acetaminophen (OTC) - Tylenol, Tylenol Arthritis Pain, more..Tylenol Ext, Little Fevers Children's Fever/Pain Reliever, Little Fevers Infant Fever/Pain Reliever, PediaCare Single Dose Acetaminophen Fever Reducer/Pain Reliever

 
 
 

Dosing & Uses

AdultPediatric

Dosing Forms & Strengths

tablet

  • 325mg
  • 500mg

caplet

  • 325mg
  • 500mg
  • 650mg

capsule

  • 500mg

gelcap

  • 500mg

geltab

  • 500mg

caplet, extended-release

  • 650mg

tablet, chewable

  • 80mg
  • 160mg

tablet, oral-disintegrating

  • 80mg
  • 160mg

oral solution/suspension

  • 160mg/5mL

liquid oral

  • 500mg/5mL

Analgesia & Fever

immediate-release

  • 325-650 mg PO/PR q4hr PRN, or 500 mg PO q8hr PRN

extended-release

  • 2 capsules (1300 mg) PO q8hr PRN

maximum dose

  • Acetaminophen containing products: Not to exceed a cumulative dose of 4 g/day of acetaminophen
  • Tylenol Extra-Strength (ie, 500 mg/tab or cap): Not to exceed 3 g/day (6 tabs or caps)

See Also Combo

Acetaminophen Combos

Acetaminophen & NSAIDs

Renal Impairment

CrCl 10-50 mL/minute: Administer q6hr

CrCl <10 mL/minute: Administer q8hr

Other Indications & Uses

Potent analgesic and antipyretic activity with weak anti-inflammatory activity

Dosing Forms & Strengths

oral solution/suspension

  • 160mg/5mL
  • 240mg/7.5mL (PediCare Single Dose)
  • 320mg/10mL (PediCare Single Dose)

tablet, chewable

  • 80mg

tablet, oral-disintegrating

  • 80mg
  • 160mg

Pain & Fever Relief

<12 years: 10-15 mg/kg PO q6-8hr PRN; not to exceed 2.6 g/day (5 doses/24 hours) 

>12 years: 40-60 mg/kg/day PO divided q6hr PRN; not to exceed 3.75 g/day (5 doses/24 hours)

Potential toxic dose <6 years old: 200 mg/kg

Renal Impairment

CrCl <10 mL/minute: Administer q8hr

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Drug Interactions

Interaction Checker

acetaminophen and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Angioedema

            Disorientation

            Dizziness

            Pruritic maculopapular rash

            Rash

            Stevens-Johnson syndrome

            Toxic epidermal necrolysis

            Urticaria

            Gastrointestinal hemorrhage

            Laryngeal edema

            Agranulocytosis

            Leukopenia

            Neutropenia

            Pancytopenia

            Thrombocytopenia

            Thrombocytopenic purpura

            Hepatotoxicity

            Liver failure

            Nephrotoxicity

            Pneumonitis

            Anaphylactoid

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            Contraindications & Cautions

            Contraindications

            Hypersensitivity

            Hepatitis or hepatic/renal dysfunction, alcoholism

            Repeated administration in patients with anemia or cardiac, pulmonary, or renal disease

            Cautions

            Acetaminophen in many other dosage forms and products, check label carefully to avoid overdose

            Risk of hepatotoxicity is higher in alcoholics, chronic high dose, or use of more than one acetaminophen-containing product

            G6PD deficiency

            Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

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            Pregnancy & Lactation

            Pregnancy Category: B

            Crosses placenta, safe to use in all stages of pregnancy short term

            Lactation: excreted in breast milk; compatible with breastfeeding

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Acts on hypothalamus to produce antipyresis

            May work peripherally to pain impulse generation; may also inhibit prostaglandin synthesis in CNS

            Pharmacokinetics

            Peak Plasma Time: 10-60 min (PO immediate-release); 60-120 min (PO extended-release); 6 hr (PO 500 mg, conventional tablet); 8 hr (PO 650 mg, extended-release tablet)

            Peak Plasma Concentration: 2.1 mcg/mL (PO 500 mg, conventional tablet); 1.8 mcg/mL (PO 650 mg, extended-release tablet)

            Distribution: 1 L/kg

            Protein Bound: 10 to 25%

            Metabolism: Liver (microsomal enzyme systems); conjugation (glucuronic/sulfuric acid)

            Metabolites: N-acetyl-p-benzoquinoneimine, N-acetylimidoquinone, NAPQI; further metabolized via conjugation with glutathione

            Half-life elimination: 1.25-3 hr

            Excretion: urine (principally as acetaminophen glucuronide with acetaminophen sulfate/mercaptate)

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