"Our reports suggest that around 20 suspected militants were killed when a missile hit a house in Mohammad Khel village in North Waziristan. Most were foreigners," a senior Pakistani security official said, according to a foreign news agency.
A local intelligence official said that 21 were killed including 16 foreigners, adding that most of those were Arabs. The house belonged to two Afghan refugees settled in the area, the official said.
Officials had no details about the identity of those killed.
There was no immediate confirmation from the Pakistani military or from the US-led coalition in Afghanistan.
The Pakistani military separately denied local reports that US helicopters and fighter jets from Afghanistan killed several people, including two woman and a child, in another part of North Waziristan earlier on Friday.
Local officials said US air power hit a village lying just inside Pakistan's territory after US troops came under fire in Afghanistan's Khost province. But the army said the incident happened in Afghanistan itself. --IRNA