Stop Signal Task
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Control of the body requires inhibiting complex actions, involving contracting and relaxing muscles. However, little is known of how voluntary commands to relax a muscle are cancelled. Action inhibition causes both suppression of muscle... more
Control of the body requires inhibiting complex actions, involving contracting and relaxing muscles. However, little is known of how voluntary commands to relax a muscle are cancelled. Action inhibition causes both suppression of muscle activity and the transient excitation of antagonist muscles, the latter being termed active breaking. We hypothesized that active breaking is present when stopping muscle relaxations. Stop signal experiments were used to compare the mechanisms of active breaking for muscle relaxations and contractions in male and female human participants. In experiments 1 and 2, go signals were presented that required participants to contract or relax their biceps or triceps muscle. Infrequent Stop signals occurred after fixed delays (0-500 ms), requiring that participants cancelled go commands. In experiment 3, participants increased (con-tract) or decreased (relax) an existing isometric finger abduction depending on the go signal, and cancelled these force changes whenever Stop signals occurred (dynamically adjusted delay). We found that muscle relaxations were stopped rapidly, met predictions of existing race models, and had Stop signal reaction times that correlated with those observed during the stopping of muscle contractions, suggesting shared control mechanisms. However, stopped relaxations were preceded by transient increases in electromyography (EMG), while stopped contractions were preceded by decreases in EMG, suggesting a later divergence of control. Muscle state-specific active breaking occurred simultaneously across muscles, consistent with a central origin. Our results indicate that the later stages of action inhibition involve separate excitatory and inhibitory pathways, which act automatically to cancel complex body movements. The mechanisms of how muscle relaxations are cancelled are poorly understood. We showed in three experiments involving multiple effectors that stopping muscle relaxations involves transient bursts of EMG activity, which resemble cocontraction and have onsets that correlate with Stop signal reaction time. Comparison with the stopping of matched muscle contractions showed that active breaking was muscle state specific, being positive for relaxations and negative for contractions. The two processes were also observed to co-occur in agonist-antagonist pairs, suggesting separate pathways. The rapid, automatic activation of both pathways may explain how complex actions can be stopped at any stage of their execution.
All actions, even the simplest like moving an arm to grasp a pen, are associated with energy costs. Thus all mobile organisms possess the ability to evaluate resources and select those behaviours that are most likely to lead to the... more
All actions, even the simplest like moving an arm to grasp a pen, are associated with energy costs. Thus all mobile organisms possess the ability to evaluate resources and select those behaviours that are most likely to lead to the greatest accrual of valuable items (rewards) in the near or, especially in the case of humans, distant future. The evaluation process is performed at all possible stages of the series of decisions that lead to the building of a goal-directed action or to its suppression. This is because all animals have a limited amount of energy and resources; to survive and be able to reproduce they have to minimize the costs and maximize the outcomes of their actions. These computations are at the root of behavioral flexibility.
Two executive functions play a major role in generating flexible behaviors: i) the ability to predict future outcomes of goal-directed actions; and ii) the ability to cancel them when they are unlikely to accomplish valuable results. These two processes operate continuously during the entire course of a movement: during its genesis, its planning and even its execution, so that the motor output can be modulated or suppressed at any time before its execution. In this review, functional interactions of the extended neural network subserving generation and inhibition of goal-directed movements will be outlined, leading to the intriguing hypothesis that the performance of actions and their suppression are not specified by independent sets of brain regions. Rather, it will be proposed that acting and stopping are functions emerging from specific interactions between largely overlapping brain regions, whose activity is intimately linked (directly or indirectly) to the evaluations of pros and cons of an action. Such mechanism would allow the brain to perform as a highly efficient and flexible system, as different functions could be computed exploiting the same components operating in different configurations.
Two executive functions play a major role in generating flexible behaviors: i) the ability to predict future outcomes of goal-directed actions; and ii) the ability to cancel them when they are unlikely to accomplish valuable results. These two processes operate continuously during the entire course of a movement: during its genesis, its planning and even its execution, so that the motor output can be modulated or suppressed at any time before its execution. In this review, functional interactions of the extended neural network subserving generation and inhibition of goal-directed movements will be outlined, leading to the intriguing hypothesis that the performance of actions and their suppression are not specified by independent sets of brain regions. Rather, it will be proposed that acting and stopping are functions emerging from specific interactions between largely overlapping brain regions, whose activity is intimately linked (directly or indirectly) to the evaluations of pros and cons of an action. Such mechanism would allow the brain to perform as a highly efficient and flexible system, as different functions could be computed exploiting the same components operating in different configurations.
