Studien in Durchführung und durchgeführte Studien:
EXTREME: Studie zur Behandlung von fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen in der Palliativsituation (Kombination von Platin, 5-FU und Cetuximab)
SYM004-02: An open-label, single arm, multicenter, proof of concept trial (phase IIa) of the anti-EGFR antibody mixture Sym004 in patients with squamous cell carcinoma of the head and neck failing anti EGFR-based therapy.
ICRAT: Induction Chemo-Radio-Antibody-Treatment; Randomisierte Phase-II Studie zu zwei Varianten einer TPF-Induktions-Chemotherapie gefolgt von einer Radio-Antikörpertherapie mit Cetuximab (TPF-CET-HART) vs. einer simultanen Radiochemotherapie mit HART (Hyperfraktioniert Akzelerierte RadioTherapie) und Cis-platinum, 5-FU (PF-HART) bei Patienten mit lokal fortgeschrittenen irresektablen Kopf-Hals- Tumoren.
LUX Head & Neck 1: A randomised, open-label, phase III trial to evaluate the efficacy and safety of oral afatinib (BIBW 2992) versus intravenous methotrexate in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who have progressed after platinum-based therapy. Laufende Studien:
RESGEX: Randomize, controlled, open label, multicenter, phase II study to evaluate the efficacy and safety of CetuGEX plus chemotherapy in comparison to cetuximab plus chemotherapy for the treatment of patients with stage III/IV recurrent and /or metastatic squamous cell carcinoma of the head and neck.
CA209-141: An Open Label, Randomized Phase 3 Clinical Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Platinum-refractory Squamous Cell Carcinoma of the Head and Neck (SCCHN)
CUP-Studie: Die Prävalenz von HPV-Infektionen in zervikalen Metastasen bei Patienten mit einem CUP-Syndrom in der Bundesrepublik Deutschland.
Studie zur Ermittlung der Lebensqualität nach Tumortherapie:
HCHS: Prävalenz von oropharyngealen HPV-Infektionen innerhalb der Hamburg City Health Study (HCHS)
Geplante Studien:
TOS vs pRCT: Comparative Effectiveness Trial of Transoral Head And Neck Surgery followed by adjuvant Radio(chemo)therapy versus primary Radiochemotherapy for Oropharyngeal Cancer
TPExtreme (GORTEC 2014-01): Randomized, controlled trial of Platinum-Cetuximab combined either with Docetaxel (TPEx) or with 5FU (Extreme) in patients with recurrent/metastatic squamous cell cancer of the head and neck
D5660C00004: A Phase 1b/2, Open-Label, Multicentre Study Assessing the Safety,Tolerability, Pharmacokinetics, and Preliminary Anti-tumour Activity of MEDI4736 in Combination With AZD9150 or AZD5069 in Patients With Advanced Solid Malignancies and Subsequently Comparing AZD9150 and AZD5069 Both as Monotherapy and in Combination With MEDI4736 as Second Line Treatment in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck
DWI-MRT: Bedeutung der Perfusions- und Diffusions-gewichteten Magnet-Resonanz-Tomographie (DW-MRT) für Therapieplanung und -monitoring der Radiochemotherapie von Kopf-Hals-Tumoren.
HEALOS-Studie: multizentrische, radnomisierte, plazebokontrollierte Phase-3-Studie zur Behandlung von Patienten mit idiopatischem, akutem Hörsturz