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Epileptic structures marked in EEG, with corresponding MRI

Full description and rationale behind this database is described in a freely accesible paper published in Neuroinformatics: Zwoliński P, Roszkowski M, Zygierewicz J, Haufe S, Nolte G, Durka PJ. Open Database of Epileptic EEG with MRI and Postoperational Assessment of Foci-a Real World Verification for the EEG Inverse Solutions. Neuroinformatics. 2010 8:285-229.

In certain types of epilepsy, removal of the epileptogenic zone within the brain tissue is the only possible therapy due to drug-resistance. However it is still very difficult to delineate the exact localization of the epileptogenic zone without invasive EEG registration. We present first 23 cases of severe epilepsy cases diagnosed and operated for intractable epilepsy. Each surgery was performed with ECoG which enabled precise localisation of epileptogenic region. If there was resected tissue, its pathology was extensively examined. These cases provide also unique possibility of verification of the accuracy of the Inverse Solutions computed from the pre-operational surface EEG, owing to the availability of recordings from the same patients, aimed at foci localization, and post-operational assessment.

Records available at http://eeg.pl/epi include:

  • EEG:  The data consists in each case of 20-70 minutes of continuous inter-ictal EEG recording collected during the pre-surgical period. It contains inter-ictal discharges which are representative of symptomatology and are in spatial relation with the structural pathology. During the recording the subject was resting.  Data was recorded using the 10-20 system, with the Ag/AgCl electrodes, 10 mm diameter, impedance less than 5 kOhm stored in European Data Format  (EDF). Two EEG systems were used for recordings: DigiTrack EEG System by Elmiko (sampling frequency 250 Hz), and Medelec-Profile system by Medelec, Oxford Instruments (sampling frequency 256 Hz),  For both apparatuses, filters were set to pass frequency band 0.5-70 Hz; additionally, 50 Hz notch filter was applied. The hardware referencing was to electrode Fpz. The data contains no detailed fiducial documentation.
  • Marked epileptogenic waveforms: Scanned printouts of EEG epochs containing the epileptogenic structures explicitly marked by the epileptologist.
  • MRI: recordings containing a T1, T2 or FLAIR weighted brain scans with morphologic substrate of the epilepsy (mostly cortical dysplasias, dysplastic tumors etc.). In some cases there is also a scan with the gadolinium (GAD) contrast. The images were collected by Siemens Sonata 1.5T scanner. The data is stored in the DICOM format. The name of the scan's folder indicates its weighting. The scans have the following resolutions: 
    • T1: 512x512 pixels, pixel spacing  0.4687 mm, slice thickness 1.2 mm,
    • T2: 256x256 pixels, pixel spacing 0.9375 mm, slice thickness 2.5 mm. 
  • scans of 3 MRI sections per each patient with location of foci, verified by ECoG and post-operational results, marked by epileptologist
  • textual description of each case, containing demographic data of each patient, short anamnesis of epilepsy, essential symptomatology of epileptic fits, additional necessary diagnostic tests results, and concordance report for epilepsy surgery decision

Supported from Polish funds for science 2007-2010 grant N407 041 32/1646

 

In studies and paper using this database please cite: Zwoliński P, Roszkowski M, Zygierewicz J, Haufe S, Nolte G, Durka PJ. Open Database of Epileptic EEG with MRI and Postoperational Assessment of Foci-a Real World Verification for the EEG Inverse Solutions. Neuroinformatics. 2010 8:285-229. Freely accesible from here Lead field data used in the computation of inverse solution in this paper
 Title   Description   Duration of the recordings   Number of seizures included   Number of inter-ictal events 
CHIMIC Male, 9 y.o. , with severe form of epilepsy of temporal lobe origin 40'12" 0 4
FRAANN Female, 17 y.o., with severe form of temporal lobe epilepsy 28'24" 0 3
HRADAW Male, 12 y.o., with drug-resistant generalized seizures 23'0" 0 4
JANPAT Female, 10 y.o., with severe form of temporal lobe epilepsy 20'03' 0 4
JANPRZ Male, 5 y.o., with severe form of epilepsy since 1 y.o. 32'36" 0 4
JATKAM Female, 14 y.o., with severe temporal lobe epilepsy caused by very unique multiple pathology 20'00" 0 7
GILPAU Female, 14 y.o., with severe frontal lobe seizures 20'03" 0 5
GREOSK Male, 13 y.o., with intermittent epilepsy of temporal lobe 20'09" 0 3
JERKAT Female, 15 y.o., with severe epilepsy and moderate cognitive impairment 20'03" 0 5
KOSPAW Male, 16 y.o. , with occasional epileptic fits and mild cognitive impairment 20'03" 0 3
KOTLUK Male, 17 y.o., with refractory epilepsy of temporal origin 20'58" 0 2
KROMIC Male, 16 y.o., with severe epilepsy and mild cognitive impairment 20'06" 0 5
LADJAN Male, 10 y.o., with drug resistant epilepsy of frontal origin 22'24" 0 5
MARPAW Male, 16 y.o., with drug resistant epilepsy of temporal origin 26'12" 0 6
MATPAW Male, 15 y.o., with generalized seizures and parietal lobe tumor 20'24" 0 3
MEZLUK Male, 4 y.o., with severe epilepsy of left temporal lobe 0'59" 0 2
NASNAD Female, 1 y.o., with severe infantile spasm and focal seizures due to large FCD 22'25" 0 4
NIZMAR Male, 12 y.o., with motor seizures and frontal lobe tumor 21'27" 0 3
NOWJON Male, 15 y.o., with typical picture of temporal lobe epilepsy 20'03" 0 3
PAKDAM Male, 13 y.o., with gross, disseminated FCD of right hemisphere and contralateral hemiparesis and mild cognitive impairment 1h12'35" 0 4
SIEGRZ Male, 18 y.o., with typical MTLE 20'03" 0 4
SNOKAC Male, 3 y.o., with drug resistant epilepsy and right lobe FCD 20'03" 0 6
STAMIC Male, 15 y.o., with epilepsy due to right frontal lobe tumor 20'28" 0 5
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