Correlations between the grandiose narcissism and vulnerable narcissism with two self-report personality measures (i.e., BIS-11 and I 7) and two behavioral tasks (i.e., Stop-Signal Task and Delay-Discounting task) of impulsivity in 338... more
Correlations between the grandiose narcissism and vulnerable narcissism with two self-report personality measures (i.e., BIS-11 and I 7) and two behavioral tasks (i.e., Stop-Signal Task and Delay-Discounting task) of impulsivity in 338 students were examined. As one of the first studies to apply a two-dimensional approach to narcissism (i.e. grandiose narcissism and vulnerable narcissism) in different self-report and behavioral im-pulsivity measures, the present results have reported that both grandiose and vulnerable narcissism showed a significant positive correlations with the self-reported impulsivity. Moreover, the grandiose narcissism has shown significant associations with both behavioral tasks of impulsivity. Contrary, vulnerable narcissism was negatively related to the stop reaction time – people high in vulnerable narcissism scored shorter stop reaction time values and, consequently, presented less impulsive responding.
Self-injury is often motivated by the desire to reduce the intensity of negative affect. This suggests that people who self-injure may have difficulty suppressing negative emotions. We sought to determine whether self-injuring individuals... more
Self-injury is often motivated by the desire to reduce the intensity of negative affect. This suggests that people who self-injure may have difficulty suppressing negative emotions. We sought to determine whether self-injuring individuals exhibit impaired inhibitory control over behavioral expressions of negative emotions, when responding to images containing aversive emotional content. Self-injuring participants and healthy controls completed a Stop Signal Task in which they were asked to judge the valence (positive or negative) of images. Three types of images depicted emotional content (neutral/positive/negative). A fourth type depicted self-cutting. An unpredictable “stop signal” occurred on some trials, indicating that participants should inhibit their responses to images presented on those trials. Compared to controls, self-injuring participants showed poorer inhibition to images depicting negative emotional content. Additionally, they showed enhanced inhibition to self-injury images. In fact, self-injuring participants showed comparable response inhibition to cutting images and positive images, whereas controls showed worse inhibition to cutting images compared to all other types of images. Consistent with the emotion regulation hypothesis of self-injury, people who self-injure showed impaired negative emotional response inhibition. Self-injuring individuals also demonstrated superior control over responses to stimuli related to self-injury, which may have important clinical implications.
Adaptive adjustments of strategies are needed to optimize behavior in a dynamic and uncertain world. A key function in implementing flexible behavior and exerting selfcontrol is represented by the ability to stop the execution of an... more
Adaptive adjustments of strategies are needed to optimize behavior in a dynamic and
uncertain world. A key function in implementing flexible behavior and exerting selfcontrol
is represented by the ability to stop the execution of an action when it is no
longer appropriate for the environmental requests. Importantly, stimuli in our environment
are not equally relevant and some are more valuable than others. One example is
the gaze of other people, which is known to convey important social information
about their direction of attention and their emotional and mental states. Indeed, gaze
direction has a significant impact on the execution of voluntary saccades of an observer
since it is capable of inducing in the observer an automatic gaze-following behavior:
a phenomenon named social or joint attention. Nevertheless, people can exert volitional
inhibitory control on saccadic eye movements during their planning. Little is known about
the interaction between gaze direction signals and volitional inhibition of saccades. To fill
this gap, we administered a countermanding task to 15 healthy participants in which
they were asked to observe the eye region of a face with the eyes shut appearing at
central fixation. In one condition, participants were required to suppress a saccade, that
was previously instructed by a gaze shift toward one of two peripheral targets, when the
eyes were suddenly shut down (social condition, SC). In a second condition, participants
were asked to inhibit a saccade, that was previously instructed by a change in color of
one of the two same targets, when a change of color of a central picture occurred (nonsocial
condition, N-SC). We found that inhibitory control was more impaired in the SC,
suggesting that actions initiated and stopped by social cues conveyed by the eyes are
more difficult to withhold. This is probably due to the social value intrinsically linked to
these cues and the many uses we make of them
uncertain world. A key function in implementing flexible behavior and exerting selfcontrol
is represented by the ability to stop the execution of an action when it is no
longer appropriate for the environmental requests. Importantly, stimuli in our environment
are not equally relevant and some are more valuable than others. One example is
