, Volume 23, Issue 2, pp 257-263
First online:
Chemopreventive effect of Padina boergesenii extracts on ferric nitrilotriacetate (Fe-NTA)-induced oxidative damage in Wistar rats
- Rajamani KarthikeyanAffiliated withCAS in Marine Biology, Annamalai University Email author
- , T. ManivasagamAffiliated withDepartment of Biochemistry & Biotechnology, Annamalai University
- , P. AnantharamanAffiliated withCAS in Marine Biology, Annamalai University
- , T. BalasubramanianAffiliated withCAS in Marine Biology, Annamalai University
- , S. T. SomasundaramAffiliated withCAS in Marine Biology, Annamalai UniversityCAS in Marine Biology, Annamalai University Email author
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The present study was designed to investigate the prophylactic effect of extracts of the brown alga Padina boergesenii against potent nephrotoxic agent ferric nitrilotriacetate (Fe-NTA), in blood circulation of rats. Administration of Fe-NTA for seven consecutive days significantly enhanced lipid peroxidation accompanied with reduction in glutathione content. Together with this, the level of antioxidant enzymes, glutathione peroxidase, superoxide dismutase, and catalase was significantly (P < 0.05) diminished. Pretreatment of rats with P. boergesenii (150 mg kg−1 body weight) reversed Fe-NTA-induced oxidative damage in lipid peroxidation and glutathione content significantly (P < 0.05). Further, the activity of antioxidant enzymes was also restored significantly. In order to assess the role of polyphenolic components in the relevant activity, phenolic contents of the extract was found to be 1.78 ± 0.02% in the methanol extract and 1.30 ± 0.30% in the diethyl ether extract. Hence, the present results confirm that the brown alga P. boergesenii preclude its role in Fe-NTA-induced oxidative damage and hyperproliferative response in circulation.
Keywords
Ferric nitrilotriacetate Oxidative stress Total phenolics Antioxidant activity- Title
- Chemopreventive effect of Padina boergesenii extracts on ferric nitrilotriacetate (Fe-NTA)-induced oxidative damage in Wistar rats
- Journal
-
Journal of Applied Phycology
Volume 23, Issue 2 , pp 257-263
- Cover Date
- 2011-04
- DOI
- 10.1007/s10811-010-9564-0
- Print ISSN
- 0921-8971
- Online ISSN
- 1573-5176
- Publisher
- Springer Netherlands
- Additional Links
- Topics
- Keywords
-
- Ferric nitrilotriacetate
- Oxidative stress
- Total phenolics
- Antioxidant activity
- Industry Sectors
- Authors
-
- Rajamani Karthikeyan (1)
- T. Manivasagam (2)
- P. Anantharaman (1)
- T. Balasubramanian (1)
- S. T. Somasundaram (1) (3)
- Author Affiliations
-
- 1. CAS in Marine Biology, Annamalai University, Parangipettai, 608 502, India
- 2. Department of Biochemistry & Biotechnology, Annamalai University, Annamalai Nagar, India
- 3. CAS in Marine Biology, Annamalai University, Parangipettai, 608 502, Tamil Nadu, India