Prostaglandin D2 receptor 2 (DP2) is a human protein encoded by the PTGDR2 gene.[1] DP2 has also been designated as CD294 (cluster of differentiation 294).
G protein-coupled receptors (GPCRs), such as DP2, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][1]
DP2 has recently been found when activated by elevated level of prostaglandin D2 (PGD2), it could inhibit hair growth. This suggests the DP2 pathway as a potential target for bald treatment.[2] A particularly promising compound for blocking the DP2 pathway is a compound known as TM30089, which exhibits a "functional insurmountability" of PGD2 expression.[3]
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Sandig H, Andrew D, Barnes AA, Sabroe I, Pease J (Jan 2006). "9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2". FEBS Letters580 (2): 373–9. doi:10.1016/j.febslet.2005.11.052. PMID16378605.
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