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Comput Biol Med. 2012 May;42(5):631-8. doi: 10.1016/j.compbiomed.2012.03.002. Epub 2012 Mar 23.

Flow patterns and deposition fraction of particles in the range of 0.1-10μm at trachea and the first third generations under different breathing conditions.

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  • 1GARPAM Design and Engineering Co Ltd., Tehran, Iran. mahmoudi_mech@yahoo.com

Abstract

The velocity field and deposition fraction of the particles in the trachea and the first third generations of tracheobronchial tree are investigated with CFD simulation. The air flow rate of trachea is considered to be in the range of 15-60l/min in accordance to four different activity levels of male adults. A physiologically realistic dichotomic airway bifurcation geometry with structured hexahedral meshes are constructed. The simulations with different hexahedral mesh densities have shown that the grid independent results will be reached with the average dimensionless distance of the first cell to the walls of y(+)≈0.5. The deposition fraction graph for particles in the range of 0.1-10μm diameter has a minimum in the range of 0.1-1μm particle diameter and after that it increases for larger particles. The results of the simulations under different breathing pattern have shown that deposition fraction significantly increases at higher Reynolds and Stokes numbers.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22445097
[PubMed - indexed for MEDLINE]
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