the gaze of other people, which is known to convey important social information
about their direction of attention and their emotional and mental states. Indeed, gaze
direction has a significant impact on the execution of voluntary saccades of an observer
since it is capable of inducing in the observer an automatic gaze-following behavior:
a phenomenon named social or joint attention. Nevertheless, people can exert volitional
inhibitory control on saccadic eye movements during their planning. Little is known about
the interaction between gaze direction signals and volitional inhibition of saccades. To fill
this gap, we administered a countermanding task to 15 healthy participants in which
they were asked to observe the eye region of a face with the eyes shut appearing at
central fixation. In one condition, participants were required to suppress a saccade, that
was previously instructed by a gaze shift toward one of two peripheral targets, when the
eyes were suddenly shut down (social condition, SC). In a second condition, participants
were asked to inhibit a saccade, that was previously instructed by a change in color of
one of the two same targets, when a change of color of a central picture occurred (nonsocial
condition, N-SC). We found that inhibitory control was more impaired in the SC,
suggesting that actions initiated and stopped by social cues conveyed by the eyes are
more difficult to withhold. This is probably due to the social value intrinsically linked to
these cues and the many uses we make of them
Although both the presupplementary motor area (pre-SMA) and the right inferior frontal gyrus (rIFG) have been demonstrated to be critical for response inhibition, there is still considerable disagreement over the roles they play in the... more
Although both the presupplementary motor area (pre-SMA) and the right inferior frontal gyrus (rIFG) have been demonstrated to be critical for response inhibition, there is still considerable disagreement over the roles they play in the process. In the present study, we investigated the causal relations of the pre-SMA and the rIFG in a conditional stop-signal task by applying offline theta-burst transcranial magnetic stimulation. The task introduced a continue condition, which requires the same motor response as in a go trial but captures attention as in a stop trial. We found great individual differences in the amount of slowing on continue trials. Temporary suppression of pre-SMA activity prolonged the continue RT in participants who slowed little in response to continue trials, whereas disruption of the rIFG did not lead to significant changes in performance irrespective of the degree of slowing. Our results contribute to the understanding of the role of the pre-SMA by providing causal evidence that it is involved in response slowing on continue trials during conditional stopping, and it is likely that its efficiency in updating motor planning and reinitiating an inhibited response was associated with the amount of slowing.
Cognitive functions like motor planning rely on the concerted activity of multiple neuronal assemblies underlying still elusive computational strategies. During reaching tasks, we observed stereotyped sudden transitions (STs) between low... more
Cognitive functions like motor planning rely on the concerted activity of multiple neuronal assemblies underlying still elusive computational strategies. During reaching tasks, we observed stereotyped sudden transitions (STs) between low and high multiunit activity of monkey dorsal premotor cortex (PMd) predicting forthcoming actions on a single-trial basis. Occurrence of STs was observed even when movement was delayed or successfully canceled after a stop signal, excluding a mere substrate of the motor execution.Anattractor model
accounts for upward STs and high-frequency modulations of field potentials, indicative of local synaptic reverberation. We found in vivo compelling evidence that motor plans in PMd emerge from the coactivation of such attractor modules, heterogeneous in the strength of local synaptic self-excitation. Modules with strong coupling early reacted with variable times to weak inputs, priming a chain reaction of both upward and downward STs in other modules. Such web of “flip-flops” rapidly converged to a stereotyped distributed representation of the motor program, as prescribed by the long-standing theory of associative networks.
accounts for upward STs and high-frequency modulations of field potentials, indicative of local synaptic reverberation. We found in vivo compelling evidence that motor plans in PMd emerge from the coactivation of such attractor modules, heterogeneous in the strength of local synaptic self-excitation. Modules with strong coupling early reacted with variable times to weak inputs, priming a chain reaction of both upward and downward STs in other modules. Such web of “flip-flops” rapidly converged to a stereotyped distributed representation of the motor program, as prescribed by the long-standing theory of associative networks.
Parkinson’s disease (PD) is often characterized by asymmetrical symptoms, which are more prominent on the side of the body contralateral to the most extensively affected brain hemisphere. Therefore, lateralized PD presents an opportunity... more
Parkinson’s disease (PD) is often characterized by asymmetrical symptoms, which are more prominent on the side of the body contralateral to the most extensively affected brain hemisphere.
