafed

3

Quetiapine

Seroquel

2

Quinidine

Quinaglute, Cardioquin

1

Risperidone c

Risperdal c

2

Salmeterol

Serevent

3

Sotalol

Betapace

1

Tacrolimus

Prograf

2

Telithromycin

Ketek

2

Terbutaline

Brethine

3

Thioridazine

Mellaril

1

Tizanidine

Zanaflex

2

Venlafaxine

Effexor

2

Ziprasidone

Geodon

2

aCategory 1: Drugs that are generally accepted by authorities to have a risk of prolonging the QT interval and causing torsades de pointes.
Category 2: Drugs that may prolong the QT interval but at this time lack substantial evidence for causing torsades de pointes.
Category 3: Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome (in addition to drugs in categories 1 and 2).
bDrugs that are commonly used in the perioperative period.
cDrugs that are commonly used in children.
A continuously updated and complete list of drugs that prolong the QT may be found at www.azcert.org/medical-pros/drug-lists/drug-lists.cfm.

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