Therefore, lateralized PD presents an opportunity to examine the effects of asymmetric subcortical dopamine deficiencies on cognitive functioning. As it has been hypothesized that inhibitory control
relies upon a right-lateralized pathway, we tested whether left-dominant PD (LPD) patients suffered from a more severe deficit in this key executive function than right-dominant PD patients (RPD). To this end, via a countermanding task, we assessed both proactive and reactive inhibition in 20 LPD and 20 RPD patients, and in 20 age-matched healthy subjects. As expected, we found that PD patients were significantly more impaired in both forms of inhibitory control than healthy subjects. However, there were no differences either in reactive or proactive inhibition between LPD and RPD patients. All in all, these data support the idea that brain regions affected by PD play a fundamental
role in subserving inhibitory function, but do not sustain the hypothesis according to which this executive function is predominantly or solely computed by the brain regions of the right hemisphere.
Therefore, lateralized PD presents an opportunity to examine the effects of asymmetric subcortical dopamine deficiencies on cognitive functioning. As it has been hypothesized that inhibitory control
relies upon a right-lateralized pathway, we tested whether left-dominant PD (LPD) patients suffered from a more severe deficit in this key executive function than right-dominant PD patients (RPD). To this end, via a countermanding task, we assessed both proactive and reactive inhibition in 20 LPD and 20 RPD patients, and in 20 age-matched healthy subjects. As expected, we found that PD patients were significantly more impaired in both forms of inhibitory control than healthy subjects. However, there were no differences either in reactive or proactive inhibition between LPD and RPD patients. All in all, these data support the idea that brain regions affected by PD play a fundamental
role in subserving inhibitory function, but do not sustain the hypothesis according to which this executive function is predominantly or solely computed by the brain regions of the right hemisphere.
Inhibitory control is thought to serve an adaptive function in controlling behavior, with individual differences predicting variation in numerous cognitive functions. However, inhibition is more properly construed as inducing both... more
Inhibitory control is thought to serve an adaptive function in controlling behavior, with individual differences predicting variation in numerous cognitive functions. However, inhibition is more properly construed as inducing both benefits and costs to performance. Benefits arise at the point when inhibition prevents expression of an unwanted or contextually inappropriate response; costs arise later, when access to the inhibited representation is
required by other processes. Here we illustrate how failure to consider both the costs and benefits of inhibition has generated confusion in the literature on individual differences
in cognitive control. Using retrieval-induced forgetting as a model case, we illustrate this by showing that changing the way that retrieval-induced forgetting is measured to allow greater expression of the benefits of inhibition together with the costs can reduce and even reverse the theoretically predicted correlation between motor and memory inhibition. Specifically, we show that when the final test in a retrieval-induced forgetting procedure employs item-specific cues (i.e., category-plus-stem cued recall and item-recognition) that better isolate the lingering costs of inhibition, better motor response inhibition (faster stop-signal reaction times) predicts greater retrieval-induced forgetting. In striking contrast, when the final test is less well controlled, allowing both the costs and benefits of inhibition to contribute, motor response inhibition has the opposite relationship with retrieval-induced forgetting. These findings underscore the importance of considering the correlated costs and benefits problem when studying individual differences in inhibitory control. More generally, they suggest that a shared inhibition mechanism may underlie
people’s ability to control memories and actions.
required by other processes. Here we illustrate how failure to consider both the costs and benefits of inhibition has generated confusion in the literature on individual differences
in cognitive control. Using retrieval-induced forgetting as a model case, we illustrate this by showing that changing the way that retrieval-induced forgetting is measured to allow greater expression of the benefits of inhibition together with the costs can reduce and even reverse the theoretically predicted correlation between motor and memory inhibition. Specifically, we show that when the final test in a retrieval-induced forgetting procedure employs item-specific cues (i.e., category-plus-stem cued recall and item-recognition) that better isolate the lingering costs of inhibition, better motor response inhibition (faster stop-signal reaction times) predicts greater retrieval-induced forgetting. In striking contrast, when the final test is less well controlled, allowing both the costs and benefits of inhibition to contribute, motor response inhibition has the opposite relationship with retrieval-induced forgetting. These findings underscore the importance of considering the correlated costs and benefits problem when studying individual differences in inhibitory control. More generally, they suggest that a shared inhibition mechanism may underlie
people’s ability to control memories and actions.
Communication between the prefrontal cortex and subcortical nuclei underpins the control and inhibition of behavior. However, the interactions in such pathways remain controversial. Using a stop-signal response inhibition task and... more
Communication between the prefrontal cortex and subcortical nuclei underpins the control and inhibition of behavior. However, the interactions in such pathways remain controversial. Using a stop-signal response inhibition task and functional imaging with analysis of effective connectivity, we show that the lateral prefrontal cortex influences the strength of communication between regions in the frontostriatal motor system. We compared 20 generative models that represented alternative interactions between the inferior frontal gyrus, presupplementary motor area (preSMA), subthalamic nucleus (STN), and primary motor cortex during response inhibition.
Bayesian model selection revealed that during successful response inhibition, the inferior frontal gyrus modulates an excitatory influence of the preSMA on the STN, thereby amplifying the downstream polysynaptic inhibition from the STN to the motor cortex. Critically, the strength of the interaction between preSMA and STN, and the degree of modulation by the inferior frontal gyrus, predicted individual
differences in participants’ stopping performance (stop-signal reaction time). We then used diffusion-weighted imaging with tractography to assess white matter structure in the pathways connecting these three regions. The mean diffusivity in tracts between preSMA and the STN, and between the inferior frontal gyrus and STN, also predicted individual differences in stopping efficiency. Finally, we found that white matter structure in the tract between preSMA and STN correlated with effective connectivity of the same pathway, providing important cross-modal validation of the effective connectivity measures. Together, the results demonstrate the network dynamics and
modulatory role of the prefrontal cortex that underpin individual differences in inhibitory control.
Bayesian model selection revealed that during successful response inhibition, the inferior frontal gyrus modulates an excitatory influence of the preSMA on the STN, thereby amplifying the downstream polysynaptic inhibition from the STN to the motor cortex. Critically, the strength of the interaction between preSMA and STN, and the degree of modulation by the inferior frontal gyrus, predicted individual
differences in participants’ stopping performance (stop-signal reaction time). We then used diffusion-weighted imaging with tractography to assess white matter structure in the pathways connecting these three regions. The mean diffusivity in tracts between preSMA and the STN, and between the inferior frontal gyrus and STN, also predicted individual differences in stopping efficiency. Finally, we found that white matter structure in the tract between preSMA and STN correlated with effective connectivity of the same pathway, providing important cross-modal validation of the effective connectivity measures. Together, the results demonstrate the network dynamics and
modulatory role of the prefrontal cortex that underpin individual differences in inhibitory control.
Reactive inhibition correlates with the severity of symptoms in paediatric patients with Obsessive-Compulsive Disorder (OCD) though not in those with Tourette syndrome (TS). Here we assessed whether structural alterations in both grey... more
Reactive inhibition correlates with the severity of symptoms in paediatric patients with Obsessive-Compulsive Disorder (OCD) though not in those with Tourette syndrome (TS). Here we assessed whether structural alterations in both grey (GM) and white matter (WM) volumes correlate with a measure of reactive inhibition, i.e. the stop-signal reaction time (SSRT), and with clinical scale scores. Nine OCD and 11 TS uncomplicated drug-naïve paediatric patients and 12 age-matched controls underwent 3T magnetic resonance imaging scanning. Between-group differences in GM and WM volumes across the whole brain were assessed. Outside the scanner, patients performed a reaching version of the stop-signal task. Both behavioural inhibitory control and neuroimaging measures were normal in TS patients. By contrast, OCD patients exhibited a significant loss in GM volume in five areas. The GM volume of the left inferior frontal gyrus was inversely correlated with the length of the SSRT, the left mid-cingulate gyrus and the right middle frontal gyrus were inversely correlated with the severity of OCD symptoms, and the left insula and the right medial orbitofrontal gyrus were inversely correlated with both. These results indicate that cortical areas showing GM loss in OCD patients are also involved in the network subserving reactive inhibition.
Typically, the inability to control urges tends to be ascribed to a lack of inhibitory control. Primary complex motor stereotypes (p-CMS), occurring in children with an otherwise typical development, represent a remarkable example of... more
Typically, the inability to control urges tends to be ascribed to a lack of inhibitory control. Primary complex motor stereotypes (p-CMS), occurring in children with an otherwise typical development, represent a remarkable example of involuntary, complex, repetitive and apparently purposeless movements. However, it has never been tested whether the core of the pathophysiology of p-CMS lies in a deficit of inhibitory control. To fill this gap, we assessed whether children with p-CMS exhibit an impairment of one or both types of inhibition, i.e. reactive inhibition (the ability of subjects to react to a stop-signal) and/or proactive inhibition (the ability of subjects to shape their response strategies according to the context in which subjects are embedded). We compared inhibitory control of 20 drug-naïve patients with p-CMS (mean age ±SD: 7.4±1.1) with that of 20 age- and gender-matched typically developing children (7.5±1.2) via a reaching version of the stop-signal task. We found that while reactive inhibition is significantly impaired, proactive control in children with p-CMS is similar to that of the control group. The deficit in reactive control might explain why patients are unable to inhibit involuntary movements when triggered by states of mind such as stress, fatigue, boredom or excitement. Nevertheless, the absence of a deficit in proactive control suggests that patients are aware of the environmental context and thus they quickly stop the stereotypic movements when their attention is diverted. All in all, our findings might explain two key features of the p-CMS phenotype.
The relationship between handedness, laterality, and inhibitory control is a valuable benchmark for testing the hypothesis of the right-hemispheric specialization of inhibition. According to this theory, and given that to stop a limb... more
The relationship between handedness, laterality, and inhibitory control is a valuable benchmark for testing the hypothesis of the right-hemispheric specialization of inhibition. According to this theory, and given that to stop a limb movement, it is sufficient to alter the activity of the contralateral hemisphere, then suppressing a left arm movement should be faster than suppressing a right-arm movement. This is because, in the latter case, inhibitory commands produced in the right hemisphere should be sent to the other hemisphere. Further, as lateralization of cognitive functions in left-handers is less pronounced than in right-handers, in the former, the inhibitory control should rely on both hemispheres. We tested these predictions on a medium-large sample of left- and right-handers (n = 52). Each participant completed two sessions of the reaching versions of the stop-signal task, one using the right arm and one using the left arm. We found that reactive and proactive inhibition do not differ according to handedness. However, we found a significant advantage of the right versus the left arm in canceling movements outright. By contrast, there were no differences in proactive inhibition. As we also found that participants performed movements faster with the right than with the left arm, we interpret our results in light of the dominant role of the left hemisphere in some aspects of motor control.
The precise localizations of the neural substrates of voluntary inhibition are still debated. It has been hypothesized that, in humans, this executive function relies upon a right-lateralized pathway comprising the inferior frontal gyrus... more
The precise localizations of the neural substrates of voluntary inhibition are still debated. It has been hypothesized that, in humans, this executive function relies upon a right-lateralized pathway comprising the inferior frontal gyrus and the presupplementarymotor area,whichwould control the neural processes for movement inhibition acting through the right subthalamic nucleus (STN). We assessed the role of the right STN, via a countermanding reaching task, in 10 Parkinson’s patients receiving high-frequency electrical stimulation of the STN of both hemispheres (deep brain stimulation, DBS) and in 13 healthy subjects. We compared the performance of Parkinson’s patients in 4 experimental conditions: DBS-ON, DBS-OFF, DBS-OFF right, and DBS-OFF left. We found that 1) inhibitory control is improved only when both DBS are active, that is, the reaction time to the stop signal is significantly shorter in the DBS-ON condition than in all the others, 2) bilateral stimulation of STN restores the inhibitory control to a near-normal level, and 3) DBS does not cause a general improvement in task-related motor function as it does not affect the length of the reaction times of arm movements, that is, in our experimental context, STN seems to play a selective role in response inhibition.
An experimental design is programmed using the presentation tool to investigate the global response inhibition process by quantifying the parameters such as inhibition efficiency, stop-signal delay (SSD) and stop-signal reaction time... more
An experimental design is programmed using the presentation tool to investigate the global response inhibition process by quantifying the parameters such as inhibition efficiency, stop-signal delay (SSD) and stop-signal reaction time (SSRT) in the stop-signal paradigm. The aim of this study is to explore the response inhibition mechanisms in the left-hand and right-hand responses by using ERP and ERSP results obtained from the EEG data of different subjects. The inhibition efficiency of the right-hand response and left-hand response appears to be independent of each other as there is no significant difference between them. From these results, the inhibition mechanisms corresponding to these two regions of the brain may be viewed as statistically independent processes. Further, we inferred that the response inhibition mechanisms for both left-hand and right-hand responses have approximately the same spectral power observation analysis and we conclude that these processes are statistically independent of each other.
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